DR5 Antibody | Rockland Immunochemicals 600-401-G96 product information

product summary

company name :

Rockland Immunochemicals

product type :

antibody

product name :

DR5 Antibody

catalog :

600-401-G96

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

Rockland Immunochemicals product webpage

product information

Catalog Number :

600-401-G96

Name :

Anti-DR5 (RABBIT) Antibody - 600-401-G96

Display Name :

DR5 Antibody

Application Note :

Anti-DR5 Antibody is suitable for use in E, WB, IF, IHC-P and ICC. Expect a band approximately ~45 and48 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user. Positive controls used are HeLa cells, K562 cells, and MOLT4 cells.

Buffer :

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Clonality :

Polyclonal

Concentration Value :

1 mg/mL

Concentration Definition :

by UV absorbance at 280 nm

Conjugation :

(None)

Size :

100 µg

Default Unit :

µg

Immunohistochemistry Dilution :

5µg/mL

IF Microscopy Dilution :

10µg/mL

Western Blot Dilution :

0.5-1µg/mL

Expiration :

Expiration date is one (1) year from date of opening.

Format :

IgG

Gene Name :

TNFRSF10B

Host Animal :

Rabbit

General Disclaimer Note :

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Immunogen :

DR5 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to 20 amino acids near the c-terminus of human DR5 precursor. The immunogen is located within the last 50 amino acids of DR5.

Packing Type :

Dry Ice

Physical State :

Liquid (sterile filtered)

Preservative :

0.01% (w/v) Sodium Azide

Purity and Specificity :

Anti-DR5 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with DR5 with Human and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with DR5 from other sources has not been determined. Antibody has no cross reaction to DR4.

Species Reactivity :

Human, Mouse, Rat

Storage :

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Synonyms :

DR5, KILLER, TRAILR2, TRICK2, ZTNFR9

Target Species :

Human

Background :

DR5 antibody detects human DR5 precursor. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-alpha;B. Anti-DR5 antibodies are ideal for investigators involved in NFkappaB, Apoptosis, Cytokines and Growth factor research.

Immunogen Type :

Peptide

Low Endotoxin :

Sample Size :

Target Domain of Reactivity :

C-Terminus

Application Text :

Immunohistochemistry,IF Microscopy,Western Blot,

Other :

5µg/mL ICC

Category :

Primary Antibodies

Conjugation Name :

Unconjugated

UniProt :

O14763

NCBI :

NP_003833.4

more info or order :

Rockland Immunochemicals product webpage