Nur77 Antibody | Rockland Immunochemicals 200-401-H99 product information

product summary

company name :

Rockland Immunochemicals

product type :

antibody

product name :

Nur77 Antibody

catalog :

200-401-H99

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

more info or order :

Rockland Immunochemicals product webpage

product information

Catalog Number :

200-401-H99

Name :

Anti-Nur77 (RABBIT) Antibody - 200-401-H99

Display Name :

Nur77 Antibody

Application Note :

Anti Nur77 antibody is suitable for use in ChIP, IF/ICC, IP and WB. Expect a band approximately 71kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Buffer :

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Clonality :

Polyclonal

Concentration Value :

1.0 mg/mL

Concentration Definition :

by UV absorbance at 280 nm

Conjugation :

(None)

Size :

100 µg

Default Unit :

µg

Western Blot Dilution :

1:500-1:1000

Expiration :

Expiration date is one (1) year from date of opening.

Format :

IgG

Gene Name :

NR4A1

Host Animal :

Rabbit

General Disclaimer Note :

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Immunogen :

Nur77 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to internal amino acids with human Nur77 protein.

Packing Type :

Dry Ice

Physical State :

Liquid

Preservative :

0.05% (w/v) Sodium Azide

Purity and Specificity :

Anti-Nur77 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-Nur77 from human and mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Nur77 from other sources has not been determined.

Species Reactivity :

Mouse

Stabilizer :

0.05% BSA

Storage :

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Subclass :

IgG

Synonyms :

GFRP1, HMR, NAK1, Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3

Target Species :

Human

Background :

Anti Nur7 antibody detects human Nur77. Nur77 (Nak-1,TR3) is a member of the NR4A orphan nuclear receptor (NR) superfamily of transcription factors. The Nur77 ligand has not yet been identified. It is thought that the lack of ability to identify a ligand may be due to the lack of a typical NR binding pocket in the ligand binding domain. Nur77, like other NR4A receptors, are immediate-early genes induced by diverse stimuli in multiple tissues. There is increasing evidence that Nur77 and other NR4A receptors play important roles in maintaining tissue homeostasis. For example, specific Nur77 functions have been defined in the brain, T-cells/thymocytes, adipose tissue, steroidgenesis, muscle, blood vessels, macrophages and cardiovascular system. There is also evidence that Nur77 plays roles in pathological processes such as cancer. Nur77 is a phosphoprotein and its size ranges from ~65 kDa to 90 kDa depending on the isoform expressed and level of phosphorylation or other post-translational modifications. Anti-Nur77 antibody is ideal for investigators involved in apoptosis.

Immunogen Type :

Peptide

Low Endotoxin :

Sample Size :

Target Domain of Reactivity :

Internal

Application Text :

Western Blot,

Category :

Primary Antibodies

Conjugation Name :

Unconjugated

UniProt :

P22736

NCBI :

NP_001189162.1

more info or order :

Rockland Immunochemicals product webpage