Human FXR/NR1H4 Antibody | R&D Systems PP-A9033A-00 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human FXR/NR1H4 Antibody

catalog :

PP-A9033A-00

quantity :

100 ug

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

A9033A

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; loading ...; fig s4b	Wang X, Xie C, Libby A, Ranjit S, Levi J, Myakala K, et al. The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice. J Biol Chem. 2022;298:102530 pubmed publisher
immunohistochemistry - paraffin section; human; 1:300; fig 1e	Nortunen M, V xe4 kiparta N, Porvari K, Saarnio J, Karttunen T, Huhta H. Pathophysiology of reflux oesophagitis: role of Toll-like receptors 2 and 4 and Farnesoid X receptor. Virchows Arch. 2021;479:285-293 pubmed publisher
	Xue T, Wang X, Pan X, Liu M, Xu F. PTX promotes breast cancer migration and invasion by recruiting ATF4 to upregulate FGF19. Cell Signal. 2024;122:111309 pubmed publisher
	Hassan H, Onabote O, Isovic M, Passos D, Dick F, Torchia J. Regulation of Chromatin Accessibility by the Farnesoid X Receptor Is Essential for Circadian and Bile Acid Homeostasis In Vivo. Cancers (Basel). 2022;14: pubmed publisher
	Fallon C, Smyth J, Quach A, Lajczak McGinley N, O Toole A, Barrett K, et al. Pentacyclic triterpenes modulate farnesoid X receptor expression in colonic epithelial cells: Implications for colonic secretory function. J Biol Chem. 2022;298:102569 pubmed publisher
	Deng W, Fan W, Tang T, Wan H, Zhao S, Tan Y, et al. Farnesoid X Receptor Deficiency Induces Hepatic Lipid and Glucose Metabolism Disorder via Regulation of Pyruvate Dehydrogenase Kinase 4. Oxid Med Cell Longev. 2022;2022:3589525 pubmed publisher
	Li Q, Li N, Zeng Y, Wang X, Li J, Su H, et al. Nuclear receptor FXR impairs SK-Hep-1 cell migration and invasion by inhibiting the Wnt/β-catenin signaling pathway. Oncol Lett. 2020;20:161 pubmed publisher
	Absil L, Journe F, Larsimont D, Body J, Tafforeau L, Nonclercq D. Farnesoid X receptor as marker of osteotropism of breast cancers through its role in the osteomimetism of tumor cells. BMC Cancer. 2020;20:640 pubmed publisher
	Hassan H, Isovic M, Kolendowski B, Bauer Maison N, Onabote O, Cecchini M, et al. Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma. Cell Rep. 2020;31:107475 pubmed publisher
	Caron S, Huaman Samanez C, Dehondt H, Ploton M, Briand O, Lien F, et al. Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes. Mol Cell Biol. 2013;33:2202-11 pubmed publisher
	Bhargava P, Li C, Stanya K, Jacobi D, Dai L, Liu S, et al. Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways. Nat Med. 2012;18:1665-72 pubmed publisher
	Deuschle U, Schuler J, Schulz A, Schlüter T, Kinzel O, Abel U, et al. FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS ONE. 2012;7:e43044 pubmed publisher
	Prade E, Tobiasch M, Hitkova I, Schäffer I, Lian F, Xing X, et al. Bile acids down-regulate caveolin-1 in esophageal epithelial cells through sterol responsive element-binding protein. Mol Endocrinol. 2012;26:819-32 pubmed publisher
	Lian F, Xing X, Yuan G, Schafer C, Rauser S, Walch A, et al. Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage. Biochem J. 2011;438:315-23 pubmed publisher
	Lee J, Lee K, Lee J, Lee K, Jang K, Heo J, et al. Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion. Br J Cancer. 2011;104:1027-37 pubmed publisher

product information

brand :

R&D Systems

master code :

PP-A9033A-00

SKU :

PP-A9033A-00

product name :

Human FXR/NR1H4 Antibody

unit size :

100 ug

seo description :

The Human FXR/NR1H4 Antibody from R&D Systems is a mouse monoclonal antibody to FXR/NR1H4. This antibody reacts with human,mouse. The Human FXR/NR1H4 Antibody has been validated for the following applications: Western Blot,Immunoprecipitation,Immunohistochemistry,Immunohistochemistry-Paraffin,Direct ELISA.

target :

FXR/NR1H4

category :

Primary Antibodies

buffer :

A liquid formulation in physiologic saline with 0.1% NaN3

clonality :

Monoclonal

clone :

A9033A

conjugate :

Unconjugated

dilution :

Western Blot, Immunohistochemistry, Immunoprecipitation, Direct ELISA

host :

Mouse

immunogen :

Recombinant human FXR/NR1H4, aa 2-126

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

This antibody specifically recognizes human FXR and cross-reacts with rat and mouse FXR. Not yet tested in other species.

gene symbol :

NR1H4

applications :

Direct ELISA,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin

USD :

479 USD

alt names :

BAR, bile acid receptor, farnesoid X receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, FXRBAR, HRR-1, HRR1MGC163445, NR1H4, Nuclear receptor subfamily 1 group H member 4, nuclear receptor subfamily 1, group H, member 4, Retinoid X receptor-interacting protein 14, RIP14, RIP14RXR-interacting protein 14

storage :

This antibody is stable for greater than six months when held at -20 ░C in a manual defrost freezer or at -70 ░C. Upon thawing, the antibody can be stored at 2-8 ░C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.

more info or order :

R&D Systems product webpage