Interferon alpha Receptor Type I phospho S535/phospho S539 Antibody | Rockland Immunochemicals 600-401-D67 product information

product summary

company name :

Rockland Immunochemicals

product type :

antibody

product name :

Interferon alpha Receptor Type I phospho S535/phospho S539 Antibody

catalog :

600-401-D67

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

Rockland Immunochemicals product webpage

product information

Catalog Number :

600-401-D67

Name :

Anti-Interferon alpha Receptor Type I pS535/pS539 (Rabbit) Antibody - 600-401-D67

Display Name :

Interferon alpha Receptor Type I phospho S535/phospho S539 Antibody

Application Note :

Anti-Interferon alpha Receptor Type I pS535/pS539 (Rabbit) antibody is suitable for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. The molecular weight of the IFNAR1 varies with cell line due to different levels of glycosylation in 293 and HeLa Cells; the mature form is approximately 110-130 kDa in size.

Buffer :

0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Clonality :

Polyclonal

Concentration Value :

Titrated value sufficient to run approximately 10 mini blots.

Conjugation :

(None)

Size :

100 µL

Default Unit :

Immunohistochemistry Dilution :

1:1000

Western Blot Dilution :

1:1000

Expiration :

Expiration date is one (1) year from date of opening.

Format :

IgG

Gene Name :

IFNAR1

Host Animal :

Rabbit

General Disclaimer Note :

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Immunogen :

Anti-Interferon alpha Receptor Type I pS535/pS539 Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser535/539.

Other Performance Data :

Titrated value sufficient to run approximately 10 mini blots.

Packing Type :

Dry Ice

Physical State :

Liquid

Purity and Specificity :

Anti-Interferon alpha Receptor Type I pS535/pS539 Antibody is directed against human Interferon alpha Receptor Type I phopshorylated at positions S535/S539. The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. Expect reactivity with the following species based on sequence homology: bovine, canine, human, mouse, non-human primates, rat, and sheep. Cross reactivity with Interferon alpha Receptor Type I phospho S535/phospho S539 antibody from other species has not been determined.

Species Reactivity :

human

Stabilizer :

0.1 mg/ml Bovine Serum Albumin (BSA) - IgG and Protease free, 50% (v/v) Glycerol

Storage :

Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Synonyms :

Interferon alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1

Target Species :

Human

Background :

Interferon alpha Receptor Type I pS535/pS539 Antibody detects Interferon alpha Receptor Type I phopshorylated at positions S535/S539. Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon-α Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1. Therefore, Interferon alpha Receptor Type I phospho S535/phospho S539 antibody is ideal for investigators involved in Cell Signaling, Virology, Immunology and Cancer Research.

Immunogen Type :

Peptide

Low Endotoxin :

Post Translational Modification :

Phosphorylation

Sample Size :

Target Domain of Reactivity :

Internal

Application Text :

Immunohistochemistry,Western Blot,

Other :

Dot Blot: 1:1000

Category :

Primary Antibodies

Conjugation Name :

Unconjugated

UniProt :

P17181

Primary Image Name :

Western Blot of Anti-Interferon alpha Receptor Type I pS535/pS539 (Rabbit) Antibody - 600-401-D67

more info or order :

Rockland Immunochemicals product webpage