NMDA R2C phospho S1244 Antibody | Rockland Immunochemicals 600-401-D96 product information

product summary

company name :

Rockland Immunochemicals

product type :

antibody

product name :

NMDA R2C phospho S1244 Antibody

catalog :

600-401-D96

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot

more info or order :

Rockland Immunochemicals product webpage

product information

Catalog Number :

600-401-D96

Name :

Anti-NMDA R2C pS1244 (Rabbit) Antibody - 600-401-D96

Display Name :

NMDA R2C phospho S1244 Antibody

Application Note :

Anti-NMDA R2C pS1244 Antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 140 kDa in size corresponding to the NMDA receptor phosphorylated at Ser1244 in the appropriate cell lysate or extract.

Buffer :

0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Clonality :

Polyclonal

Concentration Value :

Titrated value sufficient to run approximately 10 mini blots.

Conjugation :

(None)

Size :

100 µL

Default Unit :

Western Blot Dilution :

1:1000

Expiration :

Expiration date is one (1) year from date of opening.

Format :

IgG

Gene Name :

Grin2c

Host Animal :

Rabbit

General Disclaimer Note :

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Immunogen :

Anti-NMDA R2C pS1244 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1244.

Packing Type :

Dry Ice

Physical State :

Liquid

Purity and Specificity :

Anti-NMDA R2C pS1244 antibody is directed against NMDA R2C protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification and is specific for the phophorylated NMDA R2C protein. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide that was used to generate the antibody but not by the corresponding dephospho-peptide. Reactivity is expected from bovine, canine, human, and non-human primates. Cross reactivity from other species has not been determined.

Species Reactivity :

rat, mouse

Stabilizer :

0.1 mg/ml Bovine Serum Albumin (BSA) - IgG and Protease free, 50% (v/v) Glycerol

Storage :

Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Synonyms :

Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C

Target Species :

Rat

Background :

NMDA R2C pS1244 Antibody detects phophorylated NMDA R2C protein. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The NR2C subunit of the receptor is thought to influence the NMDAR conductance level. Phosphorylation of Ser1244 has been shown to regulate NMDA receptor channel function. Anti-NMDA R2C pS1244 Antibody is ideal for investigators involved in Neuroscience, Signal Transduction, and Cell Signaling Research.

Immunogen Type :

Peptide

Low Endotoxin :

Post Translational Modification :

Phosphorylation

Sample Size :

Target Domain of Reactivity :

Internal

Application Text :

Western Blot,

Other :

User Optimized

Category :

Primary Antibodies

Conjugation Name :

Unconjugated

UniProt :

Q00961

Primary Image Name :

Western blot of Anti-NMDA R2C pS1244 (Rabbit) Antibody - 600-401-D96

more info or order :

Rockland Immunochemicals product webpage