Mouse Serpin A3N Antibody | R&D Systems AF4709 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse Serpin A3N Antibody

catalog :

AF4709

quantity :

100 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - free floating section

more info or order :

R&D Systems product webpage

citations: 26

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - free floating section; mouse; 1:100; loading ...; fig 2a	Kaya T, Mattugini N, Liu L, Ji H, Cantuti Castelvetri L, Wu J, et al. CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging. Nat Neurosci. 2022;25:1446-1457 pubmed publisher
	Mittra N, He S, Bao H, Bhattacharjee A, Dodds S, Dupree J, et al. Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of Trem2-mediated microglial activation. bioRxiv. 2024;: pubmed publisher
	Hou J, Zhou Y, Cai Z, Terekhova M, Swain A, Andhey P, et al. Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination. Cell Rep. 2023;42:112293 pubmed publisher
	Zhou Y, Tada M, Cai Z, Andhey P, Swain A, Miller K, et al. Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia. Nat Immunol. 2023;24:545-557 pubmed publisher
	Tran M, Mostofa G, Picard M, Wu J, Wang L, Shin D. SerpinA3N deficiency attenuates steatosis and enhances insulin signaling in male mice. J Endocrinol. 2023;256: pubmed publisher
	McNamara N, Munro D, Bestard Cuche N, Uyeda A, Bogie J, Hoffmann A, et al. Microglia regulate central nervous system myelin growth and integrity. Nature. 2023;613:120-129 pubmed publisher
	Wagner J, Degenhardt K, Veit M, Louros N, Konstantoulea K, Skodras A, et al. Medin co-aggregates with vascular amyloid-β in Alzheimer's disease. Nature. 2022;612:123-131 pubmed publisher
	Kenigsbuch M, Bost P, Halevi S, Chang Y, Chen S, Ma Q, et al. A shared disease-associated oligodendrocyte signature among multiple CNS pathologies. Nat Neurosci. 2022;25:876-886 pubmed publisher
	Saroja S, Sharma A, Hof P, Pereira A. Differential expression of tau species and the association with cognitive decline and synaptic loss in Alzheimer's disease. Alzheimers Dement. 2022;18:1602-1615 pubmed publisher
	Shen Y, Yang W, Xiong X, Li X, Xiao Z, Yu J, et al. Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage. Oxid Med Cell Longev. 2021;2021:2510847 pubmed publisher
	Qiu S, Palavicini J, Wang J, Gonzalez N, He S, Dustin E, et al. Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment. Mol Neurodegener. 2021;16:64 pubmed publisher
	Jiang H, Deng R, Deng Y, Nie M, Deng Y, Luo H, et al. The role of Serpina3n in the reversal effect of ATRA on dexamethasone-inhibited osteogenic differentiation in mesenchymal stem cells. Stem Cell Res Ther. 2021;12:291 pubmed publisher
	Ho Y, Shimbo T, Wijaya E, Kitayama T, Takaki S, Ikegami K, et al. Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model. Cell Mol Gastroenterol Hepatol. 2021;12:547-566 pubmed publisher
	Akbor M, Kurosawa N, Nakayama H, Nakatani A, Tomobe K, Chiba Y, et al. Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta. PLoS ONE. 2021;16:e0248027 pubmed publisher
	Heller G, Marshall M, Issa Y, Marshall J, Nguyen D, Rue E, et al. Waning efficacy in a long-term AAV-mediated gene therapy study in the murine model of Krabbe disease. Mol Ther. 2021;29:1883-1902 pubmed publisher
	. CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS. Neurol Neuroimmunol Neuroinflamm. 2021;8: pubmed publisher
	Staurenghi E, Cerrato V, Gamba P, Testa G, Giannelli S, Leoni V, et al. Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2. Redox Biol. 2021;39:101837 pubmed publisher
	Massart I, Paulissen G, Loumaye A, Lause P, Pötgens S, Thibaut M, et al. Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia. Cancers (Basel). 2020;12: pubmed publisher
	Hong S, Yang M, Cho H, Park I, Bae H, Choe K, et al. Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi. Nat Commun. 2020;11:4102 pubmed publisher
	Hulmi J, Penna F, P xf6 ll xe4 nen N, Nissinen T, Hentil xe4 J, Euro L, et al. Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia-the effects of blocking myostatin and activins. Mol Metab. 2020;41:101046 pubmed publisher
	Habib N, McCabe C, Medina S, Varshavsky M, Kitsberg D, Dvir Szternfeld R, et al. Disease-associated astrocytes in Alzheimer's disease and aging. Nat Neurosci. 2020;23:701-706 pubmed publisher
	Zhao N, Ren Y, Yamazaki Y, Qiao W, Li F, Felton L, et al. Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. Neuron. 2020;106:727-742.e6 pubmed publisher
	Lipski D, Foucart V, Dewispelaere R, Caspers L, Defrance M, Bruyns C, et al. Retinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach. BMC Ophthalmol. 2020;20:106 pubmed publisher
	Zhou Y, Song W, Andhey P, Swain A, Levy T, Miller K, et al. Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease. Nat Med. 2020;26:131-142 pubmed publisher
	Dalby M, Aviello G, Ross A, Walker A, Barrett P, Morgan P. Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N. Sci Rep. 2018;8:15648 pubmed publisher
	Vanni S, Moda F, Zattoni M, Bistaffa E, De Cecco E, Rossi M, et al. Differential overexpression of SERPINA3 in human prion diseases. Sci Rep. 2017;7:15637 pubmed publisher

product information

brand :

R&D Systems

master code :

AF4709

SKU :

AF4709

product name :

Mouse Serpin A3N Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Mouse Serpin A3N Antibody from R&D Systems is a goat polyclonal antibody to Serpin A3N. This antibody reacts with human,mouse,transgenic mouse. The Mouse Serpin A3N Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunoprecipitation,Immunofluorescence.

target :

Serpin A3N

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.1 ug/mL, Immunoprecipitation 25 ug/mL

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse Serpin A3N, Phe21-Lys418, Accession # Q91WP6

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Transgenic Mouse

specificity :

Detects mouse Serpin A3N in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant mouse (rm) Serpin A1, recombinant human Serpin A3 and rmSerpin A5 is observed.

gene symbol :

Serpina3n

accessionNumbers :

Q91WP6

applications :

Immunohistochemistry,Immunoprecipitation,Western Blot,Immunofluorescence

USD :

509 USD

alt names :

A1A;A1AT;AAT;Alpha-1-antitrypsin;alpha1AT;nNIF;PI;PI1;PRO2275;SERPINA1, Spi2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage