product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human HNF-4 alpha/NR2A1 Antibody
catalog :
PP-H6939-00
quantity :
100 ug
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H6939
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - frozen section, proximity ligation assay
more info or order :
R&D Systems product webpage
citations: 10
Reference
Deol P, Ruegger P, Logan G, Shawki A, Li J, Mitchell J, et al. Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice. Gut Microbes. 2023;15:2229945 pubmed publisher
Wang Z, Zhang X, Tian X, Yang Y, Ma L, Wang J, et al. CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma. Oncol Rep. 2021;45: pubmed publisher
Ni Z, Lu W, Li Q, Han C, Yuan T, Sun N, et al. Analysis of the HNF4A isoform-regulated transcriptome identifies CCL15 as a downstream target in gastric carcinogenesis. Cancer Biol Med. 2021;18:530-46 pubmed publisher
Zhang X, Du L, Qiao Y, Zhang X, Zheng W, Wu Q, et al. Ferroptosis is governed by differential regulation of transcription in liver cancer. Redox Biol. 2019;24:101211 pubmed publisher
Tata P, Chow R, Saladi S, Tata A, Konkimalla A, Bara A, et al. Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. Dev Cell. 2018;44:679-693.e5 pubmed publisher
Ancey P, Ecsedi S, Lambert M, Talukdar F, Cros M, Glaise D, et al. TET-Catalyzed 5-Hydroxymethylation Precedes HNF4A Promoter Choice during Differentiation of Bipotent Liver Progenitors. Stem Cell Reports. 2017;9:264-278 pubmed publisher
Chellappa K, Deol P, Evans J, Vuong L, Chen G, Briançon N, et al. Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer. elife. 2016;5: pubmed publisher
Vuong L, Chellappa K, Dhahbi J, Deans J, Fang B, Bolotin E, et al. Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells. Mol Cell Biol. 2015;35:3471-90 pubmed publisher
Saha S, Parachoniak C, Ghanta K, Fitamant J, Ross K, Najem M, et al. Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer. Nature. 2014;513:110-4 pubmed publisher
Huang J, Levitsky L, Rhoads D. Novel P2 promoter-derived HNF4alpha isoforms with different N-terminus generated by alternate exon insertion. Exp Cell Res. 2009;315:1200-11 pubmed
product information
brand :
R&D Systems
master code :
PP-H6939-00
SKU :
PP-H6939-00
product name :
Human HNF-4 alpha/NR2A1 Antibody
unit size :
100 ug
seo description :
The Human HNF-4 alpha/NR2A1 Antibody from R&D Systems is a mouse monoclonal antibody to HNF-4 alpha/NR2A1. This antibody reacts with human,mouse. The Human HNF-4 alpha/NR2A1 Antibody has been validated for the following applications: Mobility Shift Assay,Immunoprecipitation,Western Blot,Proximity Ligation Assay,Immunohistochemistry,Immunohistochemistry-Frozen,Chromatin Immunoprecipitation (ChIP).
target :
HNF-4 alpha/NR2A1
category :
Primary Antibodies
buffer :
A liquid formulation in physiologic saline with 0.1% NaN3.
clonality :
Monoclonal
clone :
H6939
conjugate :
Unconjugated
dilution :
Western Blot, Immunohistochemistry 5-15 ug/mL, Immunoprecipitation
host :
Mouse
isotype :
IgG1
species :
Human,Mouse
gene symbol :
HNF4A
applications :
Mobility Shift Assay,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Frozen,Proximity Ligation Assay,Chromatin Immunoprecipitation (ChIP)
extended description :
Isoforms 7-9
USD :
479 USD
product details :
Isoforms 7-9
alt names :
FLJ39654, hepatic nuclear factor 4 alpha, hepatocyte nuclear factor 4, alpha, hepatocyte nuclear factor 4-alpha, HNF4 alpha, HNF4A, HNF4a7, HNF-4-alpha, HNF4alpha10/11/12, HNF4HNF4a8, MODY, MODY1, NR2A1, NR2A1HNF4a9, NR2A21, Nuclear receptor subfamily 2 group A member 1, TCF, TCF14, TCF-14, TCF14HNF4alpha, Transcription factor 14, Transcription factor HNF-4, transcription factor-14
storage :
Store the unopened product at -70 ░C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.