product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse GLP/EHMT1 Antibody
catalog :
PP-B0422-00
quantity :
100 ug
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B0422
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunoprecipitation
more info or order :
R&D Systems product webpage
citations: 19
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:500; loading ...; fig 1j
Dahlet T, Truss M, Frede U, Al Adhami H, Bardet A, Dumas M, et al. E2F6 initiates stable epigenetic silencing of germline genes during embryonic development. Nat Commun. 2021;12:3582 pubmed publisher
Able A, Richard A, Stephens J. TNFα Effects on Adipocytes Are Influenced by the Presence of Lysine Methyltransferases, G9a (EHMT2) and GLP (EHMT1). Biology (Basel). 2023;12: pubmed publisher
Swaminathan J, Maegawa S, Shaik S, Sharma A, Bravo Alegria J, Guo L, et al. Cross-Talk Between Histone Methyltransferases and Demethylases Regulate REST Transcription During Neurogenesis. Front Oncol. 2022;12:855167 pubmed publisher
Yuan J, Chang S, Yin S, Liu Z, Cheng X, Liu X, et al. Two conserved epigenetic regulators prevent healthy ageing. Nature. 2020;579:118-122 pubmed publisher
Roy A, Ghosh A, Kumar B, Chandran B. IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP. elife. 2019;8: pubmed publisher
Zylicz J, Borensztein M, Wong F, Huang Y, Lee C, Dietmann S, et al. G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst. elife. 2018;7: pubmed publisher
Tu S, Narendra V, Yamaji M, Vidal S, Rojas L, Wang X, et al. Co-repressor CBFA2T2 regulates pluripotency and germline development. Nature. 2016;534:387-90 pubmed publisher
Han P, Li W, Yang J, Shang C, Lin C, Cheng W, et al. Epigenetic response to environmental stress: Assembly of BRG1-G9a/GLP-DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts. Biochim Biophys Acta. 2016;1863:1772-81 pubmed publisher
Zylicz J, Dietmann S, Günesdogan U, Hackett J, Cougot D, Lee C, et al. Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development. elife. 2015;4: pubmed publisher
Liu J, Magri L, Zhang F, Marsh N, Albrecht S, Huynh J, et al. Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation. J Neurosci. 2015;35:352-65 pubmed publisher
Di Giacomo M, Comazzetto S, Sampath S, Sampath S, O Carroll D. G9a co-suppresses LINE1 elements in spermatogonia. Epigenetics Chromatin. 2014;7:24 pubmed publisher
Loh S, Ng W, Yeo K, Lim Y, Ea C. Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment. PLoS ONE. 2014;9:e103915 pubmed publisher
Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, et al. The methyltransferase G9a regulates HoxA9-dependent transcription in AML. Genes Dev. 2014;28:317-27 pubmed publisher
Maksakova I, Thompson P, Goyal P, Jones S, Singh P, Karimi M, et al. Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells. Epigenetics Chromatin. 2013;6:15 pubmed publisher
Mund A, Schubert T, Staege H, Kinkley S, Reumann K, Kriegs M, et al. SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response. Nucleic Acids Res. 2012;40:11363-79 pubmed publisher
Ea C, Hao S, Yeo K, Baltimore D. EHMT1 protein binds to nuclear factor-?B p50 and represses gene expression. J Biol Chem. 2012;287:31207-17 pubmed publisher
Ceol C, Houvras Y, Jane Valbuena J, Bilodeau S, Orlando D, Battisti V, et al. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature. 2011;471:513-7 pubmed publisher
Schaefer A, Sampath S, Intrator A, Min A, Gertler T, Surmeier D, et al. Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron. 2009;64:678-91 pubmed publisher
Dong K, Maksakova I, Mohn F, Leung D, Appanah R, Lee S, et al. DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J. 2008;27:2691-701 pubmed publisher
product information
brand :
R&D Systems
master code :
PP-B0422-00
SKU :
PP-B0422-00
product name :
Human/Mouse GLP/EHMT1 Antibody
unit size :
100 ug
seo description :
The Human/Mouse GLP/EHMT1 Antibody from R&D Systems is a mouse monoclonal antibody to GLP/EHMT1. This antibody reacts with human,mouse,rat. The Human/Mouse GLP/EHMT1 Antibody has been validated for the following applications: Immunoprecipitation,Western Blot,Immunohistochemistry,Direct ELISA.
target :
GLP/EHMT1
category :
Primary Antibodies
buffer :
A liquid formulation in physiologic saline with 0.1% NaN3.
clonality :
Monoclonal
clone :
B0422
conjugate :
Unconjugated
dilution :
Western Blot, Immunohistochemistry, Immunoprecipitation, Direct ELISA
host :
Mouse
immunogen :
Recombinant mouse GLP/EHMT1, aa 134-234
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Rat
specificity :
This antibody specifically recognizes mouse GLP and cross-reacts with human GLP. Not yet tested in other species.
gene symbol :
EHMT1
applications :
Direct ELISA,Immunohistochemistry,Immunoprecipitation,Western Blot
USD :
479 USD
alt names :
DEL9q34, EC 2.1.1.-, EC 2.1.1.43, EHMT1, euchromatic histone-lysine N-methyltransferase 1H3-K9-HMTase 5, Eu-HMTase1, Eu-HMTase1DEL9q34, EUHMTASE1FP13812, FLJ12879, G9a-like protein 1, GLP, GLP1, H3 lysine-9 specific 5, KIAA1876euchromatic histone methyltransferase 1, KMT1D, KMT1DDKFZp667M072, Lysine N-methyltransferase 1D
storage :
This antibody is stable for greater than six months when held at -20 ░C in a manual defrost freezer or at -70 ░C. Upon thawing, the antibody can be stored at 2-8 ░C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.