Cox-2 Antibody | Rockland Immunochemicals 100-401-226 product information

product summary

company name :

Rockland Immunochemicals

product type :

antibody

product name :

Cox-2 Antibody

catalog :

100-401-226

quantity :

100 µL

price :

369.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry

more info or order :

Rockland Immunochemicals product webpage

product information

Catalog Number :

100-401-226

Name :

Anti-COX-2 (RABBIT) Antibody - 100-401-226

Display Name :

Cox-2 Antibody

Application Note :

Cox-2 (Cyclooxygenase-2) is an inducible enzyme that is normally absent from cells, however, in response to growth factors, tumor promoters and some cytokines, it undergoes a rapid and transient expression. This antiserum against Human Cox-2 and has been tested for use in immunoblotting and ELISA. The antibody recognizes Cox-2 at 70kDa in Sf9 cell lines transfected with Cox-2 as well as in WISH cells induced with IL-1b. Reactivity in other immunoassays is unknown.

Clonality :

Polyclonal

Concentration Value :

55 mg/mL

Concentration Definition :

by Refractometry

Conjugation :

(None)

Size :

100 µL

Default Unit :

ELISA Dilution :

1:10,000 - 1:50,000

Immunohistochemistry Dilution :

User Optimized

Western Blot Dilution :

1:5,000 - 1:10,000

Expiration :

Expiration date is one (1) year from date of opening.

Format :

Antiserum

Gene Name :

PTGS2

Host Animal :

Rabbit

General Disclaimer Note :

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Immunogen :

This whole rabbit serum was prepared by repeated immunizations with a fusion protein corresponding to the carboxy-terminus of human Cox-2.

Packing Type :

Dry Ice

Physical State :

Liquid (sterile filtered)

Preservative :

0.01% (w/v) Sodium Azide

Purity and Specificity :

This antiserum is directed against human Cox-2. Two different isoforms of the enzyme are known, Cox-1 and Cox-2. A BLAST analysis was used to suggest cross-reactivity with Cox-2 in human, mouse and rat based on a homology with the immunizing sequence and should not cross react with Cox-1. Reactivity against homologues from other sources is not known. Reactivity of this antibody with Cox-2 from other species is unknown.

Species Reactivity :

human, mouse, rat

Storage :

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Synonyms :

rabbit anti-COX2 antibody, Prostaglandin G/H synthase 2 antibody, Cyclooxygenase-2 antibody, Prostaglandin-endoperoxide synthase 2 antibody, Prostaglandin H2 synthase 2 antibody, PGH synthase 2 antibody, PGHS-2 antibody

Target Species :

Human

Background :

COX-2, also known as prostaglandin H synthase, was identified less than a decade ago. Its discovery was followed by a period of discovery and drug development to create a “super aspirin” and led to insights into arthritis, Alzheimer's disease, colorectal cancer and regulation of brain and kidney function in search of better treatments for degenerative and inflammatory diseases. Cox-2 is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, Cox-2 is therefore of interest in studying immune response regulation.

Immunogen Type :

Recombinant Protein

Low Endotoxin :

Sample Size :

Target Domain of Reactivity :

C-Terminus

Application Text :

ELISA,Immunohistochemistry,Western Blot,

Other :

User Optimized

Category :

Primary Antibodies

Conjugation Name :

Unconjugated

2020 Price :

369.00 USD

UniProt :

P35354

NCBI :

P35354.2

Primary Image Name :

Anti-Cox2 Antibody - Western Blot

more info or order :

Rockland Immunochemicals product webpage