ATRIP Phospho S239 Antibody | Rockland Immunochemicals 600-401-W95 product information

product summary

company name :

Rockland Immunochemicals

product type :

antibody

product name :

ATRIP Phospho S239 Antibody

catalog :

600-401-W95

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA

more info or order :

Rockland Immunochemicals product webpage

product information

Catalog Number :

600-401-W95

Name :

Anti-ATRIP pS239 (RABBIT) Antibody 600-401-W95

Display Name :

ATRIP Phospho S239 Antibody

Application Note :

Anti-ATRIP Phospho-Ser239 Antibody is suitable for WB. Expect a band at approximately ~86 kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user. The antibody also recognizes a band at ~32k.

Buffer :

0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Clonality :

Polyclonal

Conjugation :

(None)

Size :

100 µL

Default Unit :

ELISA Dilution :

1:5,000

Western Blot Dilution :

1:500

Expiration :

Expiration date is one (1) year from date of opening.

Format :

IgG

Gene Name :

ATRIP

Host Animal :

Rabbit

General Disclaimer Note :

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Immunogen :

Anti-Phospho-Ser239 ATRIP Antibody was produced from rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser239 of human ATRIP conjugated to KLH.

Packing Type :

Wet Ice

Physical State :

Liquid (sterile filtered)

Purity and Specificity :

Anti-ATRIP pS239 Antibody is directed against human ATRIP protein phosphorylated at S239. The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. This antibody is specific for phosphorylated ATRIP. Minimal reactivity occurs against non-phosphorylated ATRIP. Reactivity against ATRIP occurs from mouse sources. However, reactivity is also expected against bovine, human, non-human primate and sheep.

Species Reactivity :

mouse

Stabilizer :

0.1 mg/ml Bovine Serum Albumin (BSA) - IgG and Protease free, 50% (v/v) Glycerol

Storage :

Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.

Synonyms :

ATM, Rad3-related-interacting protein, ATR-interacting protein

Target Species :

Human

Background :

ATRIP, ATR interacting protein, binds to ATR to regulate ATR expression, and is an essential component of the DNA damage checkpoint pathway (Cortez et al, 2001). ATR is recruited to DNA lesions in part through its association with ATRIP, which in turn interacts with the single-stranded DNA binding protein RPA (Ball et al, 2007). DNA replication forks may stall as a result of DNA damage causing phosphorylation of several proteins, including BRCA1 when colocalizing with ATR/ATRIP complex and RPA (Venere et al, 2007). The DNA replication fork stall coincides with BRCA1 directly phosphorylating ATRIP at ser239. ATRIP pS239 Antibody is ideal for researchers interested in cancer research.

Immunogen Type :

Peptide

Low Endotoxin :

Post Translational Modification :

Phosphorylation

Sample Size :

Target Domain of Reactivity :

Internal

Application Text :

ELISA,Western Blot,

Category :

Primary Antibodies

Conjugation Name :

Unconjugated

UniProt :

Q8WXE1

NCBI :

NP_001257951.1

more info or order :

Rockland Immunochemicals product webpage