product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse G9a/EHMT2 Antibody
catalog :
PP-A8620A-00
quantity :
100 ug
price :
499 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
A8620A
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 17
Reference
Huang Z, Cui W, Ratnayake I, Tawil R, Pfeifer G. SMCHD1 maintains heterochromatin and genome compartments in human myoblasts. bioRxiv. 2024;: pubmed publisher
Hsu C, Chang K, Chuang T, Chu M, Lin P, Liu H, et al. High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach. Cancers (Basel). 2023;15: pubmed publisher
Able A, Richard A, Stephens J. TNFα Effects on Adipocytes Are Influenced by the Presence of Lysine Methyltransferases, G9a (EHMT2) and GLP (EHMT1). Biology (Basel). 2023;12: pubmed publisher
Yuan L, Lee W, Yang Y, Chen B, Yang C, Chen M, et al. Histone Methyltransferase G9a-Promoted Progression of Hepatocellular Carcinoma Is Targeted by Liver-Specific Hsa-miR-122. Cancers (Basel). 2021;13: pubmed publisher
Nakatsuka T, Tateishi K, Kato H, Fujiwara H, Yamamoto K, Kudo Y, et al. Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis. Cell Death Dis. 2021;12:99 pubmed publisher
Tian H, Billings T, Petkov P. EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8. Mol Biol Cell. 2021;32:1-14 pubmed publisher
Li Z, Jiao X, Di Sante G, Ertel A, Casimiro M, Wang M, et al. Cyclin D1 integrates G9a-mediated histone methylation. Oncogene. 2019;38:4232-4249 pubmed publisher
Li L, Liu W, Wang H, Yang Q, Zhang L, Jin F, et al. Mutual inhibition between HDAC9 and miR-17 regulates osteogenesis of human periodontal ligament stem cells in inflammatory conditions. Cell Death Dis. 2018;9:480 pubmed publisher
Chen R, Shun C, Yen M, Chou C, Lin M. Methyltransferase G9a promotes cervical cancer angiogenesis and decreases patient survival. Oncotarget. 2017;8:62081-62098 pubmed publisher
Gursoy Yuzugullu O, Carman C, Serafim R, Myronakis M, Valente V, Price B. Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity. Oncotarget. 2017;8:24518-24532 pubmed publisher
Liu C, Hua K, Li K, Kao H, Hong R, Ko J, et al. Histone Methyltransferase G9a Drives Chemotherapy Resistance by Regulating the Glutamate-Cysteine Ligase Catalytic Subunit in Head and Neck Squamous Cell Carcinoma. Mol Cancer Ther. 2017;16:1421-1434 pubmed publisher
Han P, Li W, Yang J, Shang C, Lin C, Cheng W, et al. Epigenetic response to environmental stress: Assembly of BRG1-G9a/GLP-DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts. Biochim Biophys Acta. 2016;1863:1772-81 pubmed publisher
Auclair G, Borgel J, Sanz L, Vallet J, Guibert S, Dumas M, et al. EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos. Genome Res. 2016;26:192-202 pubmed publisher
Li K, Hua K, Lin Y, Su C, Ko J, Hsiao M, et al. Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma. Mol Cancer. 2014;13:172 pubmed publisher
Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, et al. The methyltransferase G9a regulates HoxA9-dependent transcription in AML. Genes Dev. 2014;28:317-27 pubmed publisher
Chen M, Hua K, Kao H, Chi C, Wei L, Johansson G, et al. H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res. 2010;70:7830-40 pubmed publisher
Dong K, Maksakova I, Mohn F, Leung D, Appanah R, Lee S, et al. DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J. 2008;27:2691-701 pubmed publisher
product information
master code :
PP-A8620A-00
SKU :
PP-A8620A-00
product name :
Human/Mouse G9a/EHMT2 Antibody
unit size :
100 ug
description :
The Human/Mouse G9a/EHMT2 Antibody from R&D Systems is a mouse monoclonal antibody to G9a/EHMT2. This antibody reacts with human,mouse,transgenic mouse. The Human/Mouse G9a/EHMT2 Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry,Immunoprecipitation,Direct ELISA.
target :
G9a/EHMT2
category :
Primary Antibodies
buffer :
A liquid formulation in physiologic saline with 0.1% NaN3.
clonality :
Monoclonal
clone :
A8620A
conjugate :
Unconjugated
host :
Mouse
immunogen :
Recombinant mouse G9a/EHMT2, aa 15-114
isotype :
IgG2a
purity :
Protein A or G purified from ascites
species :
Human,Mouse
specificity :
This antibody specifically recognizes mouse G9a and cross-reacts with human G9a. Not yet tested in other species.
gene symbol :
EHMT2
top caption :
Detection of Mouse G9a/EHMT2 by Western Blot
applications :
Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry,Immunoprecipitation,Direct ELISA
USD :
499 USD
alt names :
ankyrin repeat-containing protein, BAT8, C6orf30, chromosome 6 open reading frame 30, DKFZp686H08213, EC 2.1.1.-, EC 2.1.1.43, EHMT2, euchromatic histone-lysine N-methyltransferase 2HLA-B-associated transcript 8, FLJ35547, G9A histone methyltransferase, G9AEm:AF134726.3, H3-K9-HMTase 3, Histone H3-K9 methyltransferase 3, histone-lysine N-methyltransferase, H3 lysine-9 specific 3, HLA-B associated transcript 8, KMT1CNG36/G9a, Lysine N-methyltransferase 1C, NG36, Protein G9a
storage :
This antibody is stable for greater than six months when held at -20░ C in a manual defrost freezer or at -70░C. Upon thawing, the antibody can be stored at 2░ - 8░ C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.