Reference |
---|
Tang X, Mei Y, He K, Liu R, Lv X, Zhao Y, et al. The RING-type E3 ligase RIE1 sustains leaf longevity by specifically targeting AtACS7 to fine-tune ethylene production in Arabidopsis. Proc Natl Acad Sci U S A. 2024;121:e2411271121 pubmed publisher
|
Vukovic D, Winkelvo xdf D, Kapp J, H xe4 nny A, B xfc rgisser H, Riermeier L, et al. Protein degradation kinetics measured by microinjection and live-cell fluorescence microscopy. Sci Rep. 2024;14:27153 pubmed publisher
|
Lu J, Yu J, Liu P, Gu J, Chen Y, Zhang T, et al. Ubiquitin-mediated degradation of SlPsbS regulates low night temperature tolerance in tomatoes. Cell Rep. 2024;43:114757 pubmed publisher
|
Salunkhe S, Daley J, Kaur H, Tomimatsu N, Xue C, Raina V, et al. Promotion of DNA end resection by BRCA1-BARD1 in homologous recombination. Nature. 2024;634:482-491 pubmed publisher
|
Chan A, Haley R, Najar M, González Martínez D, Bugaj L, Burslem G, et al. Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins. Nat Commun. 2024;15:5808 pubmed publisher
|
Wang S, Li H, Liu X, Yin T, Li T, Zheng M, et al. VHL suppresses UBE3B-mediated breast tumor growth and metastasis. Cell Death Dis. 2024;15:446 pubmed publisher
|
Kubori T, Arasaki K, Oide H, Kitao T, Nagai H. Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics. elife. 2024;12: pubmed publisher
|
Burge R, Jameson K, Geoghegan V, Dowle A, Mottram J, Wilkinson A. Formation of functional E3 ligase complexes with UBC2 and UEV1 of Leishmania mexicana. Mol Biochem Parasitol. 2024;258:111619 pubmed publisher
|
Radko Juettner S, Yue H, Myers J, Carter R, Robertson A, Mittal P, et al. Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature. 2024;628:442-449 pubmed publisher
|
Wang J, Baddock H, Mafi A, Foe I, Bratkowski M, Lin T, et al. Structure of the p53 degradation complex from HPV16. Nat Commun. 2024;15:1842 pubmed publisher
|
Wu K, DeVita R, Pan Z. Monoubiquitination empowers ubiquitin chain elongation. J Biol Chem. 2024;300:105753 pubmed publisher
|
Zhu K, Suskiewicz M, Chatrin C, Str xf8 mland x, Dorsey B, Aucagne V, et al. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids. Nucleic Acids Res. 2024;52:801-815 pubmed publisher
|
Tian T, Xie X, Yi W, Zhou Y, Xu Y, Wang Z, et al. FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation. Cell Rep. 2023;42:113362 pubmed publisher
|
Li P, Zhen Y, Kim C, Liu Z, Hao J, Deng H, et al. Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer. Sci Adv. 2023;9:eadg7752 pubmed publisher
|
VanDyke D, Xu L, Sargunas P, Gilbreth R, Baca M, Gao C, et al. Redirecting the specificity of tripartite motif containing-21 scaffolds using a novel discovery and design approach. J Biol Chem. 2023;299:105381 pubmed publisher
|
Sun J, Huang S, Lu Q, Li S, Zhao S, Zheng X, et al. UV-B irradiation-activated E3 ligase GmILPA1 modulates gibberellin catabolism to increase plant height in soybean. Nat Commun. 2023;14:6262 pubmed publisher
|
Yuan F, Gollapudi S, Day K, Ashby G, Sangani A, Malady B, et al. Ubiquitin-driven protein condensation promotes clathrin-mediated endocytosis. bioRxiv. 2023;: pubmed publisher
|
Mueller S, Bialas J, Ryu S, Catone N, Aichem A. The ubiquitin-like modifier FAT10 covalently modifies HUWE1 and strengthens the interaction of AMBRA1 and HUWE1. PLoS ONE. 2023;18:e0290002 pubmed publisher
|
Li Y, Wang H, Sun B, Su G, Cang Y, Zhao L, et al. Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma. Cell Death Dis. 2023;14:494 pubmed publisher
|
Chen M, Wang K, Han Y, Yan S, Yuan H, Liu Q, et al. Identification of XAF1 as an endogenous AKT inhibitor. Cell Rep. 2023;42:112690 pubmed publisher
|
Ardah M, Radwan N, Khan E, Kitada T, Haque M. Parkin Precipitates on Mitochondria via Aggregation and Autoubiquitination. Int J Mol Sci. 2023;24: pubmed publisher
|
Monda J, Ge X, Hunkeler M, Donovan K, Ma M, Jin C, et al. HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways. Cell Rep. 2023;42:112496 pubmed publisher
|
Kong L, Sui C, Chen T, Zhang L, Zhao W, Zheng Y, et al. The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus. Cell Rep. 2023;42:112306 pubmed publisher
|
Sharma J, Mulherkar S, Chen U, Xiong Y, Bajaj L, Cho B, et al. Calpain activity is negatively regulated by a KCTD7-Cullin-3 complex via non-degradative ubiquitination. Cell Discov. 2023;9:32 pubmed publisher
|
Mevissen T, Prasad A, Walter J. TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away. Cell Rep. 2023;42:112125 pubmed publisher
|
Fan Y, Xu F, Wang R, He J. Lysine 222 in PPAR γ1 functions as the key site of MuRF2-mediated ubiquitination modification. Sci Rep. 2023;13:1999 pubmed publisher
|
Shukla P, Bissell J, Kumar S, Pokhrel S, Palani S, Radmall K, et al. Structure and functional determinants of Rad6-Bre1 subunits in the histone H2B ubiquitin-conjugating complex. Nucleic Acids Res. 2023;51:2117-2136 pubmed publisher
|
Du X, Pang J, Gu B, Si T, Chang Y, Li T, et al. A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma. Nucleic Acids Res. 2023;51:1050-1066 pubmed publisher
|
Wei W, Yang Y, Chen J, Lakshmanan P, Kuang J, Lu W, et al. MaNAC029 modulates ethylene biosynthesis and fruit quality and undergoes MaXB3-mediated proteasomal degradation during banana ripening. J Adv Res. 2023;53:33-47 pubmed publisher
|
Doblas L, H xe4 gglund P, Fuentes Lemus E, Davies M. The cysteine residue in beta-lactoglobulin reacts with oxidized tyrosine residues in beta-casein to give casein-lactoglobulin dimers. Arch Biochem Biophys. 2023;733:109482 pubmed publisher
|
Li X, Anderson D, Chang Y, Jarnik M, Machner M. VpdC is a ubiquitin-activated phospholipase effector that regulates Legionella vacuole expansion during infection. Proc Natl Acad Sci U S A. 2022;119:e2209149119 pubmed publisher
|
Liu T, Yang H, Zhuo F, Yang Z, Zhao M, Guo Q, et al. Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy. EBioMedicine. 2022;86:104353 pubmed publisher
|
Kochenova O, Mukkavalli S, Raman M, Walter J. Cooperative assembly of p97 complexes involved in replication termination. Nat Commun. 2022;13:6591 pubmed publisher
|
Xiang Y, Yu J, Liao B, Shan J, Ye W, Dong N, et al. An α/β hydrolase family member negatively regulates salt tolerance but promotes flowering through three distinct functions in rice. Mol Plant. 2022;15:1908-1930 pubmed publisher
|
Zhu K, Suskiewicz M, Hlou x161 ek Kasun A, Meudal H, Miko x10d A, Aucagne V, et al. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates. Sci Adv. 2022;8:eadd4253 pubmed publisher
|
Zhang L, Jiang L, Yu L, Li Q, Tian X, He J, et al. Inhibition of UBA6 by inosine augments tumour immunogenicity and responses. Nat Commun. 2022;13:5413 pubmed publisher
|
Ma X, Ma X, Zhu L, Zhao Y, Chen M, Li T, et al. The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling. Oncogenesis. 2022;11:40 pubmed publisher
|
Zhang S, Zou S, Yin D, Zhao L, Finley D, Wu Z, et al. USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature. 2022;605:567-574 pubmed publisher
|
Deshmukh D, Xu J, Yang X, Shimelis H, Fang S, Qiu Y. Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6. Pharmaceutics. 2022;14: pubmed publisher
|
Lee S, Garofano L, Ko A, D Angelo F, Frangaj B, Sommer D, et al. Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription. Nat Commun. 2022;13:2089 pubmed publisher
|
Johnson O, Nadel C, Carroll E, Arhar T, Gestwicki J. Two distinct classes of cochaperones compete for the EEVD motif in heat shock protein 70 to tune its chaperone activities. J Biol Chem. 2022;298:101697 pubmed publisher
|
Zhou Y, Zheng R, Liu S, Disoma C, Du A, Li S, et al. Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation. J Biol Chem. 2022;298:101584 pubmed publisher
|
Yoon S, Bogdanov K, Wallach D. Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes. Cell Death Differ. 2022;: pubmed publisher
|
Won M, Park K, Kim S, Ju E, Ko Y, Yoo H, et al. ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB. Cell Death Differ. 2022;29:1152-1163 pubmed publisher
|
Fuentes Lemus E, Reyes J, Gamon L, López Alarcón C, Davies M. Effect of macromolecular crowding on protein oxidation: Consequences on the rate, extent and oxidation pathways. Redox Biol. 2021;48:102202 pubmed publisher
|
Zhou H, Zaher M, Walter J, Brown A. Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates. Nucleic Acids Res. 2021;49:13194-13206 pubmed publisher
|
Ibarra R, Borror H, Hart B, Gardner R, Kleiger G. The San1 Ubiquitin Ligase Avidly Recognizes Misfolded Proteins through Multiple Substrate Binding Sites. Biomolecules. 2021;11: pubmed publisher
|
Mukhopadhyay C, Yang C, Xu L, Liu D, Wang Y, Huang D, et al. G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer. Nat Commun. 2021;12:6662 pubmed publisher
|
Zhu Q, Huang J, Huang H, Li H, Yi P, Kloeber J, et al. RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination. Nat Commun. 2021;12:6653 pubmed publisher
|
Mahlokozera T, Patel B, Chen H, Desouza P, Qu X, Mao D, et al. Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma. Nat Commun. 2021;12:6321 pubmed publisher
|
Bunch H, Jeong J, Kang K, Jo D, Cong A, Kim D, et al. BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ. Open Biol. 2021;11:210221 pubmed publisher
|
Manne R, Agrawal Y, Malonia S, Banday S, Edachery S, Patel A, et al. FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX. J Biol Chem. 2021;297:101253 pubmed publisher
|
Liu Y, Qin C, Rao Y, Ngo C, Feng J, Zhao J, et al. SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response. MBio. 2021;12:e0233521 pubmed publisher
|
Kokic G, Wagner F, Chernev A, Urlaub H, Cramer P. Structural basis of human transcription-DNA repair coupling. Nature. 2021;598:368-372 pubmed publisher
|
Sun Y, Chen J, Huang S, Su Y, Wang W, Agama K, et al. PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation. Nat Commun. 2021;12:5010 pubmed publisher
|
Davies C, Vidal S, Phu L, Sudhamsu J, Hinkle T, Chan Rosenberg S, et al. Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W. Nat Commun. 2021;12:4608 pubmed publisher
|
Li W, Wang Y, Zhu L, DU S, Mao J, Wang Y, et al. The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization. J Cell Mol Med. 2021;25:6709-6720 pubmed publisher
|
El Manaa W, Duplan E, Goiran T, Lauritzen I, Vaillant Beuchot L, Lacas Gervais S, et al. Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology. Autophagy. 2021;:1-23 pubmed publisher
|
Gao P, Ma X, Yuan M, Yi Y, Liu G, Wen M, et al. E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3. Nat Commun. 2021;12:1194 pubmed publisher
|
Zhao S, Kieser A, Li H, Reinking H, Weickert P, Euteneuer S, et al. A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN. Nucleic Acids Res. 2021;49:902-915 pubmed publisher
|
Watzlawik J, Hou X, Fricova D, Ramnarine C, Barodia S, Gendron T, et al. Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples. Autophagy. 2021;17:2613-2628 pubmed publisher
|
Deng M, Lin J, Nowsheen S, Liu T, Zhao Y, Villalta P, et al. Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents. Sci Adv. 2020;6: pubmed publisher
|
Albert M, Brinkmann K, Pokrzywa W, Günther S, Kronke M, Hoppe T, et al. CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage. Cell Death Dis. 2020;11:740 pubmed publisher
|
Toma Fukai S, Hibi R, Naganuma T, Sakai M, Saijo S, Shimizu N, et al. Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure. J Biol Chem. 2020;295:14630-14639 pubmed publisher
|
Cathcart A, Bird G, Wales T, Herce H, Harvey E, Hauseman Z, et al. Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer. Nat Chem Biol. 2020;16:1218-1226 pubmed publisher
|
Gatti M, Imhof R, Huang Q, Baudis M, Altmeyer M. The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency. Cell Rep. 2020;32:107985 pubmed publisher
|
Kim C, Noda T, Kim H, Kim G, Park S, Na Y, et al. PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis. Cell Rep. 2020;32:107950 pubmed publisher
|
Matyskiela M, Clayton T, Zheng X, Mayne C, Tran E, Carpenter A, et al. Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex. Nat Struct Mol Biol. 2020;27:319-322 pubmed publisher
|
Li F, Yuan P, Rao M, Jin C, Tang W, Rong Y, et al. piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis. Nat Cell Biol. 2020;22:425-438 pubmed publisher
|
Yoo Y, Park Y, Lee H, Oanh N, Cho M, Heo J, et al. Mitochondria ubiquitin ligase, MARCH5 resolves hepatitis B virus X protein aggregates in the liver pathogenesis. Cell Death Dis. 2019;10:938 pubmed publisher
|
Li X, Guo M, Cai L, Du T, Liu Y, Ding H, et al. Competitive ubiquitination activates the tumor suppressor p53. Cell Death Differ. 2020;27:1807-1818 pubmed publisher
|
Ting T, Goralski M, Klein K, Wang B, Kim J, Xie Y, et al. Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15. Cell Rep. 2019;29:1499-1510.e6 pubmed publisher
|
Sitz J, Blanchet S, Gameiro S, Biquand E, Morgan T, Galloy M, et al. Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response. Proc Natl Acad Sci U S A. 2019;116:19552-19562 pubmed publisher
|
Rycenga H, Wolfe K, Yeh E, Long D. Uncoupling of p97 ATPase activity has a dominant negative effect on protein extraction. Sci Rep. 2019;9:10329 pubmed publisher
|
Liyasova M, Ma K, Voeller D, Ryan P, Chen J, Klevit R, et al. Cbl interacts with multiple E2s in vitro and in cells. PLoS ONE. 2019;14:e0216967 pubmed publisher
|
Yin Q, Han T, Fang B, Zhang G, Zhang C, Roberts E, et al. K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling. Nat Commun. 2019;10:1870 pubmed publisher
|
Akande O, Damle P, Pop M, Sherman N, Szomju B, Litovchick L, et al. DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination. Cell Rep. 2019;26:3323-3335.e4 pubmed publisher
|
Xie C, Tan M, Lin X, Wu D, Jiang Y, Tan Y, et al. The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways. Cell Rep. 2019;26:3037-3050.e4 pubmed publisher
|
Liu B, Yi J, Yang X, Liu L, Lou X, Zhang Z, et al. MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner. Oncogene. 2019;38:2501-2515 pubmed publisher
|
Dong Y, Zhang S, Wu Z, Li X, Wang W, Zhu Y, et al. Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature. 2019;565:49-55 pubmed publisher
|
Huang X, Wang X, Yuan X, Wu W, Lobie P, Wu Z. XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation. Oncogene. 2019;38:1448-1460 pubmed publisher
|
Matyskiela M, Couto S, Zheng X, Lu G, Hui J, Stamp K, et al. SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate. Nat Chem Biol. 2018;14:981-987 pubmed publisher
|
Donovan K, An J, Nowak R, Yuan J, Fink E, Berry B, et al. Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. elife. 2018;7: pubmed publisher
|
Hou X, Fiesel F, Truban D, Castanedes Casey M, Lin W, Soto A, et al. Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease. Autophagy. 2018;14:1404-1418 pubmed publisher
|
Ito S, Ueno A, Ueda T, Nakagawa H, Taniguchi H, Kayukawa N, et al. CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells. Oncotarget. 2018;9:17645-17655 pubmed publisher
|
Valleau D, Quaile A, Cui H, Xu X, Evdokimova E, Chang C, et al. Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila. Cell Rep. 2018;23:568-583 pubmed publisher
|
de Moura T, Mozaffari Jovin S, Szabó C, Schmitzová J, Dybkov O, Cretu C, et al. Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors. Mol Cell. 2018;69:979-992.e6 pubmed publisher
|
Albee L, Laporte H, Gao X, Eby J, Cheng Y, Nevins A, et al. Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle. Open Biol. 2018;8: pubmed publisher
|
Higa M, Tanaka K, Saijo M. Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7. FEBS J. 2018;285:965-976 pubmed publisher
|
Chen X, He Z, Fu M, Wang Y, Wu H, Li X, et al. The E3 Ubiquitin Ligase Siah-1 Suppresses Avian Reovirus Infection by Targeting p10 for Degradation. J Virol. 2018;92: pubmed publisher
|
Kim S, Kim H, Kim H, Kim D, Han J, Byeon H, et al. HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer. Autophagy. 2018;14:385-403 pubmed publisher
|
Yang C, Zang W, Tang Z, Ji Y, Xu R, Yang Y, et al. A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy. Cancer Res. 2018;78:1069-1082 pubmed publisher
|
Hein J, Hertz E, Garvanska D, Kruse T, Nilsson J. Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis. Nat Cell Biol. 2017;19:1433-1440 pubmed publisher
|
Boselli M, Lee B, Robert J, Prado M, Min S, Cheng C, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017;292:19209-19225 pubmed publisher
|
Osuna B, Howard C, Kc S, Frost A, Weinberg D. In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing. elife. 2017;6: pubmed publisher
|
Kagami Y, Ono M, Yoshida K. Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis. Sci Rep. 2017;7:5583 pubmed publisher
|
Fan Z, Chen J, Kuang J, Lu W, Shan W. The Banana Fruit SINA Ubiquitin Ligase MaSINA1 Regulates the Stability of MaICE1 to be Negatively Involved in Cold Stress Response. Front Plant Sci. 2017;8:995 pubmed publisher
|
Lin B, Ke Q, Li H, Pheifer N, Velliquette D, Leaman D. Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114. Cytokine. 2017;99:186-193 pubmed publisher
|
Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, et al. BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation. Nature. 2017;546:549-553 pubmed publisher
|
Inano S, Sato K, Katsuki Y, Kobayashi W, Tanaka H, Nakajima K, et al. RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination. Mol Cell. 2017;66:622-634.e8 pubmed publisher
|
Glorian V, Allègre J, Berthelet J, Dumetier B, Boutanquoi P, Droin N, et al. DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues. Cell Death Dis. 2017;8:e2816 pubmed publisher
|
An J, Ponthier C, Sack R, Seebacher J, Stadler M, Donovan K, et al. pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase. Nat Commun. 2017;8:15398 pubmed publisher
|
Paul A, Wang B. RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage. Mol Cell. 2017;66:458-472.e5 pubmed publisher
|
Bodnar N, Rapoport T. Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex. Cell. 2017;169:722-735.e9 pubmed publisher
|
Perea Resa C, Rodriguez Milla M, Iniesto E, Rubio V, Salinas J. Prefoldins Negatively Regulate Cold Acclimation in Arabidopsis thaliana by Promoting Nuclear Proteasome-Mediated HY5 Degradation. Mol Plant. 2017;10:791-804 pubmed publisher
|
Pakdaman Y, Sanchez Guixé M, Kleppe R, Erdal S, Bustad H, Bjørkhaug L, et al. In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins. Biosci Rep. 2017;37: pubmed publisher
|
Houston K, Melvin A, Woss G, Fayer E, Waters M, Allbritton N. Development of β-Hairpin Peptides for the Measurement of SCF-Family E3 Ligase Activity in Vitro via Ornithine Ubiquitination. ACS Omega. 2017;2:1198-1206 pubmed publisher
|
Zhang X, Li B, Rezaeian A, Xu X, Chou P, Jin G, et al. H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis. Nat Commun. 2017;8:14799 pubmed publisher
|
Malonis R, Fu W, Jelcic M, Thompson M, Canter B, Tsikitis M, et al. RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling. J Biol Chem. 2017;292:7435-7451 pubmed publisher
|
Wang Q, Huang L, Hong Z, Lv Z, Mao Z, Tang Y, et al. The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response. PLoS Pathog. 2017;13:e1006264 pubmed publisher
|
He S, Cao Y, Xie P, Dong G, Zhang L. The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function. Sci Rep. 2017;7:41364 pubmed publisher
|
Hasanov E, Chen G, Chowdhury P, Weldon J, Ding Z, Jonasch E, et al. Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL. Oncogene. 2017;36:3450-3463 pubmed publisher
|
Lang X, Tang T, Jin T, Ding C, Zhou R, Jiang W. TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity. J Exp Med. 2017;214:459-473 pubmed publisher
|
Lin S, Lu S, Mulaj M, Fang B, Keeley T, Wan L, et al. Monoubiquitination Inhibits the Actin Bundling Activity of Fascin. J Biol Chem. 2016;291:27323-27333 pubmed publisher
|
Xie N, Ma L, Zhu F, Zhao W, Tian F, Yuan F, et al. Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress. Sci Rep. 2016;6:36171 pubmed publisher
|
Klosowiak J, Park S, Smith K, French M, Focia P, Freymann D, et al. Structural insights into Parkin substrate lysine targeting from minimal Miro substrates. Sci Rep. 2016;6:33019 pubmed publisher
|
Zhou W, Xu J, Li H, Xu M, Chen Z, Wei W, et al. Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage. Clin Cancer Res. 2017;23:1104-1116 pubmed publisher
|
Du L, LI Y, Fakih M, Wiatrek R, Duldulao M, Chen Z, et al. Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal. Nat Commun. 2016;7:12326 pubmed publisher
|
Matyskiela M, Lu G, Ito T, Pagarigan B, Lu C, Miller K, et al. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature. 2016;535:252-7 pubmed publisher
|
Marzahn M, Marada S, Lee J, Nourse A, Kenrick S, Zhao H, et al. Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles. EMBO J. 2016;35:1254-75 pubmed publisher
|
Zhang Q, Karnak D, Tan M, Lawrence T, Morgan M, Sun Y. FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4. Mol Cell. 2016;61:419-433 pubmed publisher
|
Ardelt P, Ebbing J, Adams F, Reiss C, Arap W, Pasqualini R, et al. An anti-ubiquitin antibody response in transitional cell carcinoma of the urinary bladder. PLoS ONE. 2015;10:e0118646 pubmed publisher
|
Sandoval D, Hill S, Ziemba A, Lewis S, Kuhlman B, Kleiger G. Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations. J Biol Chem. 2015;290:1106-18 pubmed publisher
|
Rout M, Hodge C, Markin C, Xu X, Glover J, Xiao W, et al. Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes. J Am Chem Soc. 2014;136:17446-58 pubmed publisher
|
Sanchez C, Liu C, Mayer S, Nurhasanah A, Cyrklaff M, Mu J, et al. A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. PLoS Genet. 2014;10:e1004382 pubmed publisher
|
Guicciardi M, Werneburg N, Bronk S, Franke A, Yagita H, Thomas G, et al. Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. PLoS ONE. 2014;9:e92124 pubmed publisher
|
Townley Tilson W, Wu Y, Ferguson J, Patterson C. The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2. PLoS ONE. 2014;9:e89451 pubmed publisher
|
Sivakumar S, Daum J, Tipton A, Rankin S, Gorbsky G. The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit. Mol Biol Cell. 2014;25:594-605 pubmed publisher
|
Lonskaya I, Desforges N, Hebron M, Moussa C. Ubiquitination increases parkin activity to promote autophagic ?-synuclein clearance. PLoS ONE. 2013;8:e83914 pubmed publisher
|
Tripathi A, Davis J, Staren D, Volkman B, Majetschak M. CXC chemokine receptor 4 signaling upon co-activation with stromal cell-derived factor-1? and ubiquitin. Cytokine. 2014;65:121-5 pubmed publisher
|
Liu W, Shang Y, Zeng Y, Liu C, Li Y, Zhai L, et al. Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains. EMBO J. 2014;33:46-61 pubmed publisher
|
Rajbhandari P, Schalper K, Solodin N, Ellison Zelski S, Ping Lu K, Rimm D, et al. Pin1 modulates ERα levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation. Oncogene. 2014;33:1438-47 pubmed publisher
|
Singer A, Schulze S, Skarina T, Xu X, Cui H, Eschen Lippold L, et al. A pathogen type III effector with a novel E3 ubiquitin ligase architecture. PLoS Pathog. 2013;9:e1003121 pubmed publisher
|
Hebron M, Lonskaya I, Sharpe K, Weerasinghe P, Algarzae N, Shekoyan A, et al. Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6). J Biol Chem. 2013;288:4103-15 pubmed publisher
|
Lu Y, Li J, Cheng D, Parameswaran B, Zhang S, Jiang Z, et al. The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation. J Biol Chem. 2012;287:41014-22 pubmed publisher
|
Shibata Y, Oyama M, Kozuka Hata H, Han X, Tanaka Y, Gohda J, et al. p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO. Nat Commun. 2012;3:1061 pubmed publisher
|
Foster S, Morgan D. The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell. 2012;47:921-32 pubmed publisher
|
Sun J, Zhou W, Kaliappan K, Nawaz Z, Slingerland J. ERα phosphorylation at Y537 by Src triggers E6-AP-ERα binding, ERα ubiquitylation, promoter occupancy, and target gene expression. Mol Endocrinol. 2012;26:1567-77 pubmed publisher
|
Varfolomeev E, Moradi E, Dynek J, Zha J, Fedorova A, Deshayes K, et al. Characterization of ML-IAP protein stability and physiological role in vivo. Biochem J. 2012;447:427-36 pubmed publisher
|
Pelisch F, Pozzi B, Risso G, Muñoz M, Srebrow A. DNA damage-induced heterogeneous nuclear ribonucleoprotein K sumoylation regulates p53 transcriptional activation. J Biol Chem. 2012;287:30789-99 pubmed publisher
|