MPYS Antibody | Rockland Immunochemicals 600-401-C08 product information

product summary

company name :

Rockland Immunochemicals

product type :

antibody

product name :

MPYS Antibody

catalog :

600-401-C08

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA

more info or order :

Rockland Immunochemicals product webpage

product information

Catalog Number :

600-401-C08

Name :

Anti-MPYS (Rabbit) Antibody - 600-401-C08

Display Name :

MPYS Antibody

Application Note :

Anti-MPYS antibody has been tested in ELISA, WB, and ICC. Specific conditions for reactivity should be optimized by the end user. Expect a band at ~37-42 kDa in size corresponding to MPYS by Western blotting in the appropriate cell lysate or extract. A20 cell lysate may be used as positive control.

Buffer :

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Clonality :

Polyclonal

Concentration Value :

1.0 mg/mL

Concentration Definition :

by UV absorbance at 280 nm

Conjugation :

(None)

Size :

100 µg

Default Unit :

µg

ELISA Dilution :

1:10,000 - 1:40,000

Western Blot Dilution :

1.0 - 2.0 µg/mL

Expiration :

Expiration date is one (1) year from date of opening.

Format :

IgG

Gene Name :

TMEM173

Host Animal :

Rabbit

General Disclaimer Note :

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Immunogen :

MPYS Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide near the c-terminus of human MPYS.

Packing Type :

Dry Ice

Physical State :

Liquid (sterile filtered)

Preservative :

0.01% (w/v) Sodium Azide

Purity and Specificity :

Anti-MPYS Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with MPYS with Human and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with MPYS from other sources has not been determined.

Species Reactivity :

Human, mouse

Storage :

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Synonyms :

MPYS, Transmembrane protein 173, TMEM173, ERIS, MITA, STING, Stimulator of interferon genes protein, hSTING, Mediator of IRF3 activation

Target Species :

Human

Background :

MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist. Anti-MYPS antibody is ideal for investigators involved transcription factor and infectious diease.

Immunogen Type :

Peptide

Low Endotoxin :

Sample Size :

Target Domain of Reactivity :

C-Terminus

Application Text :

ELISA,Western Blot,

Other :

ICC: 5.0 µg/mL

Category :

Primary Antibodies

Conjugation Name :

Unconjugated

UniProt :

Q86WV6

NCBI :

NP_938023

Primary Image Name :

Anti-MPYS Antibody - Immunocytochemistry

more info or order :

Rockland Immunochemicals product webpage