product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Rb (IF8) Antibody
catalog :
sc-102
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
IF8
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, other, western blot knockout validation
citations: 66
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 5f
  • western blot knockout validation; mouse; loading ...; fig 3d
Choiniere J, Wu J, Wang L. Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins. Mol Pharmacol. 2017;91:189-196 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 1d
Aboouf M, Armbruster J, Thiersch M, Guscetti F, Kristiansen G, Schraml P, et al. Pro-Apoptotic and Anti-Invasive Properties Underscore the Tumor-Suppressing Impact of Myoglobin on a Subset of Human Breast Cancer Cells. Int J Mol Sci. 2022;23: pubmed publisher
  • western blot; human; loading ...; fig 5a
Kaminska K, Akrap N, Staaf J, Alves C, Ehinger A, Ebbesson A, et al. Distinct mechanisms of resistance to fulvestrant treatment dictate level of ER independence and selective response to CDK inhibitors in metastatic breast cancer. Breast Cancer Res. 2021;23:26 pubmed publisher
  • western blot; human; loading ...; fig s1d
Ruscetti M, Leibold J, Bott M, Fennell M, Kulick A, Salgado N, et al. NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science. 2018;362:1416-1422 pubmed publisher
  • western blot; human; loading ...; fig 5c
He D, Ren B, Liu S, Tan L, Cieply K, Tseng G, et al. Oncogenic activity of amplified miniature chromosome maintenance 8 in human malignancies. Oncogene. 2017;36:3629-3639 pubmed publisher
  • western blot; human; loading ...; fig 6b
Cunningham C, Li S, Vizeacoumar F, Bhanumathy K, Lee J, Parameswaran S, et al. Therapeutic relevance of the protein phosphatase 2A in cancer. Oncotarget. 2016;7:61544-61561 pubmed publisher
  • western blot; human; 1:500; fig 2
Ercilla A, Llopis A, Feu S, Aranda S, Ernfors P, Freire R, et al. New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress. Nucleic Acids Res. 2016;44:4745-62 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • western blot; human; fig 2d
Vijayalingam S, Subramanian T, Zhao L, Chinnadurai G. The Cellular Protein Complex Associated with a Transforming Region of E1A Contains c-MYC. J Virol. 2016;90:1070-9 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig st1
Hwang J, Sung W, Tu H, Hsieh K, Yeh C, Chen C, et al. The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma. PLoS ONE. 2015;10:e0139435 pubmed publisher
  • immunohistochemistry; mouse
Costales M, Lopez F, García Inclán C, Fernandez S, Marcos C, Llorente J, et al. Establishment and characterization of an orthotopic sinonasal squamous cell carcinoma mouse model. Head Neck. 2015;37:1769-75 pubmed publisher
  • western blot; human; 1:1000
Tanaka T, Iino M. Knockdown of Sec8 promotes cell-cycle arrest at G1/S phase by inducing p21 via control of FOXO proteins. FEBS J. 2014;281:1068-84 pubmed publisher
  • western blot; human
Garcia Jove Navarro M, Basset C, Arcondeguy T, Touriol C, Perez G, Prats H, et al. Api5 contributes to E2F1 control of the G1/S cell cycle phase transition. PLoS ONE. 2013;8:e71443 pubmed publisher
  • western blot; human
Jarboui M, Bidoia C, Woods E, Roe B, Wynne K, Elia G, et al. Nucleolar protein trafficking in response to HIV-1 Tat: rewiring the nucleolus. PLoS ONE. 2012;7:e48702 pubmed publisher
  • western blot; human
Pappa A, Brown D, Koutalos Y, DeGregori J, White C, Vasiliou V. Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. J Biol Chem. 2005;280:27998-8006 pubmed
Waku T, Nakamura N, Koji M, Watanabe H, Katoh H, Tatsumi C, et al. NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein. Mol Cell Biol. 2020;40: pubmed publisher
Ko T, Sharma R, Li S. Genome-wide screening identifies novel genes implicated in cellular sensitivity to BRAFV600E expression. Oncogene. 2019;: pubmed publisher
McLaughlin R, He J, van der Noord V, Redel J, Foekens J, Martens J, et al. A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy. Breast Cancer Res. 2019;21:77 pubmed publisher
Chen M, Wan L, Zhang J, Zhang J, Méndez L, Clohessy J, et al. Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism. Nat Commun. 2018;9:159 pubmed publisher
Wang Y, Liui H, Fu R, Wang Z, Ren H, Dai Z, et al. HDAC Inhibitor Oxamflatin Induces Morphological Changes and has Strong Cytostatic Effects in Ovarian Cancer Cell Lines. Curr Mol Med. 2016;16:232-42 pubmed
Wu J, Simonette R, Nguyen H, Doan H, Rady P, Tyring S. Emerging differential roles of the pRb tumor suppressor in trichodysplasia spinulosa-associated polyomavirus and Merkel cell polyomavirus pathogeneses. J Clin Virol. 2016;76:40-3 pubmed publisher
Caligiuri I, Toffoli G, Giordano A, Rizzolio F. pRb controls estrogen receptor alpha protein stability and activity. Oncotarget. 2013;4:875-83 pubmed
Chen Y, Chu H, Ze Shiang Lin -, Shiah W, Chou C, Klimstra D, et al. p16 Stimulates CDC42-dependent migration of hepatocellular carcinoma cells. PLoS ONE. 2013;8:e69389 pubmed publisher
Szalmás A, Gyöngyösi E, Ferenczi A, László B, Karosi T, Csomor P, et al. Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein. Virol J. 2013;10:79 pubmed publisher
Cho H, Hayami S, Toyokawa G, Maejima K, Yamane Y, Suzuki T, et al. RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation. Neoplasia. 2012;14:476-86 pubmed
Nande R, Di Benedetto A, Aimola P, de Carlo F, Carper M, Claudio C, et al. Targeting a newly established spontaneous feline fibrosarcoma cell line by gene transfer. PLoS ONE. 2012;7:e37743 pubmed publisher
Ginestier C, Monville F, Wicinski J, Cabaud O, Cervera N, Josselin E, et al. Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target. Stem Cells. 2012;30:1327-37 pubmed publisher
Rizzolio F, Caligiuri I, Lucchetti C, Fratamico R, Tomei V, Gallo G, et al. Dissecting Pin1 and phospho-pRb regulation. J Cell Physiol. 2013;228:73-7 pubmed publisher
Taura M, Suico M, Koyama K, Komatsu K, Miyakita R, Matsumoto C, et al. Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells. Mol Cell Biol. 2012;32:1581-90 pubmed publisher
Kothari V, Mulherkar R. Inhibition of cyclin D1 by shRNA is associated with enhanced sensitivity to conventional therapies for head and neck squamous cell carcinoma. Anticancer Res. 2012;32:121-8 pubmed
Vranic S, Gatalica Z, Wang Z. Update on the molecular profile of the MDA-MB-453 cell line as a model for apocrine breast carcinoma studies. Oncol Lett. 2011;2:1131-1137 pubmed
Zheng Z, Li L, Liu X, Wang D, Tu B, Wang L, et al. 5-Aza-2'-deoxycytidine reactivates gene expression via degradation of pRb pocket proteins. FASEB J. 2012;26:449-59 pubmed publisher
Camboni M, Hammond S, Martin L, Martin P. Induction of a regenerative microenvironment in skeletal muscle is sufficient to induce embryonal rhabdomyosarcoma in p53-deficient mice. J Pathol. 2012;226:40-9 pubmed publisher
Musumeci G, Cardile V, Fenga C, Caggia S, Loreto C. Mineral fibre toxicity: expression of retinoblastoma (Rb) and phospho-retinoblastoma (pRb) protein in alveolar epithelial and mesothelial cell lines exposed to fluoro-edenite fibres. Cell Biol Toxicol. 2011;27:217-25 pubmed publisher
Heijink D, Fehrmann R, de Vries E, Koornstra J, Oosterhuis D, van der Zee A, et al. A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer. Oncogene. 2011;30:2026-36 pubmed publisher
Cimica V, Smith M, Zhang Z, Mathur D, Mani S, Kalpana G. Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen. BMC Cancer. 2010;10:634 pubmed publisher
Nakaya R, Takaya J, Onuki T, Moritani M, Nozaki N, Ishimi Y. Identification of proteins that may directly interact with human RPA. J Biochem. 2010;148:539-47 pubmed publisher
Sherrill J, Sparks M, Dennis J, Mansour M, Kemppainen B, Bartol F, et al. Developmental exposures of male rats to soy isoflavones impact Leydig cell differentiation. Biol Reprod. 2010;83:488-501 pubmed publisher
Fernandez K, Serinagaoglu Y, Hammond S, Martin L, Martin P. Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts. Am J Pathol. 2010;176:416-34 pubmed publisher
Naryzhny S. Blue Dry Western: simple, economic, informative, and fast way of immunodetection. Anal Biochem. 2009;392:90-5 pubmed publisher
Batsi C, Markopoulou S, Kontargiris E, Charalambous C, Thomas C, Christoforidis S, et al. Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation. Biochem Pharmacol. 2009;78:33-44 pubmed publisher
Padmakumar V, Aleem E, Berthet C, Hilton M, Kaldis P. Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53. Mol Cell Biol. 2009;29:2582-93 pubmed publisher
Stengel K, Thangavel C, Solomon D, Angus S, Zheng Y, Knudsen E. Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters. J Biol Chem. 2009;284:19265-71 pubmed publisher
Cheung A, Lung H, Hung S, Law E, Cheng Y, Yau W, et al. Functional analysis of a cell cycle-associated, tumor-suppressive gene, protein tyrosine phosphatase receptor type G, in nasopharyngeal carcinoma. Cancer Res. 2008;68:8137-45 pubmed publisher
Rieber M, Rieber M. Sensitization to radiation-induced DNA damage accelerates loss of bcl-2 and increases apoptosis and autophagy. Cancer Biol Ther. 2008;7:1561-6 pubmed
Hu H, Zielinska Kwiatkowska A, Munro K, Wilcox J, Wu D, Yang L, et al. EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cells. J Orthop Res. 2008;26:886-93 pubmed publisher
Jackman K, Frye C, Hunger S. Flavopiridol displays preclinical activity in acute lymphoblastic leukemia. Pediatr Blood Cancer. 2008;50:772-8 pubmed
Kohyama S, Morimoto Y, Nakai K, Kaji T, Tokumaru A, Nawashiro H, et al. Effectiveness of narrow-band ultraviolet-B phototherapy for prevention of intimal hyperplasia in a rat carotid balloon injury model. Lasers Surg Med. 2007;39:659-66 pubmed
Holaska J, Wilson K. An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. Biochemistry. 2007;46:8897-908 pubmed
Marusyk A, Wheeler L, Mathews C, DeGregori J. p53 mediates senescence-like arrest induced by chronic replicational stress. Mol Cell Biol. 2007;27:5336-51 pubmed
Yosifov D, Dineva I, Zaharieva M, Konstantinov S, Berger M. The expression level of the tumor suppressor retinoblastoma protein (Rb) influences the antileukemic efficacy of erucylphospho-N,N,N-trimethylpropylammonium (ErPC3). Cancer Biol Ther. 2007;6:930-5 pubmed
Morelli F, Peluso G, Petillo O, Giannattasio A, Filosa S, Motta C, et al. The immunomodulatory protein SV-IV protects serum-deprived cells against apoptosis but not against G0/G1 arrest: possible implications for the survival of implanting embryo. J Cell Physiol. 2007;212:610-25 pubmed
Chen Z, Fu L, Herrero R, Schiffman M, Burk R. Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45. Int J Cancer. 2007;121:193-8 pubmed
Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, Nakayama K, et al. Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol. 2006;8:1291-7 pubmed
Pasder O, Shpungin S, Salem Y, Makovsky A, Vilchick S, Michaeli S, et al. Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells. Oncogene. 2006;25:4194-206 pubmed
Mao X, Orchard G, Vonderheid E, Nowell P, Bagot M, Bensussan A, et al. Heterogeneous abnormalities of CCND1 and RB1 in primary cutaneous T-Cell lymphomas suggesting impaired cell cycle control in disease pathogenesis. J Invest Dermatol. 2006;126:1388-95 pubmed
Liu C, Wang R, Berndt N. Protein phosphatase 1alpha activity prevents oncogenic transformation. Mol Carcinog. 2006;45:648-56 pubmed
Bahri R, Hirsch F, Josse A, Rouas Freiss N, Bidere N, Vasquez A, et al. Soluble HLA-G inhibits cell cycle progression in human alloreactive T lymphocytes. J Immunol. 2006;176:1331-9 pubmed
Collins A, Nakahara T, Do A, Lambert P. Interactions with pocket proteins contribute to the role of human papillomavirus type 16 E7 in the papillomavirus life cycle. J Virol. 2005;79:14769-80 pubmed
Kato H, Inoue T, Asanoma K, Nishimura C, Matsuda T, Wake N. Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1. Int J Cancer. 2006;118:1144-53 pubmed
Yao C, Lai G, Chan C, Cheng A, Yang Y, Chuang S. Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone. Int J Cancer. 2006;118:773-9 pubmed
Varela I, Cadinanos J, Pendas A, Gutierrez Fernandez A, Folgueras A, Sanchez L, et al. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature. 2005;437:564-8 pubmed
Esposito V, Baldi A, De Luca A, Tonini G, Vincenzi B, Santini D, et al. Cell cycle related proteins as prognostic parameters in radically resected non-small cell lung cancer. J Clin Pathol. 2005;58:734-9 pubmed
Gery S, Tanosaki S, Hofmann W, Koppel A, Koeffler H. C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation. Oncogene. 2005;24:1589-97 pubmed
Loercher A, Tank E, Delston R, Harbour J. MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A. J Cell Biol. 2005;168:35-40 pubmed
Halaban R, Cheng E, Smicun Y, Germino J. Deregulated E2F transcriptional activity in autonomously growing melanoma cells. J Exp Med. 2000;191:1005-16 pubmed
product information
Catalog Number :
sc-102
Product Name :
Rb (IF8) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
IF8
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Rb
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), FCM
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA