product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human COUP-TF II/NR2F2 Antibody
catalog :
PP-H7147-00
quantity :
100 ug
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H7147
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 46
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:300; loading ...; fig 4e
Shen Y, Shami A, Moritz L, Larose H, Manske G, Ma Q, et al. TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice. Nat Commun. 2021;12:3876 pubmed publisher
  • immunohistochemistry; mouse; loading ...
Yoshinaga S, Shin M, Kitazawa A, Ishii K, Tanuma M, Kasai A, et al. Comprehensive characterization of migration profiles of murine cerebral cortical neurons during development using FlashTag labeling. iScience. 2021;24:102277 pubmed publisher
Li J, Wiesinger A, Fokkert L, Bakker P, de Vries D, Tijsen A, et al. Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids. Cell Stem Cell. 2024;31:1667-1684.e6 pubmed publisher
Liau E, Jin S, Chen Y, Liu W, Calon M, Nedelec S, et al. Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons. Nat Commun. 2023;14:46 pubmed publisher
Li J, Wiesinger A, Fokkert L, Boukens B, Verkerk A, Christoffels V, et al. Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models. J Tissue Eng. 2022;13:20417314221127908 pubmed publisher
Yang D, Gomez Garcia J, Funakoshi S, Tran T, Fernandes I, Bader G, et al. Modeling human multi-lineage heart field development with pluripotent stem cells. Cell Stem Cell. 2022;29:1382-1401.e8 pubmed publisher
Rodriguez K, Brown P, Amato C, Nicol B, Liu C, Xu X, et al. Somatic cell fate maintenance in mouse fetal testes via autocrine/paracrine action of AMH and activin B. Nat Commun. 2022;13:4130 pubmed publisher
Feng W, Schriever H, Jiang S, Bais A, Wu H, Kostka D, et al. Computational profiling of hiPSC-derived heart organoids reveals chamber defects associated with NKX2-5 deficiency. Commun Biol. 2022;5:399 pubmed publisher
Zhu X, Guo Y, Chu C, Liu D, Duan K, Yin Y, et al. BRN2 as a key gene drives the early primate telencephalon development. Sci Adv. 2022;8:eabl7263 pubmed publisher
Liu F, Long D, Huang W, Peng W, Lan H, Zhou Y, et al. The Biphasic Effect of Retinoic Acid Signaling Pathway on the Biased Differentiation of Atrial-like and Sinoatrial Node-like Cells from hiPSC. Int J Stem Cells. 2022;15:247-257 pubmed publisher
Barroso Gonz xe1 lez J, Garc xed a Exp xf3 sito L, Galaviz P, Lynskey M, Allen J, Hoang S, et al. Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair. Cell Rep. 2021;37:110088 pubmed publisher
Sasaki K, Oguchi A, Cheng K, Murakawa Y, Okamoto I, Ohta H, et al. The embryonic ontogeny of the gonadal somatic cells in mice and monkeys. Cell Rep. 2021;35:109075 pubmed publisher
Zhao F, Grimm S, Yao H. Molecular Actions Underlying Wolffian Duct Regression in Sexual Differentiation of Murine Reproductive Tracts. Sex Dev. 2020;14:51-59 pubmed publisher
Zhao G, Weiner A, Neupauer K, De Mello Costa M, Palashikar G, Adams Tzivelekidis S, et al. Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2. Sci Adv. 2020;6: pubmed publisher
Wang L, Cheng C, Qin J, Xu M, Kao C, Shi J, et al. Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci Adv. 2020;6:eaaz8031 pubmed publisher
Mehanovic S, Mendoza Villarroel R, Viger R, Tremblay J. The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells. J Endocr Soc. 2019;3:2236-2257 pubmed publisher
Sorrells S, Paredes M, Velmeshev D, Herranz Pérez V, Sandoval K, Mayer S, et al. Immature excitatory neurons develop during adolescence in the human amygdala. Nat Commun. 2019;10:2748 pubmed publisher
Bonney S, Dennison B, Wendlandt M, Siegenthaler J. Retinoic Acid Regulates Endothelial β-catenin Expression and Pericyte Numbers in the Developing Brain Vasculature. Front Cell Neurosci. 2018;12:476 pubmed publisher
Ha S, Nair G, Absinta M, Luciano N, Reich D. Magnetic Resonance Imaging and Histopathological Visualization of Human Dural Lymphatic Vessels. Bio Protoc. 2018;8: pubmed publisher
Pedersen K, Chodavarapu H, Lazartigues E. Forkhead Box Transcription Factors of the FOXA Class Are Required for Basal Transcription of Angiotensin-Converting Enzyme 2. J Endocr Soc. 2017;1:370-384 pubmed publisher
Absinta M, Ha S, Nair G, Sati P, Luciano N, Palisoc M, et al. Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI. elife. 2017;6: pubmed publisher
Hwa J, Beckouche N, Huang L, Kram Y, Lindskog H, Wang R. Abnormal arterial-venous fusions and fate specification in mouse embryos lacking blood flow. Sci Rep. 2017;7:11965 pubmed publisher
Lee J, Protze S, Laksman Z, Backx P, Keller G. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations. Cell Stem Cell. 2017;21:179-194.e4 pubmed publisher
Smith R, Huang Y, Tian T, Vojtasova D, Mesalles Naranjo O, Pollard S, et al. The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk. J Neurosci. 2017;37:7975-7993 pubmed publisher
Close J, Yao Z, Levi B, Miller J, Bakken T, Menon V, et al. Single-Cell Profiling of an In Vitro Model of Human Interneuron Development Reveals Temporal Dynamics of Cell Type Production and Maturation. Neuron. 2017;93:1035-1048.e5 pubmed publisher
Chu M, Li T, Shen B, Cao X, Zhong H, Zhang L, et al. Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII. elife. 2016;5: pubmed publisher
Alzu bi A, Lindsay S, Kerwin J, Looi S, Khalil F, Clowry G. Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 and COUP-TFII in early fetal human telencephalon. Brain Struct Funct. 2017;222:2309-2328 pubmed publisher
Xie X, Tsai S, Tsai M. COUP-TFII regulates satellite cell function and muscular dystrophy. J Clin Invest. 2016;126:3929-3941 pubmed publisher
Bonney S, Harrison Uy S, Mishra S, MacPherson A, Choe Y, Li D, et al. Diverse Functions of Retinoic Acid in Brain Vascular Development. J Neurosci. 2016;36:7786-801 pubmed publisher
Lin S, Kao C, Lee H, Creighton C, Ittmann M, Tsai S, et al. Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun. 2016;7:11418 pubmed publisher
Tanwar V, Bylund J, Hu J, Yan J, Walthall J, Mukherjee A, et al. Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway. Stem Cells. 2014;32:1774-88 pubmed publisher
Lindskog H, Kim Y, Jelin E, Kong Y, Guevara Gallardo S, Kim T, et al. Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals. Development. 2014;141:1120-8 pubmed publisher
Al Rayyan N, Litchfield L, Ivanova M, Radde B, Cheng A, Elbedewy A, et al. 5-Aza-2-deoxycytidine and trichostatin A increase COUP-TFII expression in antiestrogen-resistant breast cancer cell lines. Cancer Lett. 2014;347:139-50 pubmed publisher
Boyer Di Ponio J, El Ayoubi F, Glacial F, Ganeshamoorthy K, Driancourt C, Godet M, et al. Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes. PLoS ONE. 2014;9:e84179 pubmed publisher
Litchfield L, Appana S, Datta S, Klinge C. COUP-TFII inhibits NFkappaB activation in endocrine-resistant breast cancer cells. Mol Cell Endocrinol. 2014;382:358-367 pubmed publisher
Schmouth J, Castellarin M, Laprise S, Banks K, Bonaguro R, McInerny S, et al. Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice. BMC Biol. 2013;11:106 pubmed publisher
Wu S, Cheng C, Lanz R, Wang T, Respress J, Ather S, et al. Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell. 2013;25:417-26 pubmed publisher
Davis R, Curtis C, Griffin C. BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development. 2013;140:1272-81 pubmed publisher
Mohammed H, D Santos C, Sérandour A, Ali H, Brown G, Atkins A, et al. Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor. Cell Rep. 2013;3:342-9 pubmed publisher
Litchfield L, Riggs K, Hockenberry A, Oliver L, Barnhart K, Cai J, et al. Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor ? transcription in breast cancer cells. PLoS ONE. 2012;7:e38278 pubmed publisher
Mayer S, Roeser M, Lachmann P, Ishii S, Suh J, Harlander S, et al. Chicken ovalbumin upstream promoter transcription factor II regulates renin gene expression. J Biol Chem. 2012;287:24483-91 pubmed publisher
van den Driesche S, Walker M, McKinnell C, Scott H, Eddie S, Mitchell R, et al. Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents. PLoS ONE. 2012;7:e37064 pubmed publisher
Rosa A, Brivanlou A. A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation. EMBO J. 2011;30:237-48 pubmed publisher
Lin F, Chen X, Qin J, Hong Y, Tsai M, Tsai S. Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development. J Clin Invest. 2010;120:1694-707 pubmed publisher
Aerbajinai W, Zhu J, Kumkhaek C, Chin K, Rodgers G. SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII. Blood. 2009;114:187-94 pubmed publisher
Perilhou A, Tourrel Cuzin C, Kharroubi I, Henique C, Fauveau V, Kitamura T, et al. The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways. Mol Cell Biol. 2008;28:6568-79 pubmed publisher
product information
brand :
R&D Systems
master code :
PP-H7147-00
SKU :
PP-H7147-00
product name :
Human COUP-TF II/NR2F2 Antibody
unit size :
100 ug
seo description :
The Human COUP-TF II/NR2F2 Antibody from R&D Systems is a mouse monoclonal antibody to COUP-TF II/NR2F2. This antibody reacts with human,mouse,primate,primate - macaca fascicularis (crab-eating monkey or cynomolgus macaque),rat. The Human COUP-TF II/NR2F2 Antibody has been validated for the following applications: Immunocytochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Chromatin Immunoprecipitation (ChIP).
target :
COUP-TF II/NR2F2
category :
Primary Antibodies
buffer :
A liquid formulation in physiologic saline with 0.1% NaN3.
clonality :
Monoclonal
clone :
H7147
conjugate :
Unconjugated
dilution :
Western Blot, Immunohistochemistry, Immunoprecipitation
host :
Mouse
immunogen :
Recombinant human COUP-TF II/NR2F2, Amino Acids 43-64
isotype :
IgG2a
purity :
Protein A or G purified from ascites
species :
Human,Mouse,Primate,Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque),Rat
specificity :
This antibody specifically recognizes human COUP-TF II and cross-reacts with rat COUP-TF II. This antibody does not cross-react with human COUP-TF I or EAR2. Not yet tested in other species.
gene symbol :
NR2F2
top caption :
Detection of Human COUP-TF II/NR2F2 by Knockdown Validated
applications :
Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry
USD :
479 USD
alt names :
Apolipoprotein A-I regulatory protein 1, ARP-1, ARP1ADP-ribosylation factor related protein 1, chicken ovalbumin upstream promoter transcription factor 2, COUP transcription factor 2, COUP transcription factor II, COUPTF II, COUP-TF II, COUP-TF2, COUPTFB, COUPTFII, COUP-TFII, MGC117452, NR2F2, Nuclear receptor subfamily 2 group F member 2, nuclear receptor subfamily 2, group F, member 2, SVP40, TFCOUP2apolipoprotein AI regulatory protein 1
storage :
This antibody is stable for greater than six months when held at -20░ C in a manual defrost freezer or at -70░ C. Upon thawing, the antibody can be stored at 2░ - 8░ C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.