GRK (pan) Antibody | Rockland Immunochemicals 200-301-W63 product information

product summary

company name :

Rockland Immunochemicals

product type :

antibody

product name :

GRK (pan) Antibody

catalog :

200-301-W63

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S145-20

reactivity :

human, mouse, rat

application :

western blot, ELISA

more info or order :

Rockland Immunochemicals product webpage

product information

Catalog Number :

200-301-W63

Name :

Anti-GRK (pan) (MOUSE) Monoclonal Antibody - 200-301-W63

Display Name :

GRK (pan) Antibody

Application Note :

Anti-GRK (pan) Antibody is suitable for Western Blots and Immunocytochemistry. Expect a band approximately ~70 kDa on specific lysates or tissues. Does not cross react with GRK6. Specific conditions for reactivity should be optimized by the end user.

Buffer :

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Clonality :

Monoclonal

Clone ID :

S145-20

Concentration Value :

1mg/mL

Concentration Definition :

by UV absorbance at 280 nm

Conjugation :

(None)

Size :

100 µg

Default Unit :

µg

ELISA Dilution :

1:10,000

Western Blot Dilution :

1:1000

Expiration :

Expiration date is one (1) year from date of opening.

Format :

IgG1

Gene Name :

Grk5

Host Animal :

Mouse

General Disclaimer Note :

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Immunogen :

Anti-GRK (pan) Antibody was produced by repeated immunization of mice with a fusion protein containing amino acids 381-590 of mouse GRK5.

Packing Type :

Wet Ice

Physical State :

Liquid (sterile filtered)

Preservative :

0.1% (w/v) Sodium Azide

Purity and Specificity :

Anti-GRK (pan) Antibody was purified from concentrated tissue culture supernate by Protein G chromatography. BLAST analysis suggests that it is 91% identical to human, 99% identical to rat, >55% identical to GRK6 and GRK4, and >40% identical to GRK7 and RK.

Species Reactivity :

Human, Rat, Mouse

Stabilizer :

50% (v/v) Glycerol

Storage :

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Subclass :

IgG1

Synonyms :

G protein-coupled receptor kinase, Pan-GRK, GRK-pan, GRK

Target Species :

Mouse

Background :

G protein-coupled receptor kinases (GRK) are serine/threonine kinases that phosphorylate a variety of G-protein-coupled receptors (GPCRs), specifically activated forms, including adrenergic receptors, muscarinic acetylcholine receptors, dopamine receptors and opioid receptors. GRK receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Areas of interest and use for researchers are Neuroscience, including Huntington's disease and schizoaffective disorder, Chemokine signaling, Cell Differentiation and Cell Development.

Immunogen Type :

Recombinant Protein

Low Endotoxin :

Sample Size :

Target Domain of Reactivity :

C-Terminus

Application Text :

ELISA,Western Blot,

Category :

Primary Antibodies

Conjugation Name :

Unconjugated

UniProt :

Q8VEB1

more info or order :

Rockland Immunochemicals product webpage