This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Mouse TRANCE/RANK L/TNFSF11 Quantikine ELISA Kit
catalog :
MTR00
quantity :
1 Kit
price :
655 USD
citations: 68
Reference
Uehara N, Shibusawa N, Mikami Y, Kyumoto Nakamura Y, Sonoda S, Kato H, et al. Bone metastatic mammary tumor cell-derived extracellular vesicles inhibit osteoblast maturation via JNK signaling. Arch Biochem Biophys. 2023;750:109821 pubmed publisher
Miyagawa K, Tenshin H, Mulcrone P, Delgado Calle J, Subler M, Windle J, et al. Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation. JCI Insight. 2023;8: pubmed publisher
Gao X, Sun X, Cheng H, Ruzbarsky J, Mullen M, Huard M, et al. MRL/MpJ Mice Resist to Age-Related and Long-Term Ovariectomy-Induced Bone Loss: Implications for Bone Regeneration and Repair. Int J Mol Sci. 2023;24: pubmed publisher
Polan C, Brenner C, Herten M, Hilken G, Grabellus F, Meyer H, et al. Increased UHMWPE Particle-Induced Osteolysis in Fetuin-A-Deficient Mice. J Funct Biomater. 2023;14: pubmed publisher
Li Z, Bowers E, Zhu J, Yu H, Hardij J, Bagchi D, et al. Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits. elife. 2022;11: pubmed publisher
Kim J, Yang Y, Xie J, Lee O, Kim J, Hong J, et al. Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes. Cell Death Differ. 2022;: pubmed publisher
Junqueira J, Louren xe7 o J, da Silva K, Jorgetti V, Vieira R, de Araujo A, et al. Increased bone resorption by long-term cigarette smoke exposure in animal model. Heliyon. 2021;7:e08587 pubmed publisher
Zhao W, Wiedemann P, Wölfel E, Neven M, Peters S, Imhof T, et al. Decreased Trabecular Bone Mass in Col22a1-Deficient Mice. Cells. 2021;10: pubmed publisher
Liao N, Koehne T, Tuckermann J, Triviai I, Amling M, David J, et al. Osteoblast-specific inactivation of p53 results in locally increased bone formation. PLoS ONE. 2021;16:e0249894 pubmed publisher
Lee E, Na W, Kang M, Kim Y, Kim D, Oh H, et al. Hydroxycoumarin Scopoletin Inhibits Bone Loss through Enhancing Induction of Bone Turnover Markers in a Mouse Model of Type 2 Diabetes. Biomedicines. 2021;9: pubmed publisher
MacLeod R, Meyer M, Xiong J, Cawley K, Liu Y, Onal M, et al. Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo. PLoS ONE. 2021;16:e0250974 pubmed publisher
Timmen M, Hidding H, G xf6 tte M, Khassawna T, Kronenberg D, Stange R. The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis. Sci Rep. 2020;10:20510 pubmed publisher
Cawley K, Bustamante Gomez N, Guha A, MacLeod R, Xiong J, Gubrij I, et al. Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption. Cell Rep. 2020;32:108052 pubmed publisher
Kato S, Tanabe N, Nagao M, Sekino J, Tomita K, Sakai M, et al. Glucose transporter 4 mediates LPS-induced IL-6 production in osteoblasts under high glucose conditions. J Oral Sci. 2020;62:423-426 pubmed publisher
Koide M, Yamashita T, Murakami K, Uehara S, Nakamura K, Nakamura M, et al. Sclerostin expression in trabecular bone is downregulated by osteoclasts. Sci Rep. 2020;10:13751 pubmed publisher
Velletri T, Huang Y, Wang Y, Li Q, Hu M, Xie N, et al. Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin. Cell Death Differ. 2021;28:156-169 pubmed publisher
Sahbani K, Cardozo C, Bauman W, TAWFEEK H. Abaloparatide exhibits greater osteoanabolic response and higher cAMP stimulation and β-arrestin recruitment than teriparatide. Physiol Rep. 2019;7:e14225 pubmed publisher
Heckt T, Brylka L, Neven M, Amling M, Schinke T. Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase. PLoS ONE. 2019;14:e0219734 pubmed publisher
Wauquier F, Daneault A, Granel H, Prawitt J, Fabien Soulé V, Berger J, et al. Human Enriched Serum Following Hydrolysed Collagen Absorption Modulates Bone Cell Activity: from Bedside to Bench and Vice Versa. Nutrients. 2019;11: pubmed publisher
Gao X, Lu A, Tang Y, Schneppendahl J, Liebowitz A, Scibetta A, et al. Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration. Stem Cell Res Ther. 2018;9:316 pubmed publisher
Ikebuchi Y, Aoki S, Honma M, Hayashi M, Sugamori Y, Khan M, et al. Coupling of bone resorption and formation by RANKL reverse signalling. Nature. 2018;561:195-200 pubmed publisher
Zimmerman S, Heard Lipsmeyer M, Dimori M, Thostenson J, Mannen E, O Brien C, et al. Loss of RANKL in osteocytes dramatically increases cancellous bone mass in the osteogenesis imperfecta mouse (oim). Bone Rep. 2018;9:61-73 pubmed publisher
Xiong J, Cawley K, Piemontese M, Fujiwara Y, Zhao H, Goellner J, et al. Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss. Nat Commun. 2018;9:2909 pubmed publisher
Cheung L, Tickner J, Hughes A, Skut P, Howlett M, Foley B, et al. New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment. Leukemia. 2018;32:2326-2338 pubmed publisher
Lee N, Clarke I, Enriquez R, Nagy V, Penninger J, Baldock P, et al. Central RANK signalling in NPY neurons alters bone mass in male mice. Neuropeptides. 2018;68:75-83 pubmed publisher
Yang N, Baban B, Isales C, Shi X. Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss. PLoS ONE. 2017;12:e0181133 pubmed publisher
Park O, Kim J, Yang J, Yun C, Han S. Muramyl Dipeptide, a Shared Structural Motif of Peptidoglycans, Is a Novel Inducer of Bone Formation through Induction of Runx2. J Bone Miner Res. 2017;32:1455-1468 pubmed publisher
Davis H, Pacheco Costa R, Atkinson E, Brun L, Gortazar A, Harris J, et al. Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging. Aging Cell. 2017;16:551-563 pubmed publisher
Pezzotti G, McEntire B, Bock R, Boffelli M, Zhu W, Vitale E, et al. Silicon Nitride: A Synthetic Mineral for Vertebrate Biology. Sci Rep. 2016;6:31717 pubmed publisher
Kassem A, Henning P, Lundberg P, Souza P, Lindholm C, Lerner U. Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-κB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts. J Biol Chem. 2015;290:20147-58 pubmed publisher
Yang Y, Blair H, Shapiro I, Wang B. The Proteasome Inhibitor Carfilzomib Suppresses Parathyroid Hormone-induced Osteoclastogenesis through a RANKL-mediated Signaling Pathway. J Biol Chem. 2015;290:16918-28 pubmed publisher
Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, et al. 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival. J Biol Chem. 2015;290:9377-86 pubmed publisher
Nollet M, Santucci Darmanin S, Breuil V, Al Sahlanee R, Cros C, Topi M, et al. Autophagy in osteoblasts is involved in mineralization and bone homeostasis. Autophagy. 2014;10:1965-77 pubmed publisher
Onal M, Bishop K, St John H, Danielson A, Riley E, Piemontese M, et al. A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse. J Bone Miner Res. 2015;30:855-68 pubmed publisher
Baek J, Kim J, Cheon Y, Park S, Ahn S, Yoon K, et al. Aconitum pseudo-laeve var. erectum inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis via the c-Fos/nuclear factor of activated T-cells, cytoplasmic 1 signaling pathway and prevents lipopolysaccharide-induced bone. Molecules. 2014;19:11628-44 pubmed publisher
Teufel S, Grötsch B, Luther J, Derer A, Schinke T, Amling M, et al. Inhibition of bone remodeling in young mice by bisphosphonate displaces the plasma cell niche into the spleen. J Immunol. 2014;193:223-33 pubmed publisher
Yoo Y, Kwag J, Kim K, Kim C. Effects of neuropeptides and mechanical loading on bone cell resorption in vitro. Int J Mol Sci. 2014;15:5874-83 pubmed publisher
Mosti M, Stunes A, Ericsson M, Pullisaar H, Reseland J, Shabestari M, et al. Effects of the peroxisome proliferator-activated receptor (PPAR)-δ agonist GW501516 on bone and muscle in ovariectomized rats. Endocrinology. 2014;155:2178-89 pubmed publisher
Ohba T, Cole H, Cates J, Slosky D, Haro H, Ando T, et al. Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL. J Bone Miner Res. 2014;29:1431-45 pubmed publisher
Teramachi J, Zhou H, Subler M, Kitagawa Y, Galson D, Dempster D, et al. Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone. J Bone Miner Res. 2014;29:1456-65 pubmed publisher
Gruenwald K, Castagnola P, Besio R, Dimori M, Chen Y, Akel N, et al. Sc65 is a novel endoplasmic reticulum protein that regulates bone mass homeostasis. J Bone Miner Res. 2014;29:666-75 pubmed publisher
Gao L, Faibish D, Fredman G, Herrera B, Chiang N, Serhan C, et al. Resolvin E1 and chemokine-like receptor 1 mediate bone preservation. J Immunol. 2013;190:689-94 pubmed publisher
Buckle C, De Leenheer E, Lawson M, Yong K, Rabin N, Perry M, et al. Soluble rank ligand produced by myeloma cells causes generalised bone loss in multiple myeloma. PLoS ONE. 2012;7:e41127 pubmed publisher
Onal M, Xiong J, Chen X, Thostenson J, Almeida M, Manolagas S, et al. Receptor activator of nuclear factor ?B ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 2012;287:29851-60 pubmed publisher
Hayashi M, Nakashima T, Taniguchi M, Kodama T, Kumanogoh A, Takayanagi H. Osteoprotection by semaphorin 3A. Nature. 2012;485:69-74 pubmed publisher
Ma B, Zhang Q, Wu D, Wang Y, Hu Y, Cheng Y, et al. Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway. Acta Pharmacol Sin. 2012;33:479-89 pubmed publisher
Onal M, Galli C, Fu Q, Xiong J, Weinstein R, Manolagas S, et al. The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice. Mol Endocrinol. 2012;26:341-8 pubmed publisher
Chao C, Joyce Shaikh B, Grein J, Moshrefi M, Raoufi F, LaFace D, et al. C17 prevents inflammatory arthritis and associated joint destruction in mice. PLoS ONE. 2011;6:e22256 pubmed publisher
Rufo A, Del Fattore A, Capulli M, Carvello F, De Pasquale L, Ferrari S, et al. Mechanisms inducing low bone density in Duchenne muscular dystrophy in mice and humans. J Bone Miner Res. 2011;26:1891-903 pubmed publisher
Mentrup B, Marschall C, Barvencik F, Amling M, Plendl H, Jakob F, et al. Functional characterization of a novel mutation localized in the start codon of the tissue-nonspecific alkaline phosphatase gene. Bone. 2011;48:1401-8 pubmed publisher
Ho T, Santora K, Chen J, Frankshun A, Bagnell C. Effects of relaxin and estrogens on bone remodeling markers, receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG), in rat adjuvant-induced arthritis. Bone. 2011;48:1346-53 pubmed publisher
Sample S, Collins R, Wilson A, Racette M, Behan M, Markel M, et al. Systemic effects of ulna loading in male rats during functional adaptation. J Bone Miner Res. 2010;25:2016-28 pubmed publisher
Neunaber C, Catala Lehnen P, Beil F, Marshall R, Kanbach V, Baranowsky A, et al. Increased trabecular bone formation in mice lacking the growth factor midkine. J Bone Miner Res. 2010;25:1724-35 pubmed publisher
Sauer A, Mrak E, Hernandez R, Zacchi E, Cavani F, Casiraghi M, et al. ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency. Blood. 2009;114:3216-26 pubmed publisher
O Connor R, Zayzafoon M, Farach Carson M, Schanen N. Mecp2 deficiency decreases bone formation and reduces bone volume in a rodent model of Rett syndrome. Bone. 2009;45:346-56 pubmed publisher
Wang L, Zhao R, Shi X, Wei T, Halloran B, Clark D, et al. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone. 2009;45:309-20 pubmed publisher
Pierroz D, Rufo A, Bianchi E, Glatt V, Capulli M, Rucci N, et al. Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice. J Bone Miner Res. 2009;24:775-84 pubmed publisher
Valverde P, Zhang J, Fix A, Zhu J, Ma W, Tu Q, et al. Overexpression of bone sialoprotein leads to an uncoupling of bone formation and bone resorption in mice. J Bone Miner Res. 2008;23:1775-88 pubmed publisher
Garlet G, Cardoso C, Campanelli A, Garlet T, Avila Campos M, Cunha F, et al. The essential role of IFN-gamma in the control of lethal Aggregatibacter actinomycetemcomitans infection in mice. Microbes Infect. 2008;10:489-96 pubmed publisher
Liu J, Xu K, Wen G, Guo H, Li S, Wu X, et al. Comparison of the effects of genistein and zoledronic acid on the bone loss in OPG-deficient mice. Bone. 2008;42:950-9 pubmed publisher
Qiang Y, Chen Y, Stephens O, Brown N, Chen B, Epstein J, et al. Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood. 2008;112:196-207 pubmed publisher
Morony S, Tintut Y, Zhang Z, Cattley R, Van G, Dwyer D, et al. Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice. Circulation. 2008;117:411-20 pubmed publisher
Niki Y, Takaishi H, Takito J, Miyamoto T, Kosaki N, Matsumoto H, et al. Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction. J Immunol. 2007;179:639-46 pubmed
Brechter A, Lerner U. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. Arthritis Rheum. 2007;56:910-23 pubmed
Li Y, Toraldo G, Li A, Yang X, Zhang H, Qian W, et al. B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood. 2007;109:3839-48 pubmed
Nakamichi Y, Udagawa N, Kobayashi Y, Nakamura M, Yamamoto Y, Yamashita T, et al. Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts. J Immunol. 2007;178:192-200 pubmed
Tang C, Hsu T, Lin W, Lai M, Yang R, Hsieh S, et al. Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice. J Biol Chem. 2007;282:2346-54 pubmed
Sato M, Nakamichi Y, Nakamura M, Sato N, Ninomiya T, Muto A, et al. New 19-nor-(20S)-1alpha,25-dihydroxyvitamin D3 analogs strongly stimulate osteoclast formation both in vivo and in vitro. Bone. 2007;40:293-304 pubmed
product information
master code :
MTR00
SKU :
MTR00
product name :
Mouse TRANCE/RANK L/TNFSF11 Quantikine ELISA Kit
unit size :
1 Kit
description :
The Mouse TRANCE/RANK L/TNFSF11 Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies mouse TRANCE/TNFSF11/RANK L in cell culture supernates (50 ul), serum (25 ul).
target :
TRANCE/TNFSF11/RANK L
category :
ELISAs
species :
Mouse
specificity :
Free natural and recombinant mouse TRANCE
gene symbol :
Tnfsf11
kit type :
Solid Phase Sandwich ELISA
assay length :
4.5 hours
elisaSampleTypes :
Cell Culture Supernates (50 uL), Serum (25 uL)
elisaSensitivity :
5 pg/mL
elisaRange :
31.20 - 2000 pg/mL
top caption :
Mouse TRANCE/TNFSF11/RANK L ELISA Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Mouse TRANCE Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse TRANCE in cell culture supernates and serum. It contains NS0-expressed recombinant mouse TRANCE and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant mouse TRANCE accurately. Results obtained using natural mouse TRANCE showed dose response curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse TRANCE.
alt names :
CD254, CD254 antigen, ODF, OPGL, OPGLOPTB2, Osteoclast differentiation factor, Osteoprotegerin ligand, RANK L, RANKL, RANKLreceptor activator of nuclear factor kappa B ligand, Receptor activator of nuclear factor kappa-B ligand, sOdf, TNF-related activation-induced cytokine, TNFSF11, TRANCEODFhRANKL2, tumor necrosis factor (ligand) superfamily, member 11, tumor necrosis factor ligand superfamily member 11
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.