product summary
Loading...
company name :
Rockland Immunochemicals
product type :
antibody
product name :
DC-SIGN Monoclonal Antibody
catalog :
600-301-G94
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
5D7
reactivity :
human
application :
western blot, immunohistochemistry
more info or order :
Rockland Immunochemicals product webpage
product information
Catalog Number :
600-301-G94
Name :
Anti-DC-SIGN (MOUSE) Monoclonal Antibody - 600-301-G94
Display Name :
DC-SIGN Monoclonal Antibody
Application Note :
Anti-DC-SIGN Monoclonal Antibody is suitable for use in ELISA, Western Blot, and Immunohistochemistry. Expect a band approximately ~45.7 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user. Validated in human samples. All other applications and species not yet tested.
Buffer :
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Clonality :
Monoclonal
Clone ID :
5D7
Concentration Value :
1 mg/mL
Concentration Definition :
by UV absorbance at 280 nm
Conjugation :
(None)
Size :
100 µg
Default Unit :
µg
Immunohistochemistry Dilution :
5-10µg/mL
Western Blot Dilution :
1-2 ug/mL
Expiration :
Expiration date is one (1) year from date of opening.
Format :
IgG
Gene Name :
CD209
Host Animal :
Mouse
General Disclaimer Note :
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
Immunogen :
DC-SIGN monoclonal antibody was produced in mice by repeated immunizations with a recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.
Packing Type :
Dry Ice
Physical State :
Liquid (sterile filtered)
Preservative :
0.01% (w/v) Sodium Azide
Purity and Specificity :
Anti-DC-SIGN Monoclonal Antibody was Immunoaffinity chromatography purified. A BLAST analysis was used to suggest cross-reactivity with DC-SIGN with Human based on 100% homology with the immunizing sequence. Cross-reactivity with DC-SIGN from other sources has not been determined.
Species Reactivity :
Human
Storage :
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Synonyms :
DC-SIGN (5D7), Dendritic cell-specific ICAM-3-grabbing nonintegrin 1,CLEC4L
Target Species :
Human
Background :
DC-SIGN Monoclonal antibody detects human DC-SIGN. Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes , where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum. Anti-DC-SIGN Monoclonal antibodies are ideal for investigators involved in infectious disease research.
Immunogen Type :
Recombinant Protein
Low Endotoxin :
No
Sample Size :
No
Target Domain of Reactivity :
Extracellular
Application Text :
Immunohistochemistry,Western Blot,
Category :
Primary Antibodies
Conjugation Name :
Unconjugated
UniProt :
Q9UBN6
more info or order :
Rockland Immunochemicals product webpage
company information
Rockland Immunochemicals
321 Jones Blvd
Pottstown, PA 19464
tech@rockland.com
https://www.rockland.com/
484-791-3823
headquarters: USA
Rockland Immunochemicals, Inc. produces Phosho-Site Specific Antibodies and Antibody based tools for basic, applied and clinical research. Our laboratory is located west of Philadelphia, Pennsylvania, USA. The technology base of the organization is the experience of its staff scientists in the production and purification of a wide range of antibodies through monoclonal & polyclonal antibody techniques utilizing in vitro and in vivo methods. Rockland's antibodies are suited for individuals performing Western Blotting, ELISA, Immunohistochemistry, Fluorescent Microscopy, High Content Screening and diagnostic kit production. Primary antibodies include Akt Pathway, Apolipoproteins, Apoptosis/Cell Cycle, Cytokines, Cell Signaling, Enzymes, Extracellular Matrix, Transcription Factors (NFkB) and Ubiquitin.