product summary
Loading...
company name :
Reliatech GmbH
product type :
antibody
product name :
Prox-1
catalog :
102-PA32S
quantity :
100
price :
175 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
Rabbit IG
reactivity :
human
application :
western blot, immunocytochemistry
more info or order :
citations: 80
Reference
Kawai Y, Kaidoh M, Yokoyama Y, Sano K, Ohhashi T. Chemokine CCL2 facilitates ICAM-1-mediated interactions of cancer cells and lymphatic endothelial cells in sentinel lymph nodes. Cancer Sci. 2009;100:419-28 pubmed publisher
Hirakawa S, Detmar M, Kerjaschki D, Nagamatsu S, Matsuo K, Tanemura A, et al. Nodal lymphangiogenesis and metastasis: Role of tumor-induced lymphatic vessel activation in extramammary Paget's disease. Am J Pathol. 2009;175:2235-48 pubmed publisher
Kim K, Koh Y, Jeon B, Jang C, Han J, Kataru R, et al. Role of CD11b+ macrophages in intraperitoneal lipopolysaccharide-induced aberrant lymphangiogenesis and lymphatic function in the diaphragm. Am J Pathol. 2009;175:1733-45 pubmed publisher
Rubin A, Kessaris N. PROX1: a lineage tracer for cortical interneurons originating in the lateral/caudal ganglionic eminence and preoptic area. PLoS ONE. 2013;8:e77339 pubmed publisher
Kang J, Yoo J, Lee S, Tang W, Aguilar B, Ramu S, et al. An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. Blood. 2010;116:140-50 pubmed publisher
Brennan C, Mangoli M, Dyer C, Ashworth R. Acetylcholine and calcium signalling regulates muscle fibre formation in the zebrafish embryo. J Cell Sci. 2005;118:5181-90 pubmed
Nörder M, Gutierrez M, Zicari S, Cervi E, Caruso A, Guzman C. Lymph node-derived lymphatic endothelial cells express functional costimulatory molecules and impair dendritic cell-induced allogenic T-cell proliferation. FASEB J. 2012;26:2835-46 pubmed publisher
Buttler K, Kreysing A, Von Kaisenberg C, Schweigerer L, Gale N, Papoutsi M, et al. Mesenchymal cells with leukocyte and lymphendothelial characteristics in murine embryos. Dev Dyn. 2006;235:1554-62 pubmed
Choi I, Chung H, Ramu S, Lee H, Kim K, Lee S, et al. Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse. Blood. 2011;117:362-5 pubmed publisher
Sleeckx N, Van Brantegem L, Van den Eynden G, Fransen E, Casteleyn C, Van Cruchten S, et al. Lymphangiogenesis in canine mammary tumours: a morphometric and prognostic study. J Comp Pathol. 2014;150:184-93 pubmed publisher
Requena L, El-Shabrawi-Caelen L, Walsh S, Segura S, Ziemer M, Hurt M, et al. Intralymphatic histiocytosis. A clinicopathologic study of 16 cases. Am J Dermatopathol. 2009;31:140-51 pubmed publisher
Risebro C, Searles R, Melville A, Ehler E, Jina N, Shah S, et al. Prox1 maintains muscle structure and growth in the developing heart. Development. 2009;136:495-505 pubmed publisher
Kholova I, Dragneva G, Cermáková P, Laidinen S, Kaskenpää N, Hazes T, et al. Lymphatic vasculature is increased in heart valves, ischaemic and inflamed hearts and in cholesterol-rich and calcified atherosclerotic lesions. Eur J Clin Invest. 2011;41:487-97 pubmed publisher
Benevenuto de Andrade B, Ramírez-Amador V, Anaya-Saavedra G, Martínez-Mata G, Fonseca F, Graner E, et al. Expression of PROX-1 in oral Kaposi's sarcoma spindle cells. J Oral Pathol Med. 2014;43:132-6 pubmed publisher
Jang C, Koh Y, Lim N, Kang H, Kim D, Park S, et al. Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells. Arterioscler Thromb Vasc Biol. 2009;29:401-7 pubmed publisher
Ushijima N, Inoue K, Domon T, Yoshida S. Distribution and organization of lymphatic vessels in the mouse gingiva: An immunohistochemical study with LYVE-1. Arch Oral Biol. 2008;53:652-8 pubmed publisher
Yoon C, Hong B, Moon H, Lim S, Suh P, Kim Y, et al. Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways. Blood. 2008;112:1129-38 pubmed publisher
Keenan I, Rhee H, Chaudhry B, Henderson D. Origin of non-cardiac endothelial cells from an Isl1+ lineage. FEBS Lett. 2012;586:1790-4 pubmed publisher
Laerm A, Helmbold P, Goldberg M, Dammann R, Holzhausen H, Ballhausen W. Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system. J Hepatol. 2007;46:89-97 pubmed
de Mooij Y, Van Den Akker N, Bekker M, Bartelings M, Wisse L, van Vugt J, et al. Abnormal Shh and FOXC2 expression correlates with aberrant lymphatic development in human fetuses with increased nuchal translucency. Prenat Diagn. 2009;29:840-6 pubmed publisher
Akhmetshina A, Beer J, Zwerina K, Englbrecht M, Palumbo K, Dees C, et al. Decreased lymphatic vessel counts in patients with systemic sclerosis: association with fingertip ulcers. Arthritis Rheum. 2010;62:1513-22 pubmed publisher
Dolez M, Nicolas J, Hirsinger E. Laminins, via heparan sulfate proteoglycans, participate in zebrafish myotome morphogenesis by modulating the pattern of Bmp responsiveness. Development. 2011;138:97-106 pubmed publisher
Bekker M, Van Den Akker N, Bartelings M, Arkesteijn J, Fischer S, Polman J, et al. Nuchal edema and venous-lymphatic phenotype disturbance in human fetuses and mouse embryos with aneuploidy. J Soc Gynecol Investig. 2006;13:209-16 pubmed
Kawai Y, Minami T, Fujimori M, Hosaka K, Mizuno R, Ikomi F, et al. Characterization and microarray analysis of genes in human lymphatic endothelial cells from patients with breast cancer. Lymphat Res Biol. 2007;5:115-26 pubmed
Becker J, Fröhlich J, Perske C, Pavlakovic H, Wilting J. Reelin signalling in neuroblastoma: migratory switch in metastatic stages. Int J Oncol. 2012;41:681-9 pubmed publisher
Kilic N, Oliveira-Ferrer L, Neshat-Vahid S, Irmak S, Obst-Pernberg K, Wurmbach J, et al. Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1. Blood. 2007;110:4223-33 pubmed
Buttler K, Becker J, Pukrop T, Wilting J. Maldevelopment of dermal lymphatics in Wnt5a-knockout-mice. Dev Biol. 2013;381:365-76 pubmed publisher
Vondenhoff M, van de Pavert S, Dillard M, Greuter M, Goverse G, Oliver G, et al. Lymph sacs are not required for the initiation of lymph node formation. Development. 2009;136:29-34 pubmed publisher
von Kaisenberg C, Wilting J, Dork T, Nicolaides K, Meinhold-Heerlein I, Hillemanns P, et al. Lymphatic capillary hypoplasia in the skin of fetuses with increased nuchal translucency and Turner's syndrome: comparison with trisomies and controls. Mol Hum Reprod. 2010;16:778-89 pubmed publisher
Junginger J, Rötting A, Staszyk C, Kramer K, Hewicker-Trautwein M. Identification of equine cutaneous lymphangioma by application of a lymphatic endothelial cell marker. J Comp Pathol. 2010;143:57-60 pubmed publisher
Pedrioli D, Karpanen T, Dabouras V, Jurisic G, van de Hoek G, Shin J, et al. miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo. Mol Cell Biol. 2010;30:3620-34 pubmed publisher
Nguyen V, Fürhapter C, Obexer P, Stössel H, Romani N, Sepp N. Endothelial cells from cord blood CD133+CD34+ progenitors share phenotypic, functional and gene expression profile similarities with lymphatics. J Cell Mol Med. 2009;13:522-34 pubmed publisher
Takahashi M, Yoshimoto T, Shimoda M, Kono T, Koizumi M, Yazumi S, et al. Loss of function of the candidate tumor suppressor prox1 by RNA mutation in human cancer cells. Neoplasia. 2006;8:1003-10 pubmed
Spinella F, Garrafa E, Di Castro V, Rosanò L, Nicotra M, Caruso A, et al. Endothelin-1 stimulates lymphatic endothelial cells and lymphatic vessels to grow and invade. Cancer Res. 2009;69:2669-76 pubmed publisher
Sleeckx N, Van Brantegem L, Fransen E, Van den Eynden G, Casteleyn C, Veldhuis Kroeze E, et al. Evaluation of immunohistochemical markers of lymphatic and blood vessels in canine mammary tumours. J Comp Pathol. 2013;148:307-17 pubmed publisher
Lachance P, Hazen A, Sevick-Muraca E. Lymphatic vascular response to acute inflammation. PLoS ONE. 2013;8:e76078 pubmed publisher
Kono T, Kubo H, Shimazu C, Ueda Y, Takahashi M, Yanagi K, et al. Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells. Arterioscler Thromb Vasc Biol. 2006;26:2070-6 pubmed
Kasten P, Schnöink G, Bergmann A, Papoutsi M, Buttler K, Rossler J, et al. Similarities and differences of human and experimental mouse lymphangiomas. Dev Dyn. 2007;236:2952-61 pubmed
László V, Dezso K, Baghy K, Papp V, Kovalszky I, Safrany G, et al. Triiodothyronine accelerates differentiation of rat liver progenitor cells into hepatocytes. Histochem Cell Biol. 2008;130:1005-14 pubmed publisher
Gonzalez-Nunez V, Nocco V, Budd A. Characterization of drCol 15a1b: a novel component of the stem cell niche in the zebrafish retina. Stem Cells. 2010;28:1399-411 pubmed publisher
Requena L, Santonja C, Stutz N, Kaddu S, Weenig R, Kutzner H, et al. Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma. Am J Dermatopathol. 2007;29:342-50 pubmed
Martin A, Gasse H, Staszyk C. Absence of lymphatic vessels in the dog dental pulp: an immunohistochemical study. J Anat. 2010;217:609-15 pubmed publisher
Bekker M, Van Den Akker N, de Mooij Y, Bartelings M, van Vugt J, Gittenberger-de Groot A. Jugular lymphatic maldevelopment in Turner syndrome and trisomy 21: different anomalies leading to nuchal edema. Reprod Sci. 2008;15:295-304 pubmed publisher
Garrafa E, Alessandri G, Benetti A, Turetta D, Corradi A, Cantoni A, et al. Isolation and characterization of lymphatic microvascular endothelial cells from human tonsils. J Cell Physiol. 2006;207:107-13 pubmed
Buttler K, Ezaki T, Wilting J. Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics. BMC Dev Biol. 2008;8:43 pubmed publisher
Shields J, Fleury M, Yong C, Tomei A, Randolph G, Swartz M. Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling. Cancer Cell. 2007;11:526-38 pubmed
Akagami M, Kawada K, Kubo H, Kawada M, Takahashi M, Kaganoi J, et al. Transcriptional factor Prox1 plays an essential role in the antiproliferative action of interferon-γ in esophageal cancer cells. Ann Surg Oncol. 2011;18:3868-77 pubmed publisher
Kim M, Koh Y, Kim K, Koh B, Nam D, Alitalo K, et al. CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche. Cancer Res. 2010;70:10411-21 pubmed publisher
Aguilar B, Choi I, Choi D, Chung H, Lee S, Yoo J, et al. Lymphatic reprogramming by Kaposi sarcoma herpes virus promotes the oncogenic activity of the virus-encoded G-protein-coupled receptor. Cancer Res. 2012;72:5833-42 pubmed publisher
Laco F, Grant M, Black R. Collagen-nanofiber hydrogel composites promote contact guidance of human lymphatic microvascular endothelial cells and directed capillary tube formation. J Biomed Mater Res A. 2013;101:1787-99 pubmed publisher
Quagliata L, Klusmeier S, Cremers N, Pytowski B, Harvey A, Pettis R, et al. Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model. Clin Exp Metastasis. 2014;31:351-65 pubmed publisher
Van der Auwera I, Van den Eynden G, Colpaert C, Van Laere S, Van Dam P, Van Marck E, et al. Tumor lymphangiogenesis in inflammatory breast carcinoma: a histomorphometric study. Clin Cancer Res. 2005;11:7637-42 pubmed
Buttler K, Badar M, Seiffart V, Laggies S, Gross G, Wilting J, et al. De novo hem- and lymphangiogenesis by endothelial progenitor and mesenchymal stem cells in immunocompetent mice. Cell Mol Life Sci. 2014;71:1513-27 pubmed publisher
Rompani S, Cepko C. Retinal progenitor cells can produce restricted subsets of horizontal cells. Proc Natl Acad Sci U S A. 2008;105:192-7 pubmed
Schneider M, Buchler P, Giese N, Giese T, Wilting J, Buchler M, et al. Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread. Int J Oncol. 2006;28:883-90 pubmed
Misra K, Mishra K, Gui H, Matise M. Prox1 regulates a transitory state for interneuron neurogenesis in the spinal cord. Dev Dyn. 2008;237:393-402 pubmed publisher
Ji R, Eshita Y, Xing L, Miura M. Multiple expressions of lymphatic markers and morphological evolution of newly formed lymphatics in lymphangioma and lymph node lymphangiogenesis. Microvasc Res. 2010;80:195-201 pubmed publisher
Lobbardi R, Lambert G, Zhao J, Geisler R, Kim H, Rosa F. Fine-tuning of Hh signaling by the RNA-binding protein Quaking to control muscle development. Development. 2011;138:1783-94 pubmed publisher
Dudas J, Elmaouhoub A, Mansuroglu T, Batusic D, Tron K, Saile B, et al. Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from "oval cells". Histochem Cell Biol. 2006;126:549-62 pubmed
Nisato R, Buser R, Pepper M. Lymphatic endothelial cells: establishment of primaries and characterization of established lines. Methods Mol Biol. 2009;467:113-26 pubmed
Dudas J, Mansuroglu T, Moriconi F, Haller F, Wilting J, Lorf T, et al. Altered regulation of Prox1-gene-expression in liver tumors. BMC Cancer. 2008;8:92 pubmed publisher
Van den Eynden G, Van der Auwera I, Van Laere S, Huygelen V, Colpaert C, van Dam P, et al. Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer. Br J Cancer. 2006;95:1362-6 pubmed
Welham S, Riley P, Wade A, Hubank M, Woolf A. Maternal diet programs embryonic kidney gene expression. Physiol Genomics. 2005;22:48-56 pubmed
de Mooij Y, Van Den Akker N, Bekker M, Bartelings M, van Vugt J, Gittenberger-de Groot A. Aberrant lymphatic development in euploid fetuses with increased nuchal translucency including Noonan syndrome. Prenat Diagn. 2011;31:159-66 pubmed publisher
Elkouris M, Balaskas N, Poulou M, Politis P, Panayiotou E, Malas S, et al. Sox1 maintains the undifferentiated state of cortical neural progenitor cells via the suppression of Prox1-mediated cell cycle exit and neurogenesis. Stem Cells. 2011;29:89-98 pubmed publisher
Sotiropoulou N, Bravou V, Kounelis S, Damaskou V, Papaspirou E, Papadaki H. Tumour expression of lymphangiogenic growth factors but not lymphatic vessel density is implicated in human cervical cancer progression. Pathology. 2010;42:629-36 pubmed publisher
Kawai Y, Hosaka K, Kaidoh M, Minami T, Kodama T, Ohhashi T. Heterogeneity in immunohistochemical, genomic, and biological properties of human lymphatic endothelial cells between initial and collecting lymph vessels. Lymphat Res Biol. 2008;6:15-27 pubmed publisher
Lee A, Lee J, Jung Y, Kim D, Kang K, Lee S, et al. Vascular endothelial growth factor-C and -D are involved in lymphangiogenesis in mouse unilateral ureteral obstruction. Kidney Int. 2013;83:50-62 pubmed publisher
Fiedler U, Christian S, Koidl S, Kerjaschki D, Emmett M, Bates D, et al. The sialomucin CD34 is a marker of lymphatic endothelial cells in human tumors. Am J Pathol. 2006;168:1045-53 pubmed
Hadamitzky C, Blum K, Pabst R. Regeneration of autotransplanted avascular lymph nodes in the rat is improved by platelet-rich plasma. J Vasc Res. 2009;46:389-96 pubmed publisher
Hasenpusch-Theil K, Magnani D, Amaniti E, Han L, Armstrong D, Theil T. Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus. Cereb Cortex. 2012;22:2878-93 pubmed publisher
Becker J, Wang B, Pavlakovic H, Buttler K, Wilting J. Homeobox transcription factor Prox1 in sympathetic ganglia of vertebrate embryos: correlation with human stage 4s neuroblastoma. Pediatr Res. 2010;68:112-7 pubmed publisher
Schledzewski K, Falkowski M, Moldenhauer G, Metharom P, Kzhyshkowska J, Ganss R, et al. Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogene. J Pathol. 2006;209:67-77 pubmed
Shimoda M, Takahashi M, Yoshimoto T, Kono T, Ikai I, Kubo H. A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma. Clin Cancer Res. 2006;12:6005-11 pubmed
Nisato R, Harrison J, Buser R, Orci L, Rinsch C, Montesano R, et al. Generation and characterization of telomerase-transfected human lymphatic endothelial cells with an extended life span. Am J Pathol. 2004;165:11-24 pubmed
Wang Y, Nakayama M, Pitulescu M, Schmidt T, Bochenek M, Sakakibara A, et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature. 2010;465:483-6 pubmed publisher
Lee A, Kim D, Lee J, Jung Y, Kang K, Lee S, et al. Erythropoietin induces lymph node lymphangiogenesis and lymph node tumor metastasis. Cancer Res. 2011;71:4506-17 pubmed publisher
Mentzel T, Schildhaus H, Palmedo G, Buttner R, Kutzner H. Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis o. Mod Pathol. 2012;25:75-85 pubmed publisher
Kim K, Sung H, Koh G. Lymphatic development in mouse small intestine. Dev Dyn. 2007;236:2020-5 pubmed
Foskolou I, Stellas D, Rozani I, Lavigne M, Politis P. Prox1 suppresses the proliferation of neuroblastoma cells via a dual action in p27-Kip1 and Cdc25A. Oncogene. 2013;32:947-60 pubmed publisher
product information
Product Name :
Prox-1
Reactivity :
Anti-Human
Clonality :
Polyclonal Antibody
Host Species :
Rabbit
Cat.-Number :
102-PA32S
SIZE [ug] :
100
Price [Euro] :
175 USD
Clone :
Rabbit IG
Application :
WB, IF
more info or order :
company information
Reliatech GmbH
Lindener Str. 15
38300 Wolfenbuettel
info@reliatech.de
www.reliatech.de
49 0 5331 8586 987
headquarters: Germany