CDKN2A Antibody | Rockland Immunochemicals 200-901-AJ8 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Rockland Immunochemicals

product type :

antibody

product name :

CDKN2A Antibody

catalog :

200-901-AJ8

quantity :

100 ug

price :

329.00 USD

clonality :

polyclonal

host :

chicken

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA

product information

Catalog Number :

200-901-AJ8

Name :

Anti-CDKN2A (CHICKEN) Antibody - 200-901-AJ8

Display Name :

CDKN2A Antibody

Application Note :

Anti-CDKN2A Antibody has been tested for use in ELISA, Western Blotting and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 17 kDa in Western Blots of specific cell lysates and tissues.

Buffer :

0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2

Clonality :

Polyclonal

Concentration Value :

1 mg/mL

Concentration Definition :

by UV absorbance at 280 nm

Conjugation :

(None)

Size :

100 ug

Default Unit :

ELISA Dilution :

1:10,000-1:20,000

IF Microscopy Dilution :

20 _g/mL

Western Blot Dilution :

1-2 _g/mL

Expiration :

Expiration date is one (1) year from date of opening.

Format :

IgY

Gene Name :

CDKN2A

Host Animal :

Chicken

General Disclaimer Note :

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Immunogen :

Anti-CDKN2A antibody was prepared from whole chicken serum produced by repeated immunizations with an 18 amino acid synthetic peptide from near the N-terminus of human CDKN2A.

Packing Type :

Dry Ice

Physical State :

Liquid (sterile filtered)

Preservative :

0.02% (w/v) Sodium Azide

Purity and Specificity :

Anti-CDKN2A Antibody is an IgY fraction antibody purified from monospecific chicken egg yolks by a multi-step process which includes selective precipitation and salt fractionation followed by extensive dialysis against the buffer stated above. Cross reactivity with CDKN2A from other sources has not been determined.

Species Reactivity :

Human, mouse, rat

Storage :

Store vial at -20 xA1 C prior to opening. Aliquot contents and freeze at -20 xA1 C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 xA1 C as an undiluted liquid. Dilute only prior to immediate use.

Synonyms :

CDKN2A Antibody, ARF, MLM, P14, P16, P19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4A, MTS-1, P14ARF, P19ARF, P16INK4, P16INK4A, P16-INK4A, Cyclin-dependent kinase 4 inhibitor A

Target Species :

Human

Background :

The CDKN2A locus gives rise to 2 distinct transcripts from different promoters. The transcripts have been designated p16(INK4A) and p14(ARF). This chromosomal region undergoes a number of inversions, translocations, heterozygous deletions, and homozygous deletions in a variety of malignant cell lines including those from glioma, non-small cell lung cancer, leukemia, and melanoma. Deletion of the region containing CDKN2A is found in more than half of all melanoma cell lines. Conversely, transfection of CDKN2A suppressed the growth of two independent mesothelioma cell lines, suggesting that inactivation of the CDKN2 gene is an essential step in the etiology of malignant mesotheliomas. CDKN2A induces a G1 cell cycle arrest by inhibiting the phosphorylation of the Rb protein by the cyclin-dependent kinases CDK4 and CDK6. CDKN2A is expressed as at least three distinct isoforms.

Immunogen Type :

Peptide

Low Endotoxin :

Sample Size :

Target Domain of Reactivity :

N-Terminus

Created On :

10/4/2014 12:10 AM

Modified On :

6/29/2015 9:59 AM

Application Text :

ELISA,IF Microscopy,Western Blot

Category :

Primary Antibodies

Conjugation Name :

Unconjugated

2015 List Price :

319.00

2016 List Price :

329.00 USD

Uniprot :

P42771

NCBI :

NP_000068