product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human HNF-4 alpha/NR2A1 Antibody
catalog :
PP-K9218-00
quantity :
100 ug
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K9218
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 14
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 4c
Shin J, Jeong J, Choi J, Lim J, Dinesh R, Braverman J, et al. Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1. iScience. 2021;24:102411 pubmed publisher
Shin J, Park J, Lim J, Jeong J, Dinesh R, Maher S, et al. Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties. elife. 2024;13: pubmed publisher
Deol P, Ruegger P, Logan G, Shawki A, Li J, Mitchell J, et al. Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice. Gut Microbes. 2023;15:2229945 pubmed publisher
Tian C, Li L, Fan L, Brown A, Norris E, Morrison M, et al. A hepatoprotective role of peritumoral non-parenchymal cells in early liver tumorigenesis. Dis Model Mech. 2023;16: pubmed publisher
Li G, Li X, Yang L, Wang S, Dai Y, Fekry B, et al. Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice. Life Sci Alliance. 2022;5: pubmed publisher
Bellido Molias F, Sim A, Leong K, An O, Song Y, Ng V, et al. Antisense RNAs Influence Promoter Usage of Their Counterpart Sense Genes in Cancer. Cancer Res. 2021;81:5849-5861 pubmed publisher
Yeh M, Boukhar S, Roberts B, Dasgupta N, Daoud S. Genomic variants link to hepatitis C racial disparities. Oncotarget. 2017;8:59455-59475 pubmed publisher
Ancey P, Ecsedi S, Lambert M, Talukdar F, Cros M, Glaise D, et al. TET-Catalyzed 5-Hydroxymethylation Precedes HNF4A Promoter Choice during Differentiation of Bipotent Liver Progenitors. Stem Cell Reports. 2017;9:264-278 pubmed publisher
Zhu L, Finkelstein D, Gao C, Shi L, Wang Y, Lopez Terrada D, et al. Multi-organ Mapping of Cancer Risk. Cell. 2016;166:1132-1146.e7 pubmed publisher
Chellappa K, Deol P, Evans J, Vuong L, Chen G, Briançon N, et al. Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer. elife. 2016;5: pubmed publisher
Vuong L, Chellappa K, Dhahbi J, Deans J, Fang B, Bolotin E, et al. Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells. Mol Cell Biol. 2015;35:3471-90 pubmed publisher
Saha S, Parachoniak C, Ghanta K, Fitamant J, Ross K, Najem M, et al. Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer. Nature. 2014;513:110-4 pubmed publisher
Neve B, Le Bacquer O, Caron S, Huyvaert M, Leloire A, Poulain Godefroy O, et al. Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4? at the protein level. Diabetologia. 2014;57:785-96 pubmed publisher
Fabris L, Cadamuro M, Guido M, Spirli C, Fiorotto R, Colledan M, et al. Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for notch signaling. Am J Pathol. 2007;171:641-53 pubmed
product information
brand :
R&D Systems
master code :
PP-K9218-00
SKU :
PP-K9218-00
product name :
Human HNF-4 alpha/NR2A1 Antibody
unit size :
100 ug
seo description :
The Human HNF-4 alpha/NR2A1 Antibody from R&D Systems is a mouse monoclonal antibody to HNF-4 alpha/NR2A1. This antibody reacts with human,mouse,transgenic mouse. The Human HNF-4 alpha/NR2A1 Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen,Immunoprecipitation.
target :
HNF-4 alpha/NR2A1
category :
Primary Antibodies
buffer :
A liquid formulation in physiologic saline with 0.1% NaN3.
clonality :
Monoclonal
clone :
K9218
conjugate :
Unconjugated
dilution :
Western Blot, Immunohistochemistry 5-15 ug/mL, Immunoprecipitation
host :
Mouse
isotype :
IgG2a
species :
Human,Mouse,Transgenic Mouse
gene symbol :
HNF4A
applications :
Immunoprecipitation,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen
extended description :
Isoforms 1-6
USD :
479 USD
product details :
Isoforms 1-6
alt names :
FLJ39654, hepatic nuclear factor 4 alpha, hepatocyte nuclear factor 4, alpha, hepatocyte nuclear factor 4-alpha, HNF4 alpha, HNF4A, HNF4a7, HNF-4-alpha, HNF4alpha10/11/12, HNF4HNF4a8, MODY, MODY1, NR2A1, NR2A1HNF4a9, NR2A21, Nuclear receptor subfamily 2 group A member 1, TCF, TCF14, TCF-14, TCF14HNF4alpha, Transcription factor 14, Transcription factor HNF-4, transcription factor-14
storage :
Store the unopened product at -70 ░C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.