IP3 Receptor Antibody | Rockland Immunochemicals 200-301-F77 product information

product summary

company name :

Rockland Immunochemicals

product type :

antibody

product name :

IP3 Receptor Antibody

catalog :

200-301-F77

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S24-18

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

Rockland Immunochemicals product webpage

product information

Catalog Number :

200-301-F77

Name :

Anti-IP3 Receptor (MOUSE) Monoclonal Antibody - 200-301-F77

Display Name :

IP3 Receptor Antibody

Application Note :

Anti-IP3 Antibody is suitable for use in WB, IP, and IHC. Expect a band approximately ~300kDa on specific lysates. Does not recognize type 2 or type 3 IP3R's. Specific conditions for reactivity should be optimized by the end user.

Buffer :

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Clonality :

Monoclonal

Clone ID :

S24-18

Concentration Value :

1.0 mg/mL

Concentration Definition :

by UV absorbance at 280 nm

Conjugation :

(None)

Size :

100 µg

Default Unit :

µg

Immunohistochemistry Dilution :

0.1-1.0ug/mL

IF Microscopy Dilution :

1.0-10ug/mL

Western Blot Dilution :

1ug/mL

Expiration :

Expiration date is one (1) year from date of opening.

Format :

IgG1

Gene Name :

Itpr1

Host Animal :

Mouse

General Disclaimer Note :

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Immunogen :

IP3 Receptor Antibody was produced in mice by repeated immunizations raised against a fusion protein of the cytoplasmic carboxyl terminus region of rat type1 IP3R inositol 1,4,5-triphosphate receptor type 1, Itpr1.

Packing Type :

Dry Ice

Physical State :

Liquid (sterile filtered)

Preservative :

0.09% (w/v) Sodium Azide

Purity and Specificity :

Anti-IP3 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with IP3 from Human, Mouse, and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with IP3 from other sources has not been determined. Ion Channels research.

Species Reactivity :

Human, Mouse, Rat

Stabilizer :

50% (v/v) Glycerol

Storage :

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Subclass :

IgG1

Synonyms :

IP3 Receptor, S24-18,Inositol 1,4,5-trisphosphate receptor type 1, IP3 receptor isoform 1, IP-3-R, IP3R1,Type 1 inositol 1,4,5-trisphosphate receptor, Insp3r

Target Species :

Rat

Background :

Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family, and is located in the endoplasmic reticulum. It functions as a Ca2+ release channel for intracellular stores of calcium ions. There are three types of IP3 receptors (IP3 receptor 1, 2 and 3) that require the second messenger inositol 1,4,5-triphosphate (IP3) for activation. Four individual receptor subunits, resulting in homo- or heterooligomerization of the receptor isoform, form a functional channel. Phosphorylation of IP3R1 at Ser1756 by cyclic- AMP-dependent protein kinase A (PKA) regulates the sensitivity of IP3R1 to IP3 and may thus be a mode of regulation for Ca2+ release. IP3R1 mediated calcium release appears to have an effect on the induction of long term depression (LTD) in Purkinje cells.

Immunogen Type :

Recombinant Protein

Low Endotoxin :

Sample Size :

Target Domain of Reactivity :

C-Terminus

Application Text :

Immunohistochemistry,IF Microscopy,Western Blot,

Category :

Primary Antibodies

Conjugation Name :

Unconjugated

UniProt :

P29994

NCBI :

NP_001007236.2

Primary Image Name :

IP3 Receptor Immunohistochemistry

more info or order :

Rockland Immunochemicals product webpage