product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Pan Caspase OPH Inhibitor Q-VD, Non-omethylated
catalog :
OPH001-01M
quantity :
1 mg
price :
236 USD
more info or order :
citations: 42
Reference
Haas M, Cherfa S, Nguyen L, Bourgoin M, Caron G, Dessauge E, et al. PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression. Nat Commun. 2025;16:256 pubmed publisher
Aktepe T, Deerain J, Hyde J, Fritzlar S, Mead E, Carrera Montoya J, et al. Norovirus-mediated translation repression promotes macrophage cell death. PLoS Pathog. 2024;20:e1012480 pubmed publisher
Liu C, Vorderbruggen M, Mu xf1 oz Trujillo C, Kim S, Katzenellenbogen J, Katzenellenbogen B, et al. NB compounds are potent and efficacious FOXM1 inhibitors in high-grade serous ovarian cancer cells. J Ovarian Res. 2024;17:94 pubmed publisher
Oliveira Mendes B, Alameh M, Ollivier B, Montnach J, Bid xe8 re N, Souaz xe9 F, et al. SARS-CoV-2 E and 3a Proteins Are Inducers of Pannexin Currents. Cells. 2023;12: pubmed publisher
Weerasinghe H, Simm C, Djajawi T, Tedja I, Lo T, Simpson D, et al. Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response. Cell Rep. 2023;42:112522 pubmed publisher
Bai F, Chen Z, Xu S, Han L, Zeng X, Huang S, et al. Wogonin attenuates neutrophilic inflammation and airway smooth muscle proliferation through inducing caspase-dependent apoptosis and inhibiting MAPK/Akt signaling in allergic airways. Int Immunopharmacol. 2022;113:109410 pubmed publisher
Dong X, Limjunyawong N, Sypek E, Wang G, Ortines R, Youn C, et al. Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022;55:1645-1662.e7 pubmed publisher
Gomes M, Palasiewicz K, Gadiyar V, Lahey K, Calianese D, Birge R, et al. Phosphatidylserine externalization by apoptotic cells is dispensable for specific recognition leading to innate apoptotic immune responses. J Biol Chem. 2022;298:102034 pubmed publisher
Giovannucci T, Salomons F, Haraldsson M, Elfman L, Wickström M, Young P, et al. Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound. Cell Death Dis. 2021;12:914 pubmed publisher
Núñez Vázquez S, Saura Esteller J, Sánchez Vera I, Guilbaud E, Cosialls A, Pons G, et al. The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells. Oncogenesis. 2021;10:64 pubmed publisher
Kratochvilova A, Ramesova A, Veselá B, Svandová E, Lesot H, Gruber R, et al. Impact of FasL Stimulation on Sclerostin Expression and Osteogenic Profile in IDG-SW3 Osteocytes. Biology (Basel). 2021;10: pubmed publisher
Samuel M, Fonseka P, Sanwlani R, Gangoda L, Chee S, Keerthikumar S, et al. Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis. Nat Commun. 2021;12:3950 pubmed publisher
Di Grazia A, Marafini I, Pedini G, Di Fusco D, Laudisi F, Dinallo V, et al. The Fragile X Mental Retardation Protein Regulates RIPK1 and Colorectal Cancer Resistance to Necroptosis. Cell Mol Gastroenterol Hepatol. 2021;11:639-658 pubmed publisher
Miles M, Hawkins C. In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations. Cell Death Dis. 2020;11:680 pubmed publisher
de las Pozas A, Reiner T, De Cesare V, Trost M, Perez Stable C. Inhibiting Multiple Deubiquitinases to Reduce Androgen Receptor Expression in Prostate Cancer Cells. Sci Rep. 2018;8:13146 pubmed publisher
Chen K, Lawlor K, von Pein J, Boucher D, Gerlic M, Croker B, et al. Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion. J Immunol. 2018;200:3341-3346 pubmed publisher
Miles M, Hawkins C. Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine. Cell Death Dis. 2017;8:e3062 pubmed publisher
Martín Estebané M, Navascués J, Sierra Martín A, Martín Guerrero S, Cuadros M, Carrasco M, et al. Onset of microglial entry into developing quail retina coincides with increased expression of active caspase-3 and is mediated by extracellular ATP and UDP. PLoS ONE. 2017;12:e0182450 pubmed publisher
Schmukler E, Wolfson E, Elazar Z, Kloog Y, Pinkas Kramarski R. Continuous treatment with FTS confers resistance to apoptosis and affects autophagy. PLoS ONE. 2017;12:e0171351 pubmed publisher
Conos S, Chen K, De Nardo D, Hara H, Whitehead L, Núñez G, et al. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proc Natl Acad Sci U S A. 2017;114:E961-E969 pubmed publisher
Cortes C, Veiga S, Almacellas E, Hernández Losa J, Ferreres J, Kozma S, et al. Effect of low doses of actinomycin D on neuroblastoma cell lines. Mol Cancer. 2016;15:1 pubmed publisher
Lainé A, Martin B, Luka M, Mir L, Auffray C, Lucas B, et al. Foxo1 Is a T Cell-Intrinsic Inhibitor of the RORγt-Th17 Program. J Immunol. 2015;195:1791-803 pubmed publisher
Tebbi A, Guittet O, Tuphile K, Cabrié A, Lepoivre M. Caspase-dependent Proteolysis of Human Ribonucleotide Reductase Small Subunits R2 and p53R2 during Apoptosis. J Biol Chem. 2015;290:14077-90 pubmed publisher
Lawlor K, Khan N, Mildenhall A, Gerlic M, Croker B, D Cruz A, et al. RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL. Nat Commun. 2015;6:6282 pubmed publisher
Bahrini I, Song J, Diez D, Hanayama R. Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia. Sci Rep. 2015;5:7989 pubmed publisher
Liu Y, Clegg H, Leslie P, Di J, Tollini L, He Y, et al. CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation. Cell Death Differ. 2015;22:1035-46 pubmed publisher
Valenzuela M, Glorieux C, Stockis J, Sid B, Sandoval J, Felipe K, et al. Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells. Br J Cancer. 2014;111:874-82 pubmed publisher
Baracho G, Cato M, Zhu Z, Jaren O, Hobeika E, Reth M, et al. PDK1 regulates B cell differentiation and homeostasis. Proc Natl Acad Sci U S A. 2014;111:9573-8 pubmed publisher
Greenlee Wacker M, Rigby K, Kobayashi S, Porter A, Deleo F, Nauseef W. Phagocytosis of Staphylococcus aureus by human neutrophils prevents macrophage efferocytosis and induces programmed necrosis. J Immunol. 2014;192:4709-17 pubmed publisher
Galan Moya E, Treps L, Oliver L, Chneiweiss H, Vallette F, Bidere N, et al. Endothelial secreted factors suppress mitogen deprivation-induced autophagy and apoptosis in glioblastoma stem-like cells. PLoS ONE. 2014;9:e93505 pubmed publisher
Yamaguchi H, Maruyama T, Urade Y, Nagata S. Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells. elife. 2014;3:e02172 pubmed publisher
El Khoury V, Pierson S, Szwarcbart E, Brons N, Roland O, Cherrier De Wilde S, et al. Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia. Leukemia. 2014;28:1636-46 pubmed publisher
Lucas C, Dorward D, Tait M, Fox S, Marwick J, Allen K, et al. Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung. Mucosal Immunol. 2014;7:857-68 pubmed publisher
Liu X, Cohen J. Inhibition of Bim enhances replication of varicella-zoster virus and delays plaque formation in virus-infected cells. J Virol. 2014;88:1381-8 pubmed publisher
Colacurcio D, Yeager A, Kolson D, Jordan Sciutto K, Akay C. Calpain-mediated degradation of MDMx/MDM4 contributes to HIV-induced neuronal damage. Mol Cell Neurosci. 2013;57:54-62 pubmed publisher
Murphy J, Czabotar P, Hildebrand J, Lucet I, Zhang J, Alvarez Diaz S, et al. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity. 2013;39:443-53 pubmed publisher
Suzuki J, Fujii T, Imao T, Ishihara K, Kuba H, Nagata S. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem. 2013;288:13305-16 pubmed publisher
Bertin Ciftci J, Barre B, Le Pen J, Maillet L, Couriaud C, Juin P, et al. pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737. Cell Death Differ. 2013;20:755-64 pubmed publisher
Jak M, van Bochove G, Reits E, Kallemeijn W, Tromp J, Umana P, et al. CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101. Blood. 2011;118:5178-88 pubmed publisher
Jones J, Phuah C, Cox A, Thompson S, Ban M, Shawcross J, et al. IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). J Clin Invest. 2009;119:2052-61 pubmed publisher
Son K, Becker R, Kallio P, Lipton H. Theiler's virus-induced intrinsic apoptosis in M1-D macrophages is Bax mediated and restricts virus infectivity: a mechanism for persistence of a cytolytic virus. J Virol. 2008;82:4502-10 pubmed publisher
Petit I, Karajannis M, Vincent L, Young L, Butler J, Hooper A, et al. The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death. Blood. 2008;111:1951-61 pubmed
product information
master code :
OPH001
SKU :
OPH001-01M
product name :
Pan Caspase OPH Inhibitor Q-VD, Non-omethylated
unit size :
1 mg
target :
Caspase (Pan-specific)
category :
Peptides
species :
Multi-Species
USD :
236 USD
alt names :
CASP1, caspase 1, ICE, IL1BC, p45
storage :
Store the unopened product at -20 to -70 ░C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.