Human LRH-1/NR5A2 Antibody | R&D Systems PP-H2325-00 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human LRH-1/NR5A2 Antibody

catalog :

PP-H2325-00

quantity :

100 ug

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

H2325

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 16

Reference
Nguyen N, Chang E, Chauvin M, Sicher N, Kashiwagi A, Nagykery N, et al. AMH protects the ovary from doxorubicin by regulating cell fate and the response to DNA damage. bioRxiv. 2024;: pubmed publisher
Birgersson M, Indukuri R, Lindquist L, Stepanauskaite L, Luo Q, Deng Q, et al. Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1. BMC Biol. 2023;21:277 pubmed publisher
Zapata R, Zhang D, Libster A, Porcu A, Montilla Perez P, Nur A, et al. Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia. Mol Psychiatry. 2023;28:1857-1867 pubmed publisher
Son J, Du W, Esposito M, Shariati K, Ding H, Kang Y, et al. Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure. Nat Commun. 2023;14:558 pubmed publisher
Sun Y, Demagny H, Fauré A, Pontanari F, Jalil A, Bresciani N, et al. Asparagine protects pericentral hepatocytes during acute liver injury. J Clin Invest. 2023;133: pubmed publisher
Kim K, Wu Y, Yoon J, Adachi K, Wu G, Velychko S, et al. Reprogramming competence of OCT factors is determined by transactivation domains. Sci Adv. 2020;6: pubmed publisher
Seacrist C, Kuenze G, Hoffmann R, Moeller B, Burke J, Meiler J, et al. Integrated Structural Modeling of Full-Length LRH-1 Reveals Inter-domain Interactions Contribute to Receptor Structure and Function. Structure. 2020;28:830-846.e9 pubmed publisher
Milona A, Massafra V, Vos H, Naik J, Artigas N, Paterson H, et al. Steroidogenic control of liver metabolism through a nuclear receptor-network. Mol Metab. 2019;30:221-229 pubmed publisher
Bayrer J, Wang H, Nattiv R, Suzawa M, Escusa H, Fletterick R, et al. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun. 2018;9:4055 pubmed publisher
Zou A, Magee N, Deng F, Lehn S, Zhong C, Zhang Y. Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis. J Biol Chem. 2018;293:8656-8671 pubmed publisher
Miranda D, Krause W, Cazenave Gassiot A, Suzawa M, Escusa H, Foo J, et al. LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity. JCI Insight. 2018;3: pubmed publisher
Wagner M, Choi S, Panzitt K, Mamrosh J, Lee J, Zaufel A, et al. Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism. Hepatology. 2016;63:95-106 pubmed publisher
Bayrer J, Mukkamala S, Sablin E, Webb P, Fletterick R. Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs. Proc Natl Acad Sci U S A. 2015;112:2467-72 pubmed publisher
Chong H, Biesinger J, Seo Y, Xie X, Osborne T. Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR. BMC Genomics. 2012;13:51 pubmed publisher
Holmstrom S, Deering T, Swift G, Poelwijk F, Mangelsdorf D, Kliewer S, et al. LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function. Genes Dev. 2011;25:1674-9 pubmed publisher
Guo G, Smith A. A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency. Development. 2010;137:3185-92 pubmed publisher

product information

master code :

PP-H2325-00

SKU :

PP-H2325-00

product name :

Human LRH-1/NR5A2 Antibody

unit size :

100 ug

description :

The Human LRH-1/NR5A2 Antibody from R&D Systems is a mouse monoclonal antibody to LRH-1/NR5A2. This antibody reacts with human,mouse. The Human LRH-1/NR5A2 Antibody has been validated for the following applications: Western Blot,Immunocytochemistry,Immunoprecipitation,Immunohistochemistry,Chromatin Immunoprecipitation (ChIP),Direct ELISA.

target :

LRH-1/NR5A2

category :

Primary Antibodies

buffer :

A liquid formulation in physiologic saline with 0.1% NaN3.

clonality :

Monoclonal

clone :

H2325

conjugate :

Unconjugated

host :

Mouse

immunogen :

Recombinant human LRH-1/NR5A2, aa 161-280

isotype :

IgG3

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

This antibody specifically recognizes human LRH-1 alpha and LRH-1▀ and cross-reacts with mouse and rat LRH-1. Not yet tested in other species.

gene symbol :

NR5A2

applications :

Western Blot,Immunocytochemistry,Immunoprecipitation,Immunohistochemistry,Chromatin Immunoprecipitation (ChIP),Direct ELISA

USD :

469 USD

alt names :

Alpha-1-fetoprotein transcription factor, B1-binding factor, b1-binding factor, hepatocyte transcription factor which activates enhancer IIof hepatitis B virus, B1F, B1F2, fetoprotein-alpha 1 (AFP) transcription factor, FTFLRH1, FTZ-F1, FTZ-F1 beta, FTZ-F1beta, HB1F, hB1F-2, hB1FCYP7A promoter-binding factor, Hepatocytic transcription factor, Liver receptor homolog 1, liver receptor homolog-1, LRH1, LRH-1CPF, NR5A2, nuclear receptor NR5A2, nuclear receptor subfamily 5 group A member 2, nuclear receptor subfamily 5, group A, member 2

storage :

This antibody is stable for greater than six months when held at -20 ░C in a manual defrost freezer or at -70 ░C. Upon thawing, the antibody can be stored at 2-8 ░C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.

more info or order :

R&D Systems product webpage