product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
YAP (63.7) Antibody
catalog :
sc-101199
quantity :
100 µg/ml
price :
333 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
63.7
reactivity :
human, mouse, dogs, zebrafish
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, other, western blot knockout validation
citations: 160
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 1a
LeBlanc L, Lee B, Yu A, Kim M, Kambhampati A, Dupont S, et al. Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation. elife. 2018;7: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 5e, 5f
  • western blot; human; 1:1000; loading ...; fig 5a
Lu Y, Mu Y, Chen J, Guan X, Guo L, Wu C. CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1. Theranostics. 2022;12:5051-5068 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 5j
  • western blot; human; loading ...; fig s4c, s4d
Li X, Zhuo S, Zhuang T, Cho Y, Wu G, Liu Y, et al. YAP inhibits ERα and ER+ breast cancer growth by disrupting a TEAD-ERα signaling axis. Nat Commun. 2022;13:3075 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 5a
Kaplan M, Flucher B. Counteractive and cooperative actions of muscle β-catenin and CaV1.1 during early neuromuscular synapse formation. iScience. 2022;25:104025 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s9e, s11
Esposito D, Pant I, Shen Y, Qiao R, Yang X, Bai Y, et al. ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation. Nat Commun. 2022;13:703 pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 6a
Haroon M, Boers H, Bakker A, Bloks N, Hoogaars W, Giordani L, et al. Reduced growth rate of aged muscle stem cells is associated with impaired mechanosensitivity. Aging (Albany NY). 2022;14:28-53 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 6, s6
  • western blot; human; loading ...; fig 5b
Mygland L, Brinch S, Strand M, Olsen P, Aizenshtadt A, Lund K, et al. Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. iScience. 2021;24:102807 pubmed publisher
  • immunocytochemistry; human; fig 4f
Pocaterra A, Scattolin G, Romani P, Ament C, Ribback S, Chen X, et al. Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development. Commun Biol. 2021;4:763 pubmed publisher
  • immunocytochemistry; mouse; 1:50; loading ...
Jungwirth U, van Weverwijk A, Evans R, Jenkins L, Vicente D, Alexander J, et al. Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis. Nat Commun. 2021;12:3516 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 2b
Yuan T, Zheng R, Zhou X, Jin P, Huang Z, Zi X, et al. Abnormal Expression of YAP Is Associated With Proliferation, Differentiation, Neutrophil Infiltration, and Adverse Outcome in Patients With Nasal Inverted Papilloma. Front Cell Dev Biol. 2021;9:625251 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig 4b
Della Chiara G, Gervasoni F, Fakiola M, Godano C, D Oria C, Azzolin L, et al. Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ. Nat Commun. 2021;12:2340 pubmed publisher
  • immunocytochemistry; mouse; 1:250; loading ...; fig 5a
  • western blot; mouse; 1:2000; loading ...; fig 5h
Silver J, G xfc nay K, CUTLER A, Vogler T, Brown T, Pawlikowski B, et al. Injury-mediated stiffening persistently activates muscle stem cells through YAP and TAZ mechanotransduction. Sci Adv. 2021;7: pubmed publisher
  • immunocytochemistry; mouse; 1:300; loading ...; fig 3d
Jiang C, Javed A, Kaiser L, Nava M, Xu R, Brandt D, et al. Mechanochemical control of epidermal stem cell divisions by B-plexins. Nat Commun. 2021;12:1308 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 5f
  • immunocytochemistry; mouse; 1:100; loading ...; fig 2f
  • immunocytochemistry; human; 1:100; loading ...; fig 1i
  • western blot; human; 1:1000; loading ...; fig 2b
Zhou R, Wu Q, Wang M, Irani S, Li X, Zhang Q, et al. The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration. PLoS Biol. 2021;19:e3001122 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 8b
  • western blot; mouse; 1:200; loading ...; fig 7e
Delgado E, Erickson H, Tao J, Monga S, Duncan A, Anakk S. Scaffolding Protein IQGAP1 is Dispensable But Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling. Mol Cell Biol. 2021;: pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Han Z, Wang X, Xu Z, Cao Y, Gong R, Yu Y, et al. ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1. Theranostics. 2021;11:3000-3016 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 6c
Seo G, Han H, Vargas R, Yang B, Li X, Wang W. MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation. Cell Rep. 2020;32:107860 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig s6a
Waaler J, Mygland L, Tveita A, Strand M, Solberg N, Olsen P, et al. Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Commun Biol. 2020;3:196 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1b
  • western blot; human; loading ...; fig 1a
Bae S, Ni L, Luo X. STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism. elife. 2020;9: pubmed publisher
  • immunoprecipitation; human; loading ...; fig 2c
  • immunocytochemistry; human; loading ...; fig 1e
  • western blot; human; 1:500; loading ...; fig 1f
An L, Nie P, Chen M, Tang Y, Zhang H, Guan J, et al. MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway. J Exp Med. 2020;217: pubmed publisher
  • immunocytochemistry; human; 1:200; fig e5r
Diaz Cuadros M, Wagner D, Budjan C, Hubaud A, Tarazona O, Donelly S, et al. In vitro characterization of the human segmentation clock. Nature. 2020;580:113-118 pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig 2c
Quilichini E, Fabre M, Dirami T, Stedman A, De Vas M, Ozguc O, et al. Pancreatic ductal deletion of Hnf1b disrupts exocrine homeostasis, leads to pancreatitis and facilitates tumorigenesis. Cell Mol Gastroenterol Hepatol. 2019;: pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 1b
  • western blot; human; 1:500; loading ...; fig 2e
Lee J, Chang J, Dominguez A, Lee H, Nam S, Chang J, et al. YAP-independent mechanotransduction drives breast cancer progression. Nat Commun. 2019;10:1848 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 3a
  • immunohistochemistry; zebrafish ; 1:200; loading ...; fig s7b
Moro A, Driscoll T, Boraas L, Armero W, Kasper D, Baeyens N, et al. MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis. Nat Cell Biol. 2019;21:348-358 pubmed publisher
  • western blot; human; loading ...; fig 1f
Rausch V, Bostrom J, Park J, Bravo I, Feng Y, Hay D, et al. The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae. Curr Biol. 2019;29:242-255.e6 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 3d
Pan W, Moroishi T, Koo J, Guan K. Cell type-dependent function of LATS1/2 in cancer cell growth. Oncogene. 2019;38:2595-2610 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig s4i
Gut G, Herrmann M, Pelkmans L. Multiplexed protein maps link subcellular organization to cellular states. Science. 2018;361: pubmed publisher
  • western blot; human; fig 1e
Liu H, Dai X, Cao X, Yan H, Ji X, Zhang H, et al. PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin β2 expression. EMBO Rep. 2018;19: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1a
Ahmed A, Habeebu S, Sherman A, Ye S, Wood N, Chastain K, et al. Potential Value of YAP Staining in Rhabdomyosarcoma. J Histochem Cytochem. 2018;66:577-584 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 5b
Ibar C, Kirichenko E, Keepers B, Enners E, Fleisch K, Irvine K. Tension-dependent regulation of mammalian Hippo signaling through LIMD1. J Cell Sci. 2018;131: pubmed publisher
  • western blot; human; 1:500; loading ...; fig 4b
Liu L, Wu B, Cai H, Li D, Ma Y, Zhu X, et al. Tiam1 promotes thyroid carcinoma metastasis by modulating EMT via Wnt/?-catenin signaling. Exp Cell Res. 2018;362:532-540 pubmed publisher
  • western blot; human; loading ...; fig 9e
Kim J, Kim Y, Kim J, Park D, Bae H, Lee D, et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017;127:3441-3461 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig s2c
Nardone G, Oliver De La Cruz J, Vrbsky J, Martini C, Pribyl J, Skladal P, et al. YAP regulates cell mechanics by controlling focal adhesion assembly. Nat Commun. 2017;8:15321 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 3e
Zhu G, Chen Y, Zhang X, Wu Q, Zhao Y, Chen Y, et al. 12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT. Sci Rep. 2017;7:44940 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 3b
Ragni C, Diguet N, Le Garrec J, Novotova M, Resende T, Pop S, et al. Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun. 2017;8:14582 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig S61B
Pósfai E, Petropoulos S, de Barros F, Schell J, Jurisica I, Sandberg R, et al. Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo. elife. 2017;6: pubmed publisher
  • immunohistochemistry; dogs; loading ...; fig s3a
Valon L, Marín Llauradó A, Wyatt T, Charras G, Trepat X. Optogenetic control of cellular forces and mechanotransduction. Nat Commun. 2017;8:14396 pubmed publisher
  • immunocytochemistry; human; 1:300; loading ...; fig 2d
Heidary Arash E, Shiban A, Song S, Attisano L. MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells. EMBO Rep. 2017;18:420-436 pubmed publisher
  • immunohistochemistry; human; fig 9d
Gouveia R, González Andrades E, Cardona J, González Gallardo C, Ionescu A, Garzon I, et al. Controlling the 3D architecture of Self-Lifting Auto-generated Tissue Equivalents (SLATEs) for optimized corneal graft composition and stability. Biomaterials. 2017;121:205-219 pubmed publisher
  • immunocytochemistry; mouse; fig 1b
Moroishi T, Hayashi T, Pan W, Fujita Y, Holt M, Qin J, et al. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016;167:1525-1539.e17 pubmed publisher
  • immunohistochemistry; mouse; 1:200
  • western blot; mouse; 1:1000
Martin K, Pritchett J, Llewellyn J, Mullan A, Athwal V, Dobie R, et al. PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis. Nat Commun. 2016;7:12502 pubmed publisher
  • immunocytochemistry; human; 1:75; fig s6
  • immunohistochemistry; human; 1:250
  • western blot; human; 1:500; fig 6a
Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, et al. Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Nat Commun. 2016;7:12237 pubmed publisher
  • immunohistochemistry; mouse; 1:150; fig 5
  • western blot; mouse; 1:2000; fig 5
Reginensi A, Enderle L, Gregorieff A, Johnson R, Wrana J, McNeill H. A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nat Commun. 2016;7:12309 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 2b
Mihajlovic A, Bruce A. Rho-associated protein kinase regulates subcellular localisation of Angiomotin and Hippo-signalling during preimplantation mouse embryo development. Reprod Biomed Online. 2016;33:381-90 pubmed publisher
  • immunocytochemistry; human; fig 5
  • western blot; human; fig 4
Ni T, Kuperwasser C. Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer. elife. 2016;5: pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig 1
Elosegui Artola A, Oria R, Chen Y, Kosmalska A, Pérez González C, Castro N, et al. Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity. Nat Cell Biol. 2016;18:540-8 pubmed publisher
  • immunocytochemistry; mouse; 1:50; fig 3c
Cozzolino A, Noce V, Battistelli C, Marchetti A, Grassi G, Cicchini C, et al. Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes. Stem Cells Int. 2016;2016:5481493 pubmed publisher
  • immunohistochemistry; human; fig 1h
  • western blot; human; loading ...; fig s1a
Thongon N, Castiglioni I, Zucal C, Latorre E, D Agostino V, Bauer I, et al. The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level. Oncotarget. 2016;7:26551-66 pubmed publisher
  • immunocytochemistry; human; 1:400; fig 4
  • western blot; human; 1:1000; fig 3
Lehmann W, Mossmann D, Kleemann J, Mock K, Meisinger C, Brummer T, et al. ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types. Nat Commun. 2016;7:10498 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 4
  • western blot; human; 1:1000; fig 1
Meng Z, Moroishi T, Mottier Pavie V, Plouffe S, Hansen C, Hong A, et al. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun. 2015;6:8357 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 7
  • western blot; human; 1:500; fig 7
Choi H, Zhang H, Park H, Choi K, Lee H, Agrawal V, et al. Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2. Nat Commun. 2015;6:6943 pubmed publisher
  • other; human; 1:200; loading ...
  • western blot; human; 1:200; loading ...
Wang M, Liu Y, Zou J, Yang R, Xuan F, Wang Y, et al. Transcriptional co-activator TAZ sustains proliferation and tumorigenicity of neuroblastoma by targeting CTGF and PDGF-β. Oncotarget. 2015;6:9517-30 pubmed
  • immunoprecipitation; human; fig 2
  • western blot; human; fig 2
Young K, Tweedie E, Conley B, Ames J, FitzSimons M, Brooks P, et al. BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses. PLoS ONE. 2015;10:e0122892 pubmed publisher
  • western blot; human; loading ...; fig 4d
Enzo E, Santinon G, Pocaterra A, Aragona M, Bresolin S, Forcato M, et al. Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J. 2015;34:1349-70 pubmed publisher
  • western blot; human
Ito T, Taniguchi H, Fukagai K, Okamuro S, Kobayashi A. Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis. PLoS ONE. 2015;10:e0118336 pubmed publisher
  • western blot; human; loading ...; fig 3b
Lin L, Sabnis A, Chan E, Olivas V, Cade L, Pazarentzos E, et al. The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. Nat Genet. 2015;47:250-6 pubmed publisher
  • western blot; human; 1:1000
Shen Z, Stanger B. YAP regulates S-phase entry in endothelial cells. PLoS ONE. 2015;10:e0117522 pubmed publisher
  • western blot; human
Machado Neto J, Lazarini M, Favaro P, de Melo Campos P, Scopim Ribeiro R, Franchi Junior G, et al. ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells. Biochim Biophys Acta. 2015;1853:583-93 pubmed publisher
  • western blot; mouse; fig 6j
Li Q, Li S, Mana Capelli S, Roth Flach R, Danai L, Amcheslavsky A, et al. The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila. Dev Cell. 2014;31:291-304 pubmed publisher
  • immunocytochemistry; mouse; fig 8
Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 2014;211:2249-63 pubmed publisher
  • immunocytochemistry; human
Yu W, Qiao Y, Tang X, Ma L, Wang Y, Zhang X, et al. Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells. Cell Signal. 2014;26:2961-8 pubmed publisher
  • immunoprecipitation; human; fig 5
  • western blot; human; fig 5
Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP/TAZ incorporation in the ?-catenin destruction complex orchestrates the Wnt response. Cell. 2014;158:157-70 pubmed publisher
  • western blot; human
Machado Neto J, Lazarini M, Favaro P, Franchi G, Nowill A, Saad S, et al. ANKHD1, a novel component of the Hippo signaling pathway, promotes YAP1 activation and cell cycle progression in prostate cancer cells. Exp Cell Res. 2014;324:137-45 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 1
  • western blot; mouse; fig s15
Reginensi A, Scott R, Gregorieff A, Bagherie Lachidan M, Chung C, Lim D, et al. Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet. 2013;9:e1003380 pubmed publisher
Beedle A, Jaganathan A, Albajar Sigal xe9 s A, Yavitt F, Bera K, Andreu I, et al. Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton. bioRxiv. 2023;: pubmed publisher
Conway J, Isomursu A, Follain G, H xe4 rm xe4 V, Jou Oll xe9 E, Pasquier N, et al. Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling. Proc Natl Acad Sci U S A. 2023;120:e2304288120 pubmed publisher
El Yousfi Y, Mora Molina R, L xf3 pez Rivas A, Yerbes R. Role of the YAP/TAZ-TEAD Transcriptional Complex in the Metabolic Control of TRAIL Sensitivity by the Mevalonate Pathway in Cancer Cells. Cells. 2023;12: pubmed publisher
Kechagia Z, S xe1 ez P, G xf3 mez Gonz xe1 lez M, Canales B, Viswanadha S, Zamarbide M, et al. The laminin-keratin link shields the nucleus from mechanical deformation and signalling. Nat Mater. 2023;22:1409-1420 pubmed publisher
Baschieri F, Illand A, Barbazan J, Zajac O, Henon C, Loew D, et al. Fibroblasts generate topographical cues that steer cancer cell migration. Sci Adv. 2023;9:eade2120 pubmed publisher
Newman P, Yip Q, Osteil P, Anderson T, Sun J, Kempe D, et al. Programming of Multicellular Patterning with Mechano-Chemically Microstructured Cell Niches. Adv Sci (Weinh). 2023;10:e2204741 pubmed publisher
Frost T, Gartin A, Liu M, Cheng J, Dharaneeswaran H, Keskin D, et al. YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma. J Clin Invest. 2023;133: pubmed publisher
Ippolito F, Consalvi V, Noce V, Battistelli C, Cicchini C, Tripodi M, et al. Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity. Cell Death Dis. 2023;14:32 pubmed publisher
Lolo F, Walani N, Seemann E, Zalvidea D, Pav xf3 n D, Cojoc G, et al. Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system. Nat Cell Biol. 2022;: pubmed publisher
Hu L, Sun Y, Liu S, Erb H, Singh A, Mao J, et al. Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. elife. 2022;11: pubmed publisher
Caire R, Audoux E, Thomas M, Dalix E, Peyron A, Rodriguez K, et al. YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro. Nat Commun. 2022;13:6995 pubmed publisher
Chen H, Gesumaria L, Park Y, Oliver T, Singer D, Ge K, et al. BET Inhibitors Target the SCLC-N subtype of Small Cell Lung Cancer by Blocking NEUROD1 Transactivation. Mol Cancer Res. 2022;: pubmed publisher
Bera K, Kiepas A, Godet I, Li Y, Mehta P, Ifemembi B, et al. Extracellular fluid viscosity enhances cell migration and cancer dissemination. Nature. 2022;611:365-373 pubmed publisher
Jana A, Tran A, Gill A, Kiepas A, Kapania R, Konstantopoulos K, et al. Sculpting Rupture-Free Nuclear Shapes in Fibrous Environments. Adv Sci (Weinh). 2022;9:e2203011 pubmed publisher
Vittoria M, Kingston N, Kotynková K, Xia E, Hong R, Huang L, et al. Inactivation of the Hippo tumor suppressor pathway promotes melanoma. Nat Commun. 2022;13:3732 pubmed publisher
Peussa H, Kreutzer J, Mäntylä E, Mäki A, Nymark S, Kallio P, et al. Pneumatic equiaxial compression device for mechanical manipulation of epithelial cell packing and physiology. PLoS ONE. 2022;17:e0268570 pubmed publisher
Cho K, Kim N, Seo S, Song S, Jeong C, Kim H, et al. A micellized bone morphogenetic protein-7 prodrug ameliorates liver fibrosis by suppressing transforming growth factor-β signaling. Am J Cancer Res. 2022;12:763-778 pubmed
Zheng L, Luo C, Yang N, Pei H, Ji M, Shu Y, et al. Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction. Cell Death Dis. 2022;13:209 pubmed publisher
Prechova M, Adamova Z, Schweizer A, Maninová M, Bauer A, Kah D, et al. Plectin-mediated cytoskeletal crosstalk controls cell tension and cohesion in epithelial sheets. J Cell Biol. 2022;221: pubmed publisher
Park S, Frake R, Karabiyik C, Son S, Siddiqi F, Bento C, et al. Vinexin contributes to autophagic decline in brain ageing across species. Cell Death Differ. 2021;: pubmed publisher
Zhu B, Finch Edmondson M, Leong K, Zhang X, V M, Lin Q, et al. LncRNA SFTA1P mediates positive feedback regulation of the Hippo-YAP/TAZ signaling pathway in non-small cell lung cancer. Cell Death Discov. 2021;7:369 pubmed publisher
Kang H, Seo Y, Yun J, Song S, Han D, Cho E, et al. Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer. Cancers (Basel). 2021;13: pubmed publisher
Yang X, Nanayakkara J, Claypool D, Saghafinia S, Wong J, Xu M, et al. A miR-375/YAP axis regulates neuroendocrine differentiation and tumorigenesis in lung carcinoid cells. Sci Rep. 2021;11:10455 pubmed publisher
Uneda A, Kurozumi K, Fujimura A, Fujii K, Ishida J, Shimazu Y, et al. Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. Acta Neuropathol Commun. 2021;9:29 pubmed publisher
Torres Ayuso P, An E, Nyswaner K, Bensen R, Ritt D, Specht S, et al. TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin. Cancer Discov. 2021;: pubmed publisher
Li T, Guo T, Liu H, Jiang H, Wang Y. Platelet‑derived growth factor‑BB mediates pancreatic cancer malignancy via regulation of the Hippo/Yes‑associated protein signaling pathway. Oncol Rep. 2021;45:83-94 pubmed publisher
Park J, Jun K, Choi Y, Yoon E, Kim W, Jang Y, et al. CORO7 functions as a scaffold protein for the core kinase complex assembly of the Hippo pathway. J Biol Chem. 2021;296:100040 pubmed publisher
Wiggan O, DeLuca J, Stasevich T, Bamburg J. Lamin A/C deficiency enables increased myosin-II bipolar filament ensembles that promote divergent actomyosin network anomalies through self-organization. Mol Biol Cell. 2020;31:2363-2378 pubmed publisher
Panciera T, Citron A, Di Biagio D, Battilana G, Gandin A, Giulitti S, et al. Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties. Nat Mater. 2020;19:797-806 pubmed publisher
Irie K, Nagai T, Mizuno K. Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP. J Biol Chem. 2020;295:3017-3028 pubmed publisher
You E, Ko P, Jeong J, Keum S, Kim J, Seo Y, et al. Dynein-mediated nuclear translocation of yes-associated protein through microtubule acetylation controls fibroblast activation. Cell Mol Life Sci. 2020;: pubmed publisher
Jain P, Guerreiro P, Canato S, Janody F. The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis. Sci Rep. 2019;9:19843 pubmed publisher
Lee J, Dominguez A, Nam S, Stowers R, Qi L, Chaudhuri O. Identification of cell context-dependent YAP-associated proteins reveals β1 and β4 integrin mediate YAP translocation independently of cell spreading. Sci Rep. 2019;9:17188 pubmed publisher
Sayedyahossein S, Hedman A, Sacks D. Insulin suppresses transcriptional activity of yes-associated protein in insulin target cells. Mol Biol Cell. 2020;31:131-141 pubmed publisher
Fearing B, Jing L, Barcellona M, Witte S, Buchowski J, Zebala L, et al. Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape. FASEB J. 2019;33:14022-14035 pubmed publisher
Li R, Zhong C, Yu Y, Liu H, Sakurai M, Yu L, et al. Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. Cell. 2019;179:687-702.e18 pubmed publisher
Borreguero Muñoz N, Fletcher G, Aguilar Aragon M, Elbediwy A, Vincent Mistiaen Z, Thompson B. The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth. PLoS Biol. 2019;17:e3000509 pubmed publisher
Stanton A, Tong X, Yang F. Varying solvent type modulates collagen coating and stem cell mechanotransduction on hydrogel substrates. APL Bioeng. 2019;3:036108 pubmed publisher
Sliogeryte K, Gavara N. Vimentin Plays a Crucial Role in Fibroblast Ageing by Regulating Biophysical Properties and Cell Migration. Cells. 2019;8: pubmed publisher
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product information
Catalog Number :
sc-101199
Product Name :
YAP (63.7) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
63.7
Isotype :
IgG2a
Size :
100 µg/ml
List Price :
333 USD
Immunogen :
YAP
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA