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company name :
R&D Systems
product type :
protein
product name :
Suc-Leu-Leu-Val-Tyr-AMC (Suc-LLVY-AMC)
catalog :
S-280-05M
quantity :
5 mg
price :
153 USD
more info or order :
citations: 30
Reference
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Lan X, Hu M, Jiang L, Wang J, Meng Y, Chen X, et al. Piperlongumine overcomes imatinib resistance by inducing proteasome inhibition in chronic myelogenous leukemia cells. J Ethnopharmacol. 2023;301:115815 pubmed publisher
Tarasov K, Chakir K, Riordon D, Lyashkov A, Ahmet I, Perino M, et al. A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8. elife. 2022;11: pubmed publisher
Sbardella D, Tundo G, Mecchia A, Palumbo C, Atzori M, Levati L, et al. A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose. Cell Biosci. 2022;12:108 pubmed publisher
Tundo G, Sbardella D, Oddone F, Grasso G, Marini S, Atzori M, et al. Insulin-Degrading Enzyme Is a Non Proteasomal Target of Carfilzomib and Affects the 20S Proteasome Inhibition by the Drug. Biomolecules. 2022;12: pubmed publisher
Benvenuto M, Ciuffa S, Focaccetti C, Sbardella D, Fazi S, Scimeca M, et al. Proteasome inhibition by bortezomib parallels a reduction in head and neck cancer cells growth, and an increase in tumor-infiltrating immune cells. Sci Rep. 2021;11:19051 pubmed publisher
Hirano T, Suzuki N, Hoshi N, Tabuchi Y. Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition. Toxicol Appl Pharmacol. 2021;430:115723 pubmed publisher
Adelöf J, Wiseman J, Zetterberg M, Hernebring M. PA28α overexpressing female mice maintain exploratory behavior and capacity to prevent protein aggregation in hippocampus as they age. Aging Cell. 2021;20:e13336 pubmed publisher
Zou X, Feng X, Fu Y, Zheng Y, Ma M, Wang C, et al. Icariin Attenuates Amyloid-β (Aβ)-Induced Neuronal Insulin Resistance Through PTEN Downregulation. Front Pharmacol. 2020;11:880 pubmed publisher
Kolpakov M, Sikder K, Sarkar A, Chaki S, Shukla S, Guo X, et al. Inflammatory Serine Proteases Play a Critical Role in the Early Pathogenesis of Diabetic Cardiomyopathy. Cell Physiol Biochem. 2019;53:982-998 pubmed publisher
Nikolaou S, Cramer A, Hu L, Goh Q, Millay D, Cornwall R. Proteasome inhibition preserves longitudinal growth of denervated muscle and prevents neonatal neuromuscular contractures. JCI Insight. 2019;4: pubmed publisher
Heun Y, Grundler Groterhorst K, Pogoda K, Kraemer B, Pfeifer A, Pohl U, et al. The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity. Int J Mol Sci. 2019;20: pubmed publisher
Nemec A, Peterson A, Warnock J, Reed R, Tomko R. An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes. Cell Rep. 2019;26:483-495.e5 pubmed publisher
Li X, Huang Q, Long H, Zhang P, Su H, Liu J. A new gold(I) complex-Au(PPh3)PT is a deubiquitinase inhibitor and inhibits tumor growth. EBioMedicine. 2019;39:159-172 pubmed publisher
Eisele M, Reed R, Rudack T, Schweitzer A, Beck F, Nagy I, et al. Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating. Cell Rep. 2018;24:1301-1315.e5 pubmed publisher
Tanji K, Mori F, Miki Y, Utsumi J, Sasaki H, Kakita A, et al. YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity. Neurobiol Dis. 2018;112:14-23 pubmed publisher
Poletto M, Yang D, Fletcher S, Vendrell I, Fischer R, Legrand A, et al. Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells. Nucleic Acids Res. 2017;45:10042-10055 pubmed publisher
Wang X, Chemmama I, Yu C, Huszagh A, Xu Y, Viner R, et al. The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress. J Biol Chem. 2017;292:16310-16320 pubmed publisher
Lan X, Zhao C, Chen X, Zhang P, Zang D, Wu J, et al. Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation. Cell Death Dis. 2017;8:e2913 pubmed publisher
Ye M, Qiu H, Cao Y, Zhang M, Mi Y, Yu J, et al. Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum. Front Pharmacol. 2017;8:148 pubmed publisher
Sula Karreci E, Fan H, Uehara M, Mihali A, Singh P, Kurdi A, et al. Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proc Natl Acad Sci U S A. 2016;113:E8425-E8432 pubmed publisher
Todgham A, Crombie T, Hofmann G. The effect of temperature adaptation on the ubiquitin-proteasome pathway in notothenioid fishes. J Exp Biol. 2017;220:369-378 pubmed publisher
Braten O, Livneh I, Ziv T, Admon A, Kehat I, Caspi L, et al. Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination. Proc Natl Acad Sci U S A. 2016;113:E4639-47 pubmed publisher
Lee S, Levitsky K, Parlati F, Bennett M, Arastu Kapur S, Kellerman L, et al. Clinical activity of carfilzomib correlates with inhibition of multiple proteasome subunits: application of a novel pharmacodynamic assay. Br J Haematol. 2016;173:884-95 pubmed publisher
Li H, O Donoghue A, van der Linden W, Xie S, Yoo E, Foe I, et al. Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature. 2016;530:233-6 pubmed publisher
Shanmugam M, Li D, Gao S, Fefelova N, Shah V, Voit A, et al. Cardiac specific expression of threonine 5 to alanine mutant sarcolipin results in structural remodeling and diastolic dysfunction. PLoS ONE. 2015;10:e0115822 pubmed publisher
Wang K, Bai Y, Wang J, Zhang J. Inhibitory effects of Schisandra chinensis on acetaminophen-induced hepatotoxicity. Mol Med Rep. 2014;9:1813-9 pubmed publisher
Cho K, Patil H, Senda E, Wang J, Yi H, Qiu S, et al. Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. J Biol Chem. 2014;289:4600-25 pubmed publisher
Kirk Ballard H, Wang Z, Acharya P, Zhang X, Yu Y, Kilroy G, et al. An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes. PLoS ONE. 2013;8:e57112 pubmed publisher
Henle A, Erskine C, Benson L, Clynes R, Knutson K. Enzymatic discovery of a HER-2/neu epitope that generates cross-reactive T cells. J Immunol. 2013;190:479-88 pubmed publisher
product information
master code :
S-280
SKU :
S-280-05M
product name :
Suc-Leu-Leu-Val-Tyr-AMC (Suc-LLVY-AMC)
unit size :
5 mg
target :
Proteasome Substrates
category :
Peptides
species :
Multi-Species
source short :
Synthetic
USD :
153 USD
storage :
Store the unopened product at -20 to -70 ░C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.