| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; fig 2
| Shamma A, Suzuki M, Hayashi N, Kobayashi M, Sasaki N, Nishiuchi T, et al. ATM mediates pRB function to control DNMT1 protein stability and DNA methylation. Mol Cell Biol. 2013;33:3113-24 pubmed publisher |
- western blot; human; 1:500; loading ...; fig s5d
| Laine A, Nagelli S, Farrington C, Butt U, Cvrljevic A, Vainonen J, et al. CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis. Cancer Res. 2021;81:4319-4331 pubmed publisher |
- western blot; mouse; 1:1000; fig s5m
| Hansen R, Mund A, Poulsen S, Sandoval M, Klement K, Tsouroula K, et al. SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. Nat Cell Biol. 2016;18:1357-1366 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 2c
| Bakr A, Köcher S, Volquardsen J, Petersen C, Borgmann K, Dikomey E, et al. Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1. Oncotarget. 2016;7:57679-57693 pubmed publisher |
- immunocytochemistry; human; 1:500; fig 5
| Qi Y, Qiu Q, Gu X, Tian Y, Zhang Y. ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts. Sci Rep. 2016;6:24700 pubmed publisher |
- western blot; human; fig 3h
| Torres M, Pandita R, Kulak O, Kumar R, Formstecher E, Horikoshi N, et al. Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. Mol Cell Biol. 2015;35:3633-45 pubmed publisher |
- western blot; mouse; fig s5
| Hartlerode A, Morgan M, Wu Y, Buis J, Ferguson D. Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors. Nat Struct Mol Biol. 2015;22:736-43 pubmed publisher |
- immunocytochemistry; mouse
| Xiong J, Todorova D, Su N, Kim J, Lee P, Shen Z, et al. Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. J Cell Biol. 2015;208:513-20 pubmed publisher |
| Xue L, Furusawa Y, Okayasu R, Miura M, Cui X, Liu C, et al. The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function. DNA Repair (Amst). 2015;25:72-83 pubmed publisher |
- western blot; human; 1:500; loading ...; fig 3a
| Wei F, Ojo D, Lin X, Wong N, He L, Yan J, et al. BMI1 attenuates etoposide-induced G2/M checkpoints via reducing ATM activation. Oncogene. 2015;34:3063-75 pubmed publisher |
- western blot; human; fig s1
| Smith C, Matheson T, Trombly D, Sun X, Campeau E, Han X, et al. A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli. Mol Biol Cell. 2014;25:2866-81 pubmed publisher |
- immunocytochemistry; human
| Manguan García C, Pintado Berninches L, Carrillo J, Machado Pinilla R, Sastre L, Perez Quilis C, et al. Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells. PLoS ONE. 2014;9:e101424 pubmed publisher |
- immunocytochemistry; human
| Birkelbach M, Ferraiolo N, Gheorghiu L, Pfäffle H, Daly B, Ebright M, et al. Detection of impaired homologous recombination repair in NSCLC cells and tissues. J Thorac Oncol. 2013;8:279-86 pubmed publisher |
- immunocytochemistry; human; 1:50
| Wu L, Shao L, Li M, Zheng J, Wang J, Feng W, et al. BMS-345541 sensitizes MCF-7 breast cancer cells to ionizing radiation by selective inhibition of homologous recombinational repair of DNA double-strand breaks. Radiat Res. 2013;179:160-70 pubmed publisher |
- western blot; mouse; 1:1000
| Pusapati R, Rounbehler R, Hong S, Powers J, Yan M, Kiguchi K, et al. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A. 2006;103:1446-51 pubmed |
| Montales K, Ruis K, Lindsay H, Michael W. MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks. PLoS ONE. 2022;17:e0271905 pubmed publisher |
| Ka N, Lim G, Hwang S, Kim S, Lee M. IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer. Cell Rep. 2021;37:110138 pubmed publisher |
| Nguyen A, Dzulko M, Murr J, Yen Y, Schneider G, Kramer O. Class 1 Histone Deacetylases and Ataxia-Telangiectasia Mutated Kinase Control the Survival of Murine Pancreatic Cancer Cells upon dNTP Depletion. Cells. 2021;10: pubmed publisher |
| Tanaka H, Kondo K, Fujita K, Homma H, Tagawa K, Jin X, et al. HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology. Commun Biol. 2021;4:1175 pubmed publisher |
| Herok M, Wawrzynow B, Maluszek M, Olszewski M, Zylicz A, Zylicz M. Chemotherapy of HER2- and MDM2-Enriched Breast Cancer Subtypes Induces Homologous Recombination DNA Repair and Chemoresistance. Cancers (Basel). 2021;13: pubmed publisher |
| Qi Y, Ma L, Naeem S, Gu X, Chao X, Yuan C, et al. Pb induced mitochondrial fission of fibroblast cells via ATM activation. J Hazard Mater. 2021;416:126177 pubmed publisher |
| Wang Y, Lee C, Shen Y, Lin P, Wu W, Lin Y, et al. Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA. Cell Rep. 2021;36:109537 pubmed publisher |
| Homma H, Tanaka H, Jin M, Jin X, Huang Y, Yoshioka Y, et al. DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis. Life Sci Alliance. 2021;4: pubmed publisher |
| Tao Y, Aparicio T, Li M, Leong K, Zha S, Gautier J. Inhibition of DNA replication initiation by silver nanoclusters. Nucleic Acids Res. 2021;49:5074-5083 pubmed publisher |
| Cabrini M, Roncador M, Galbiati A, Cipolla L, Maffia A, Iannelli F, et al. DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining. J Cell Sci. 2021;134: pubmed publisher |
| Montales K, Kim A, Ruis K, Michael W. Structure-function analysis of TOPBP1's role in ATR signaling using the DSB-mediated ATR activation in Xenopus egg extracts (DMAX) system. Sci Rep. 2021;11:467 pubmed publisher |
| Ishimoto R, Tsuzuki Y, Matsumura T, Kurashige S, Enokitani K, Narimatsu K, et al. SLX4-XPF mediates DNA damage responses to replication stress induced by DNA-protein interactions. J Cell Biol. 2021;220: pubmed publisher |
| Pan Y, Wu C, Yeh C. ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner. Biomolecules. 2020;10: pubmed publisher |
| Deville S, Luft S, Kaufmann M, Cordes N. Keap1 inhibition sensitizes head and neck squamous cell carcinoma cells to ionizing radiation via impaired non-homologous end joining and induced autophagy. Cell Death Dis. 2020;11:887 pubmed publisher |
| Zhai B, Li Y, Kotapalli S, Bacha J, Brown D, Steinø A, et al. Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells. Cell Death Dis. 2020;11:577 pubmed publisher |
| Zhu C, Rogers A, Asleh K, Won J, Gao D, Leung S, et al. Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer. Cell Rep. 2020;31:107745 pubmed publisher |
| Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, et al. ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. Aging (Albany NY). 2020;12:4688-4710 pubmed publisher |
| Shu J, Cui D, Ma Y, Xiong X, Sun Y, Zhao Y. SCFβ-TrCP-mediated degradation of TOP2β promotes cancer cell survival in response to chemotherapeutic drugs targeting topoisomerase II. Oncogenesis. 2020;9:8 pubmed publisher |
| Valdez B, Li Y, Murray D, Liu Y, Nieto Y, Bashir Q, et al. Panobinostat and venetoclax enhance the cytotoxicity of gemcitabine, busulfan, and melphalan in multiple myeloma cells. Exp Hematol. 2020;81:32-41 pubmed publisher |
| Cui D, Xiong X, Shu J, Dai X, Sun Y, Zhao Y. FBXW7 Confers Radiation Survival by Targeting p53 for Degradation. Cell Rep. 2020;30:497-509.e4 pubmed publisher |
| Hayashi K, Hishikawa A, Hashiguchi A, Azegami T, Yoshimoto N, Nakamichi R, et al. Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy. Sci Rep. 2020;10:237 pubmed publisher |
| Crochemore C, Fernandez Molina C, Montagne B, Salles A, Ricchetti M. CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence. Nat Commun. 2019;10:5576 pubmed publisher |
| Jin S, Cordes N. ATM controls DNA repair and mitochondria transfer between neighboring cells. Cell Commun Signal. 2019;17:144 pubmed publisher |
| Choi C, Son A, Lee G, Shin S, Park S, Ahn S, et al. Targeting DNA-dependent protein kinase sensitizes hepatocellular carcinoma cells to proton beam irradiation through apoptosis induction. PLoS ONE. 2019;14:e0218049 pubmed publisher |
| Johnson D, Spitz Becker G, Chakraborti K, Bhaskara S. Assessment of epigenetic mechanisms and DNA double-strand break repair using laser micro-irradiation technique developed for hematological cells. EBioMedicine. 2019;43:138-149 pubmed publisher |
| Kreis P, Gallrein C, Rojas Puente E, Mack T, Kroon C, Dinkel V, et al. ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans. Nat Commun. 2019;10:486 pubmed publisher |
| Li C, Mahon C, Sweeney N, Verschueren E, Kantamani V, Li D, et al. PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis. Cell Rep. 2019;26:1333-1343.e7 pubmed publisher |
| Carranza D, Torres Rusillo S, Ceballos Pérez G, Blanco Jimenez E, Muñoz Lopez M, Garcia Perez J, et al. Reconstitution of the Ataxia-Telangiectasia Cellular Phenotype With Lentiviral Vectors. Front Immunol. 2018;9:2703 pubmed publisher |
| Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, et al. Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells. Sci Rep. 2018;8:14827 pubmed publisher |
| Zhai B, Steinø A, Bacha J, Brown D, Daugaard M. Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination. Cell Death Dis. 2018;9:1016 pubmed publisher |
| Valdez B, Tang X, Li Y, Murray D, Liu Y, Popat U, et al. Epigenetic modification enhances the cytotoxicity of busulfan and4-hydroperoxycyclophosphamide in AML cells. Exp Hematol. 2018;67:49-59.e1 pubmed publisher |
| Evangelista F, Maglott Roth A, Stierlé M, Brino L, Soutoglou E, Tora L. Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair. J Cell Biol. 2018;217:3382-3397 pubmed publisher |
| Sun J, Shi L, Kinomura A, Fukuto A, Horikoshi Y, Oma Y, et al. Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations. elife. 2018;7: pubmed publisher |
| Parisotto M, Grelet E, El Bizri R, Dai Y, Terzic J, Eckert D, et al. PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo. J Exp Med. 2018;215:1749-1763 pubmed publisher |
| Gu X, Qi Y, Feng Z, Ma L, Gao K, Zhang Y. Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway. Toxicol Lett. 2018;291:92-100 pubmed publisher |
| Gupta R, Somyajit K, Narita T, Maskey E, Stanlie A, Kremer M, et al. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Cell. 2018;173:972-988.e23 pubmed publisher |
| Vadnais C, Chen R, Fraszczak J, Yu Z, Boulais J, Pinder J, et al. GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1. Nat Commun. 2018;9:1418 pubmed publisher |
| Göder A, Emmerich C, Nikolova T, Kiweler N, Schreiber M, Kühl T, et al. HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130. Nat Commun. 2018;9:764 pubmed publisher |
| Chen L, Chen J, Huang Y, Gu Y, Qiu J, Qian H, et al. The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations. Mol Cell. 2018;69:412-425.e6 pubmed publisher |
| Michelini F, Pitchiaya S, Vitelli V, Sharma S, Gioia U, Pessina F, et al. Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks. Nat Cell Biol. 2017;19:1400-1411 pubmed publisher |
| Chen Z, Cao Z, Zhang W, Gu M, Zhou Z, Li B, et al. LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress. Hum Mol Genet. 2017;26:4494-4505 pubmed publisher |
| Feng W, Jasin M. BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination. Nat Commun. 2017;8:525 pubmed publisher |
| Gursoy Yuzugullu O, Carman C, Serafim R, Myronakis M, Valente V, Price B. Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity. Oncotarget. 2017;8:24518-24532 pubmed publisher |
| Higo T, Naito A, Sumida T, Shibamoto M, Okada K, Nomura S, et al. DNA single-strand break-induced DNA damage response causes heart failure. Nat Commun. 2017;8:15104 pubmed publisher |
| Valdez B, Li Y, Murray D, Liu Y, Nieto Y, Champlin R, et al. The PARP inhibitor olaparib enhances the cytotoxicity of combined gemcitabine, busulfan and melphalan in lymphoma cells. Leuk Lymphoma. 2017;58:2705-2716 pubmed publisher |
| Ashraf R, Hamidullah -, Hasanain M, Pandey P, Maheshwari M, Singh L, et al. Coumarin-chalcone hybrid instigates DNA damage by minor groove binding and stabilizes p53 through post translational modifications. Sci Rep. 2017;7:45287 pubmed publisher |
| Zheng M, Zhu Z, Zhao Y, Yao D, Wu M, Sun G. Oridonin promotes G2/M arrest in A549 cells by facilitating ATM activation. Mol Med Rep. 2017;15:375-379 pubmed publisher |
| Inoue S, Li W, Tseng A, Beerman I, Elia A, Bendall S, et al. Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2. Cancer Cell. 2016;30:337-348 pubmed publisher |
| Stankovic Valentin N, Drzewicka K, König C, Schiebel E, Melchior F. Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress. EMBO J. 2016;35:1312-29 pubmed publisher |
| Dubois E, Gerber S, KISSELEV A, Harel Bellan A, Groisman R. UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis. Oncol Rep. 2016;35:3101-5 pubmed publisher |
| Sifford J, Stahl J, Salinas E, Forrest J. Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication. J Virol. 2015;90:2571-85 pubmed publisher |
| Wang ondu R, Teal S, Park R, Heston L, Delecluse H, Miller G. DNA Damage Signaling Is Induced in the Absence of Epstein-Barr Virus (EBV) Lytic DNA Replication and in Response to Expression of ZEBRA. PLoS ONE. 2015;10:e0126088 pubmed publisher |
| Modzelewski A, Hilz S, Crate E, Schweidenback C, Fogarty E, Grenier J, et al. Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males. J Cell Sci. 2015;128:2314-27 pubmed publisher |
| Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, et al. Notch is a direct negative regulator of the DNA-damage response. Nat Struct Mol Biol. 2015;22:417-24 pubmed publisher |
| Huskey N, Guo T, Evason K, Momcilovic O, Pardo D, Creasman K, et al. CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation. Stem Cell Reports. 2015;4:374-89 pubmed publisher |
| Valdez B, Li Y, Murray D, Ji J, Liu Y, Popat U, et al. Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators. Exp Hematol. 2015;43:448-61.e2 pubmed publisher |
| Fumagalli M, Rossiello F, Mondello C, d Adda di Fagagna F. Stable cellular senescence is associated with persistent DDR activation. PLoS ONE. 2014;9:e110969 pubmed publisher |
| Broering T, Alavattam K, Sadreyev R, Ichijima Y, Kato Y, Hasegawa K, et al. BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis. J Cell Biol. 2014;205:663-75 pubmed publisher |
| Carvalho S, Vítor A, Sridhara S, Martins F, Raposo A, Desterro J, et al. SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint. elife. 2014;3:e02482 pubmed publisher |
| Mikawa T, Maruyama T, Okamoto K, Nakagama H, Lleonart M, Tsusaka T, et al. Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2. J Cell Biol. 2014;204:729-45 pubmed publisher |
| Min W, Bruhn C, Grigaravicius P, Zhou Z, Li F, Krüger A, et al. Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation. Nat Commun. 2013;4:2993 pubmed publisher |
| Toledo L, Altmeyer M, Rask M, Lukas C, Larsen D, Povlsen L, et al. ATR prohibits replication catastrophe by preventing global exhaustion of RPA. Cell. 2013;155:1088-103 pubmed publisher |
| Lim H, Xie L, Zhang W, Li R, Chen Z, Wu G, et al. Ribosomal S6 Kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway. PLoS ONE. 2013;8:e74334 pubmed publisher |
| Vidal Eychenié S, Décaillet C, Basbous J, Constantinou A. DNA structure-specific priming of ATR activation by DNA-PKcs. J Cell Biol. 2013;202:421-9 pubmed publisher |
| Cesare A, Hayashi M, Crabbe L, Karlseder J. The telomere deprotection response is functionally distinct from the genomic DNA damage response. Mol Cell. 2013;51:141-55 pubmed publisher |
| Floyd S, Pacold M, Huang Q, Clarke S, Lam F, Cannell I, et al. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 2013;498:246-50 pubmed publisher |
| Rodriguez Hernandez C, Llorens Agost M, Calbo J, Murguia J, Guinovart J. Sodium tungstate modulates ATM function upon DNA damage. FEBS Lett. 2013;587:1579-86 pubmed publisher |
| Castro Vega L, Jouravleva K, Liu W, Martinez C, Gestraud P, Hupe P, et al. Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas. Carcinogenesis. 2013;34:1173-80 pubmed publisher |
| Osorio F, Bárcena C, Soria Valles C, Ramsay A, de Carlos F, Cobo J, et al. Nuclear lamina defects cause ATM-dependent NF-?B activation and link accelerated aging to a systemic inflammatory response. Genes Dev. 2012;26:2311-24 pubmed publisher |
| Javvadi P, Makino H, Das A, Lin Y, Chen D, Chen B, et al. Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance. Mol Cancer Res. 2012;10:1359-68 pubmed publisher |
| Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, et al. TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Cell. 2012;150:697-709 pubmed publisher |
| Daugaard M, Baude A, Fugger K, Povlsen L, Beck H, Sørensen C, et al. LEDGF (p75) promotes DNA-end resection and homologous recombination. Nat Struct Mol Biol. 2012;19:803-10 pubmed publisher |
| Daugherity E, Balmus G, Al Saei A, Moore E, Abi Abdallah D, Rogers A, et al. The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease. Cell Cycle. 2012;11:1918-28 pubmed publisher |
| Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov J, et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol. 2012;14:355-65 pubmed publisher |
| Hayashi M, Cesare A, Fitzpatrick J, Lazzerini Denchi E, Karlseder J. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. Nat Struct Mol Biol. 2012;19:387-94 pubmed publisher |
| Vadnais C, Davoudi S, Afshin M, Harada R, Dudley R, Clermont P, et al. CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage. Nucleic Acids Res. 2012;40:4483-95 pubmed publisher |
| Jurado S, Conlan L, Baker E, Ng J, Tenis N, Hoch N, et al. ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression. J Biol Chem. 2012;287:3156-64 pubmed publisher |
| Vogel R, Seyffert M, Strasser R, de Oliveira A, Dresch C, Glauser D, et al. Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection. J Virol. 2012;86:143-55 pubmed publisher |
| Sugimoto N, Yugawa T, Iizuka M, Kiyono T, Fujita M. Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation. J Biol Chem. 2011;286:39200-10 pubmed publisher |
| Zhang W, Peng G, Lin S, Zhang P. DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells. J Biol Chem. 2011;286:35899-905 pubmed publisher |
| Fradet Turcotte A, Bergeron Labrecque F, Moody C, Lehoux M, Laimins L, Archambault J. Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response. J Virol. 2011;85:8996-9012 pubmed publisher |
| Ling S, Lin W. EDD inhibits ATM-mediated phosphorylation of p53. J Biol Chem. 2011;286:14972-82 pubmed publisher |
| Al Rashid S, Harding S, Law C, Coackley C, Bristow R. Protein-protein interactions occur between p53 phosphoforms and ATM and 53BP1 at sites of exogenous DNA damage. Radiat Res. 2011;175:588-98 pubmed publisher |
| Suzuki K, Yamauchi M, Oka Y, Suzuki M, Yamashita S. Creating localized DNA double-strand breaks with microirradiation. Nat Protoc. 2011;6:134-9 pubmed publisher |
| Jurado S, Smyth I, van Denderen B, Tenis N, Hammet A, Hewitt K, et al. Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis. PLoS Genet. 2010;6:e1001170 pubmed publisher |
| Adeyemi R, Landry S, Davis M, Weitzman M, Pintel D. Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication. PLoS Pathog. 2010;6:e1001141 pubmed publisher |
| Hurov K, Cotta Ramusino C, Elledge S. A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev. 2010;24:1939-50 pubmed publisher |
| Larsen D, Poinsignon C, Gudjonsson T, Dinant C, Payne M, Hari F, et al. The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J Cell Biol. 2010;190:731-40 pubmed publisher |
| Sato K, Nishikino M, Okano Y, Ohshima S, Hasegawa N, Ishino M, et al. ?-H2AX and phosphorylated ATM focus formation in cancer cells after laser plasma X irradiation. Radiat Res. 2010;174:436-45 pubmed publisher |
| Jun J, Lau L. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol. 2010;12:676-85 pubmed publisher |
| Boichuk S, Hu L, Hein J, Gjoerup O. Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen. J Virol. 2010;84:8007-20 pubmed publisher |
| Alimonti A, Nardella C, Chen Z, Clohessy J, Carracedo A, Trotman L, et al. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest. 2010;120:681-93 pubmed publisher |
| Collaco R, Bevington J, Bhrigu V, Kalman Maltese V, Trempe J. Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways. Virology. 2009;392:24-33 pubmed publisher |
| Efeyan A, Murga M, Martinez Pastor B, Ortega Molina A, Soria R, Collado M, et al. Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression. PLoS ONE. 2009;4:e5475 pubmed publisher |
| Sugimoto N, Yoshida K, Tatsumi Y, Yugawa T, Narisawa Saito M, Waga S, et al. Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells. J Cell Sci. 2009;122:1184-91 pubmed publisher |
| Acosta J, O Loghlen A, Banito A, Guijarro M, Augert A, Raguz S, et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell. 2008;133:1006-18 pubmed publisher |
| Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa Saito M, et al. Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1. Mol Biol Cell. 2008;19:1007-21 pubmed |
| Gorrini C, Squatrito M, Luise C, Syed N, Perna D, Wark L, et al. Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. Nature. 2007;448:1063-7 pubmed |
| Jacquemont C, Taniguchi T. Proteasome function is required for DNA damage response and fanconi anemia pathway activation. Cancer Res. 2007;67:7395-405 pubmed |
| Ramirez T, Stopper H, Hock R, Herrera L. Prevention of aneuploidy by S-adenosyl-methionine in human cells treated with sodium arsenite. Mutat Res. 2007;617:16-22 pubmed |
| Bartkova J, Bakkenist C, Rajpert De Meyts E, Skakkebaek N, Sehested M, Lukas J, et al. ATM activation in normal human tissues and testicular cancer. Cell Cycle. 2005;4:838-45 pubmed |
| Bartkova J, Horejsi Z, Koed K, Krämer A, Tort F, Zieger K, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature. 2005;434:864-70 pubmed |
| Warters R, Adamson P, Pond C, Leachman S. Melanoma cells express elevated levels of phosphorylated histone H2AX foci. J Invest Dermatol. 2005;124:807-17 pubmed |
| Falck J, Coates J, Jackson S. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature. 2005;434:605-11 pubmed |
| Kitagawa R, Bakkenist C, McKinnon P, Kastan M. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 2004;18:1423-38 pubmed |
| Powers J, Hong S, Mayhew C, Rogers P, Knudsen E, Johnson D. E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis. Mol Cancer Res. 2004;2:203-14 pubmed |
| Bakkenist C, Kastan M. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 2003;421:499-506 pubmed |
