This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Mouse Proprotein Convertase 9/PCSK9 Quantikine ELISA Kit
catalog :
MPC900
quantity :
1 Kit
price :
655 USD
citations: 30
Reference
Cappelluti M, Mollica Poeta V, Valsoni S, Quarato P, Merlin S, Merelli I, et al. Durable and efficient gene silencing in vivo by hit-and-run epigenome editing. Nature. 2024;627:416-423 pubmed publisher
Franko N, da Silva Santinha A, Xue S, Zhao H, Charpin El Hamri G, Platt R, et al. Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo. Cell Discov. 2024;10:9 pubmed publisher
Han W, Gao B, Zhu J, He Z, Li J, Yang L, et al. Design and application of the transformer base editor in mammalian cells and mice. Nat Protoc. 2023;18:3194-3228 pubmed publisher
Schmidheini L, Mathis N, Marquart K, Rothgangl T, Kissling L, B xf6 ck D, et al. Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility. Nat Chem Biol. 2023;: pubmed publisher
Bestas B, Wimberger S, Degtev D, Madsen A, Rottner A, Karlsson F, et al. A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo. Nat Commun. 2023;14:5474 pubmed publisher
Goks xf8 yr L, Skrzypczak M, Sampson M, Nielsen M, Salanti A, Theander T, et al. A cVLP-Based Vaccine Displaying Full-Length PCSK9 Elicits a Higher Reduction in Plasma PCSK9 Than Similar Peptide-Based cVLP Vaccines. Vaccines (Basel). 2022;11: pubmed publisher
Pakalni x161 kyt x117 D, Sch xf6 nberger T, Strobel B, Stierstorfer B, Lamla T, Schuler M, et al. Rosa26-LSL-dCas9-VPR: a versatile mouse model for tissue specific and simultaneous activation of multiple genes for drug discovery. Sci Rep. 2022;12:19268 pubmed publisher
Stomberski C, Venetos N, Zhou H, Qian Z, Collison B, Field S, et al. A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis. Cell Rep. 2022;41:111538 pubmed publisher
Chen P, Tseng S, Chang H, Lee C, Chao T. Diverse Effects of Cilostazol on Proprotein Convertase Subtilisin/Kexin Type 9 between Obesity and Non-Obesity. Int J Mol Sci. 2022;23: pubmed publisher
Tong H, Huang J, Xiao Q, He B, Dong X, Liu Y, et al. High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects. Nat Biotechnol. 2022;: pubmed publisher
Lebeau P, Byun J, Platko K, Saliba P, Sguazzin M, Macdonald M, et al. Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance. Nat Commun. 2022;13:770 pubmed publisher
Deshycka R, Sudaryo V, Huang N, Xie Y, Smeding L, Choi M, et al. Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity. PLoS ONE. 2021;16:e0259353 pubmed publisher
Rothgangl T, Dennis M, Lin P, Oka R, Witzigmann D, Villiger L, et al. In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels. Nat Biotechnol. 2021;39:949-957 pubmed publisher
Wang L, Xue W, Zhang H, Gao R, Qiu H, Wei J, et al. Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations. Nat Cell Biol. 2021;23:552-563 pubmed publisher
Ibold B, Tiemann J, Faust I, Ceglarek U, Dittrich J, Gorgels T, et al. Genetic deletion of Abcc6 disturbs cholesterol homeostasis in mice. Sci Rep. 2021;11:2137 pubmed publisher
Backstrom J, Sheng J, Wang M, Bernardo Colón A, Rex T. Optimization of S. aureus dCas9 and CRISPRi Elements for a Single Adeno-Associated Virus that Targets an Endogenous Gene. Mol Ther Methods Clin Dev. 2020;19:139-148 pubmed publisher
Moghadam F, LeGraw R, Velazquez J, Yeo N, Xu C, Park J, et al. Synthetic immunomodulation with a CRISPR super-repressor in vivo. Nat Cell Biol. 2020;22:1143-1154 pubmed publisher
Carreras A, Pane L, Nitsch R, Madeyski Bengtson K, Porritt M, Akçakaya P, et al. In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model. BMC Biol. 2019;17:4 pubmed publisher
Rossidis A, Stratigis J, Chadwick A, Hartman H, Ahn N, Li H, et al. In utero CRISPR-mediated therapeutic editing of metabolic genes. Nat Med. 2018;24:1513-1518 pubmed publisher
Akçakaya P, Bobbin M, Guo J, Malagon Lopez J, Clement K, Garcia S, et al. In vivo CRISPR editing with no detectable genome-wide off-target mutations. Nature. 2018;561:416-419 pubmed publisher
Thakore P, Kwon J, Nelson C, Rouse D, Gemberling M, Oliver M, et al. RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors. Nat Commun. 2018;9:1674 pubmed publisher
Chadwick A, Evitt N, Lv W, Musunuru K. Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3. Circulation. 2018;137:975-977 pubmed publisher
Masuda Y, Yamaguchi S, Suzuki C, Aburatani T, Nagano Y, Miyauchi R, et al. Generation and Characterization of a Novel Small Biologic Alternative to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Antibodies, DS-9001a, Albumin Binding Domain-Fused Anticalin Protein. J Pharmacol Exp Ther. 2018;365:368-378 pubmed publisher
Kawakami R, Nozato Y, Nakagami H, Ikeda Y, Shimamura M, Yoshida S, et al. Development of vaccine for dyslipidemia targeted to a proprotein convertase subtilisin/kexin type 9 (PCSK9) epitope in mice. PLoS ONE. 2018;13:e0191895 pubmed publisher
Rogers M, Maldonado N, Hutcheson J, Goettsch C, Goto S, Yamada I, et al. Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress. Circ Res. 2017;121:220-233 pubmed publisher
Dong B, Young M, Liu X, Singh A, Liu J. Regulation of lipid metabolism by obeticholic acid in hyperlipidemic hamsters. J Lipid Res. 2017;58:350-363 pubmed publisher
Lebeau P, Al Hashimi A, Sood S, Lhotak S, Yu P, Gyulay G, et al. Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism. J Biol Chem. 2017;292:1510-1523 pubmed publisher
Shende V, Wu M, Singh A, Dong B, Kan C, Liu J. Reduction of circulating PCSK9 and LDL-C levels by liver-specific knockdown of HNF1α in normolipidemic mice. J Lipid Res. 2015;56:801-9 pubmed publisher
Dong B, Li H, Singh A, Cao A, Liu J. Inhibition of PCSK9 transcription by berberine involves down-regulation of hepatic HNF1α protein expression through the ubiquitin-proteasome degradation pathway. J Biol Chem. 2015;290:4047-58 pubmed publisher
Ding Q, Strong A, Patel K, Ng S, Gosis B, Regan S, et al. Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing. Circ Res. 2014;115:488-92 pubmed publisher
product information
master code :
MPC900
SKU :
MPC900
product name :
Mouse Proprotein Convertase 9/PCSK9 Quantikine ELISA Kit
unit size :
1 Kit
description :
The Mouse Proprotein Convertase 9/PCSK9 Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies mouse Proprotein Convertase 9/PCSK9 in cell culture supernates (50 ul), cell lysates (10 ul), serum (10 ul), edta plasma (10 ul), heparin plasma (10 ul).
target :
Proprotein Convertase 9/PCSK9
category :
ELISAs
species :
Mouse
specificity :
Natural and recombinant mouse PCSK9. This kit detects 60 kDa, 53 kDa, and LDLR-complexed recombinant mouse PCSK9.
gene symbol :
Pcsk9
kit type :
Solid Phase Sandwich ELISA
assay length :
4.5 hours
elisaSampleTypes :
Cell Culture Supernates (50 uL), Cell Lysates (10 uL), Serum (10 uL), EDTA Plasma (10 uL), Heparin Plasma (10 uL)
elisaSensitivity :
21.9 pg/mL
elisaRange :
62.50 - 4000 pg/mL
top caption :
Mouse Proprotein Convertase 9/PCSK9 ELISA Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Mouse PCSK9 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse PCSK9 in cell culture supernates, cell lysates, serum, and plasma. It contains NS0-expressed recombinant mouse PCSK9 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural mouse PCSK9 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring mouse PCSK9.
alt names :
EC 3.4.21, EC 3.4.21.111, FH3, FH3neural apoptosis regulated convertase 1, FHCL3, HCHOLA3, hypercholesterolemia, autosomal dominant 3, LDLCQ1, NARC1, NARC-1, NARC-1convertase subtilisin/kexin type 9 preproprotein, NARC1EC 3.4.21.-, Neural apoptosis-regulated convertase 1, PC9, PCSK9, Proprotein convertase 9, proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.