product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Mfn2 (XX-1) Antibody
catalog :
sc-100560
quantity :
100 µg/ml
price :
333 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
XX-1
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 26
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:50; loading ...; fig 5c
Xu Y, Zhi F, Mao J, Peng Y, Shao N, Balboni G, et al. δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy. Aging (Albany NY). 2020;12:25035-25059 pubmed publisher
  • western blot; rat; fig 3d
Shah D, Nisr R, Stretton C, Krasteva Christ G, Hundal H. Caveolin-3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function. J Cachexia Sarcopenia Muscle. 2020;11:838-858 pubmed publisher
  • western blot; human; loading ...; fig 6c
Princely Abudu Y, Pankiv S, Mathai B, Håkon Lystad A, Bindesbøll C, Brenne H, et al. NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy. Dev Cell. 2019;49:509-525.e12 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1f
Chen K, Dai H, Yuan J, Chen J, Lin L, Zhang W, et al. Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy. Cell Death Dis. 2018;9:105 pubmed publisher
  • western blot; mouse; loading ...; fig 2e
Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, et al. mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1. Mol Cell. 2017;67:922-935.e5 pubmed publisher
  • western blot; human; loading ...; fig 1a
  • western blot; mouse; loading ...; fig 4a
Zhao F, Wang W, Wang C, Siedlak S, Fujioka H, Tang B, et al. Mfn2 protects dopaminergic neurons exposed to paraquat both in vitro and in vivo: Implications for idiopathic Parkinson's disease. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1359-1370 pubmed publisher
  • western blot; human; 1:100; loading ...; fig 1b
  • western blot; mouse; loading ...; fig 2g
Xi Q, Zhang B, Jiang Y, Zhang H, Meng Q, Chen Y, et al. Mitofusin-2 prevents skeletal muscle wasting in cancer cachexia. Oncol Lett. 2016;12:4013-4020 pubmed
  • western blot; human; loading ...; fig 2a
Janer A, Prudent J, Paupe V, Fahiminiya S, Majewski J, Sgarioto N, et al. SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome. EMBO Mol Med. 2016;8:1019-38 pubmed publisher
  • western blot; human; 1:1000; fig 4a
Martínez Pizarro A, Desviat L, Ugarte M, Perez B, Richard E. Endoplasmic Reticulum Stress and Autophagy in Homocystinuria Patients with Remethylation Defects. PLoS ONE. 2016;11:e0150357 pubmed publisher
  • western blot; human; fig 1a
Otera H, Miyata N, Kuge O, Mihara K. Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling. J Cell Biol. 2016;212:531-44 pubmed publisher
  • western blot; human; fig 1
Yu C, Liang J, Li J, Lee Y, Chang B, Su C, et al. Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. PLoS Pathog. 2015;11:e1005350 pubmed publisher
  • western blot; mouse
Wu Z, Zhu Y, Cao X, Sun S, Zhao B. Mitochondrial toxic effects of A? through mitofusins in the early pathogenesis of Alzheimer's disease. Mol Neurobiol. 2014;50:986-96 pubmed publisher
Sulkshane P, Ram J, Thakur A, Reis N, Kleifeld O, Glickman M. Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia. Redox Biol. 2021;45:102047 pubmed publisher
Han S, Zhao F, Hsia J, Ma X, Liu Y, Torres S, et al. The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering in vivo. J Cell Sci. 2021;134: pubmed publisher
Moriyama M, Koshiba T, Ichinohe T. Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nat Commun. 2019;10:4624 pubmed publisher
Catanzaro M, Weiner A, Kaminaris A, Li C, Cai F, Zhao F, et al. Doxorubicin-induced cardiomyocyte death is mediated by unchecked mitochondrial fission and mitophagy. FASEB J. 2019;33:11096-11108 pubmed publisher
Manfredi L, Ang J, Peker N, Dagda R, McFarlane C. G protein-coupled receptor kinase 2 regulates mitochondrial bioenergetics and impairs myostatin-mediated autophagy in muscle cells. Am J Physiol Cell Physiol. 2019;317:C674-C686 pubmed publisher
Crupi A, Nunnelee J, Taylor D, Thomas A, Vit J, Riera C, et al. Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging. Aging (Albany NY). 2018;10:3327-3352 pubmed publisher
Durak A, Olgar Y, Degirmenci S, Akkus E, Tuncay E, Turan B. A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats. Cardiovasc Diabetol. 2018;17:144 pubmed publisher
Brouwers B, Stephens N, Costford S, Hopf M, Ayala J, Yi F, et al. Elevated Nicotinamide Phosphoribosyl Transferase in Skeletal Muscle Augments Exercise Performance and Mitochondrial Respiratory Capacity Following Exercise Training. Front Physiol. 2018;9:704 pubmed publisher
Wiehe R, Gole B, Chatre L, Walther P, Calzia E, Ricchetti M, et al. Endonuclease G promotes mitochondrial genome cleavage and replication. Oncotarget. 2018;9:18309-18326 pubmed publisher
Czernik M, Toschi P, Zacchini F, Iuso D, Ptak G. Deregulated Expression of Mitochondrial Proteins Mfn2 and Bcnl3L in Placentae from Sheep Somatic Cell Nuclear Transfer (SCNT) Conceptuses. PLoS ONE. 2017;12:e0169579 pubmed publisher
Yamashita S, Jin X, Furukawa K, Hamasaki M, Nezu A, Otera H, et al. Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy. J Cell Biol. 2016;215:649-665 pubmed
Wang W, Wang X, Fujioka H, Hoppel C, Whone A, Caldwell M, et al. Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes. Nat Med. 2016;22:54-63 pubmed publisher
Cao Y, Lv G, Wang Y, Fan Z, Bi Y, Zhao L, et al. Mitochondrial fusion and fission after spinal sacord injury in rats. Brain Res. 2013;1522:59-66 pubmed publisher
Qi Z, Zhang Y, Guo W, Ji L, Ding S. Increased insulin sensitivity and distorted mitochondrial adaptations during muscle unloading. Int J Mol Sci. 2012;13:16971-85 pubmed publisher
product information
Catalog Number :
sc-100560
Product Name :
Mfn2 (XX-1) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
XX-1
Isotype :
IgG2a
Size :
100 µg/ml
List Price :
333 USD
Immunogen :
Mfn2
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA