Malin Antibody PE/ATTO 594 | Rockland Immunochemicals 200-363-W58 product information

product summary

company name :

Rockland Immunochemicals

product type :

antibody

product name :

Malin Antibody PE/ATTO 594

catalog :

200-363-W58

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

ATTO 594

clone name :

S85-18

reactivity :

human

application :

western blot, ELISA

more info or order :

Rockland Immunochemicals product webpage

product information

Catalog Number :

200-363-W58

Name :

Anti-Malin (MOUSE) Monoclonal Antibody PE/ATTO 594 Conjugated - 200-363-W58

Display Name :

Malin Antibody PE/ATTO 594

Application Note :

Anti-Malin PE/ATTO 594 Conjugated Antibody is suited for use in Western Blots and Immunocytochemistry. Expect a band approximately ~42 kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

Buffer :

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Clonality :

Monoclonal

Clone ID :

S85-18

Concentration Value :

1mg/mL

Concentration Definition :

by UV absorbance at 280 nm

Conjugation :

AT594

Size :

100 µg

Default Unit :

µg

ELISA Dilution :

1:10,000

Western Blot Dilution :

1:1000

Expiration :

Expiration date is one (1) year from date of opening.

Format :

IgG1

Gene Name :

NHLRC1

Host Animal :

Mouse

General Disclaimer Note :

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Immunogen :

Anti-Malin Antibody was created by repeated immunization of mice with a fusion protein of amino acids 2-125 of human Malin.

Packing Type :

Dry Ice

Physical State :

Liquid (sterile filtered)

Preservative :

0.1% (w/v) Sodium Azide

Purity and Specificity :

Anti-Malin Antibody was purified from concentrated tissue culture supernate by Protein G chromatography. BLAST analysis suggests 86% similarity to rat and 77% similarity to mouse.

Species Reactivity :

Human

Stabilizer :

50% (v/v) Glycerol

Storage :

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Subclass :

IgG1

Synonyms :

E3 ubiquitin-protein ligase NHLRC1, NHLRC 1, NHL repeat containing 1, EPM2A, EPM2B, MGC119262, MGC119264, MGC119265, NHL repeat containing protein 15

Target Species :

Human

Background :

Progressive myoclonic epilepsy type 2 (EPM2), also called Lafora disease, is an autosomal recessive disease characterized by grand mal seizures and/or myoclonus at about 15 years of age. Rapid and severe mental deterioration follows, often with psychotic features. Survival is less than 10 years after onset. Starch-like, endoplasmic reticulum-associated polyglucosans, called Lafora bodies, can be observed in brain, muscle, liver and heart. One cause of Lafora disease is due to mutations in NHLRC1, the gene encoding Malin. Forty-nine different mutations in NHLRC1 have been shown to cause EPM2. Malin, also called NHL repeat-containing protein 1, is a single subunit E3 ubiquitin ligase, containing 6 NHL repeats and 1 RING-type zinc finger. Malin’s RING domain is responsible for its ability to mediate ubiquitination. Malin interacts with and polyubiquitinates Laforin, a protein also implicated in EPM2. Malin localizes to the endoplasmic reticulum and, to a lesser extent, in the nucleus. Malin is expressed in brain, cerebellum, spinal cord, medulla, heart, liver, skeletal muscle and pancreas. Anti-Malin is ideal for researchers interested in Neuroscience, including Neuroleptic malignant syndrome, and pathways related to antigen processing, ubiquination and proteosome degradation.

Immunogen Type :

Recombinant Protein

Low Endotoxin :

Sample Size :

Target Domain of Reactivity :

N-Terminus

Application Text :

ELISA,Western Blot,

Category :

Primary Antibodies

Conjugation Name :

ATTO 594

UniProt :

Q6VVB1

NCBI :

NP_940988

more info or order :

Rockland Immunochemicals product webpage