NMDA R1, Splice Variant N1 Antibody | Rockland Immunochemicals 600-401-D88 product information

product summary

company name :

Rockland Immunochemicals

product type :

antibody

product name :

NMDA R1, Splice Variant N1 Antibody

catalog :

600-401-D88

quantity :

25 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, immunohistochemistry

more info or order :

Rockland Immunochemicals product webpage

product information

Catalog Number :

600-401-D88

Name :

Anti-NMDA R1, Splice Variant N1 (Rabbit) Antibody - 600-401-D88

Display Name :

NMDA R1, Splice Variant N1 Antibody

Application Note :

Anti-NMDA R1, Splice Variant N1 (Rabbit) Antibody is suitable for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 120 kDa in size corresponding to the NR1 subunit, NR1 splice variant insert protein of the NMDA receptor in the appropriate cell lysate or extract.

Clonality :

Polyclonal

Concentration Value :

Titrated value sufficient to run approximately 10 mini blots.

Conjugation :

(None)

Size :

25 µg

Default Unit :

µg

Immunohistochemistry Dilution :

1:1000

Western Blot Dilution :

1:1000

Expiration :

Expiration date is one (1) year from date of opening.

Format :

IgG

Gene Name :

Grin1

Host Animal :

Rabbit

General Disclaimer Note :

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Immunogen :

Anti-NMDA NR1 Subunit, Splice Variant N1 Antibody was produced by repeated immunizations with a synthetic peptide corresponding to amino acid residues specific to the NR1 subunit, N1 splice variant insert.

Packing Type :

Ambient

Physical State :

Lyophilized

Purity and Specificity :

Anti-NMDA R1, Splice Variant N1 antibody is directed against NMDA R1 protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. This antibody does not recognize NR1 subunits of the NMDA receptor that do not contain the N1 insert. Reactivity is expected from the following species based on 100% sequence homology: canine, chicken, human, non-human primates and Xenopus.

Reconstitution Buffer :

Neutral PBS

Reconstitution Volume :

50µL

Species Reactivity :

rat, mouse

Storage :

Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.

Synonyms :

Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1, NMD-R1, Grin1

Target Species :

Rat

Background :

NMDA R1, Splice Variant N1 Antibody detects NMDA R1 protein. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA Receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. There are a number of different splice variants of the NR1-Subunit. Differential splicing of three exons in the NR1-Subunit generates up to eight NR1-Subunit splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR. Anti-NMDA R1, Splice Variant N1 Antibody is ideal for investigators involved in Neuroscience and Signal Transduction research.

Immunogen Type :

Peptide

Low Endotoxin :

Sample Size :

Target Domain of Reactivity :

Internal

Application Text :

Immunohistochemistry,Western Blot,

Other :

User Optimized

Category :

Primary Antibodies

Conjugation Name :

Unconjugated

UniProt :

P35439

NCBI :

NP_058706.1

Primary Image Name :

Western blot of Anti-NMDA R1, Splice Variant N1 (Rabbit) Antibody - 600-401-D88

more info or order :

Rockland Immunochemicals product webpage