Human LXR alpha/NR1H3 Ligand Binding Domain Antibody | R&D Systems PP-PPZ0412-00 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human LXR alpha/NR1H3 Ligand Binding Domain Antibody

catalog :

PP-PPZ0412-00

quantity :

100 ug

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PPZ0412

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 10

Reference
Korenfeld N, Gorbonos T, Romero Florian M, Rotaro D, Goldberg D, Radushkevitz Frishman T, et al. LXR-dependent enhancer activation regulates the temporal organization of the liver's response to refeeding leading to lipogenic gene overshoot. PLoS Biol. 2024;22:e3002735 pubmed publisher
Lianto P, Hutchinson S, Moore J, Hughes T, Thorne J. Characterization and prognostic value of LXR splice variants in triple-negative breast cancer. iScience. 2021;24:103212 pubmed publisher
Kain J, Wei X, Reddy N, Price A, Woods C, Bochkis I. Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα. Mol Metab. 2021;53:101291 pubmed publisher
Hutchinson S, Websdale A, Cioccoloni G, R xf8 berg Larsen H, Lianto P, Kim B, et al. Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer. Oncogene. 2021;40:2872-2883 pubmed publisher
Moldavski O, Zushin P, Berdan C, van Eijkeren R, Jiang X, Qian M, et al. 4β-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor. J Lipid Res. 2021;62:100051 pubmed publisher
Fan Q, Nørgaard R, Grytten I, Ness C, Lucas C, Vekterud K, et al. LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction. Cells. 2020;9: pubmed publisher
Liebergall S, Angdisen J, Chan S, Chang Y, Osborne T, Koeppel A, et al. Inflammation Triggers Liver X Receptor-Dependent Lipogenesis. Mol Cell Biol. 2020;40: pubmed publisher
Della Torre S, Mitro N, Fontana R, Gomaraschi M, Favari E, Recordati C, et al. An Essential Role for Liver ERα in Coupling Hepatic Metabolism to the Reproductive Cycle. Cell Rep. 2016;15:360-71 pubmed publisher
Torocsik D, Baráth M, Benko S, Szeles L, Dezso B, Poliska S, et al. Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli. J Immunol. 2010;184:5456-65 pubmed publisher
Smoak K, Madenspacher J, Jeyaseelan S, Williams B, Dixon D, Poch K, et al. Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense. J Immunol. 2008;180:3305-12 pubmed

product information

brand :

R&D Systems

master code :

PP-PPZ0412-00

SKU :

PP-PPZ0412-00

product name :

Human LXR alpha/NR1H3 Ligand Binding Domain Antibody

unit size :

100 ug

seo description :

The Human LXR alpha/NR1H3 Ligand Binding Domain Antibody from R&D Systems is a mouse monoclonal antibody to LXR alpha/NR1H3. This antibody reacts with human,mouse,transgenic mouse. The Human LXR alpha/NR1H3 Ligand Binding Domain Antibody has been validated for the following applications: Chromatin Immunoprecipitation (ChIP),Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry,Immunoprecipitation,Gel Supershift Assay.

target :

LXR alpha/NR1H3

category :

Primary Antibodies

buffer :

A liquid formulation in physiologic saline with 0.1% NaN3.

clonality :

Monoclonal

clone :

PPZ0412

conjugate :

Unconjugated

dilution :

Western Blot, Immunohistochemistry, Immunoprecipitation, Gel Supershift Assay

host :

Mouse

isotype :

IgG2a

species :

Human,Mouse,Transgenic Mouse

gene symbol :

NR1H3

applications :

Immunohistochemistry,Immunoprecipitation,Gel Supershift Assay,Western Blot,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation (ChIP)

USD :

469 USD

alt names :

alpha, Liver X receptor alpha, liver X receptor-alpha, LXRA, NR1H3, Nuclear receptor subfamily 1 group H member 3, nuclear receptor subfamily 1, group H, member 3, oxysterols receptor LXR-alpha, RLD-1

storage :

Store the unopened product at -70 ░C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

R&D Systems product webpage