Edg6 Antibody | Rockland Immunochemicals 600-401-I18 product information

product summary

company name :

Rockland Immunochemicals

product type :

antibody

product name :

Edg6 Antibody

catalog :

600-401-I18

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

application :

western blot

more info or order :

Rockland Immunochemicals product webpage

product information

Catalog Number :

600-401-I18

Name :

Anti-Edg6 (RABBIT) Antibody - 600-401-I18

Display Name :

Edg6 Antibody

Application Note :

Anti-Edg6 is suitable for use in IF/ICC and WB. Expect a band approximately 35kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Buffer :

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Clonality :

Polyclonal

Concentration Value :

1.0 mg/mL

Concentration Definition :

by UV absorbance at 280 nm

Conjugation :

(None)

Size :

100 µg

Default Unit :

µg

Western Blot Dilution :

1:500-1:1000

Expiration :

Expiration date is one (1) year from date of opening.

Format :

IgG

Gene Name :

S1PR4

Host Animal :

Rabbit

General Disclaimer Note :

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Immunogen :

Edg6 Antibody was produced from whole rabbit serum prepared by repeated immunizations with the n-terminus amino acid portion of human Edg6 protein.

Packing Type :

Dry Ice

Physical State :

Liquid

Preservative :

0.05% (w/v) Sodium Azide

Purity and Specificity :

Anti-Edg6 Antibody was purified by affinity chromatography. A BLAST analysis was used to suggest cross-reactivity with Edg6 from human, mouse and rat based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Edg6 from other sources has not been determined.

Species Reactivity :

Human

Stabilizer :

0.05% BSA

Storage :

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Subclass :

IgG

Synonyms :

EDG6, Sphingosine 1-phosphate receptor 4, S1P receptor 4, S1P4, Endothelial differentiation G-protein coupled receptor 6, Sphingosine 1-phosphate receptor Edg-6, S1P receptor Edg-6, Sphingolipid Receptor Edg6 S1P4

Target Species :

Human

Background :

Anti-Edg6 detects human and mouse Sphingolipid Receptor Edg6 S1P4. Edg6 is a recently cloned member of the endothelial differentiation gene (EDG) G protein-coupled receptor family. It is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P), which are structurally related lysophospholipid mediators. Binding of SPP to Edg6 activates Erk, leading to the activation of the transcription factor Elk1 and thus the mitogen-activated protein kinase (MAPK) signal transduction pathway. The protein also acts as a receptor for a lipid-derived ligand. Edg6 plays an essential role in lymphocyte cell signaling. The protein is specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Human Edg6 gene is intronless and is mapped to chromosome 19p13.3 at the D19S120 marker. Anti-Sphingolipid Receptor Edg6 S1P4 antibody is ideal for investigators involved in neurobiology.

Immunogen Type :

Peptide

Low Endotoxin :

Sample Size :

Target Domain of Reactivity :

N-Terminus

Application Text :

Western Blot,

Category :

Primary Antibodies

Conjugation Name :

Unconjugated

UniProt :

O95977

more info or order :

Rockland Immunochemicals product webpage