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company name :
R&D Systems
product type :
ELISA/assay
product name :
Mouse Osteoprotegerin/TNFRSF11B Quantikine ELISA Kit
catalog :
MOP00
quantity :
1 Kit
price :
655 USD
more info or order :
citations: 57
Reference
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Yong J, Gr xf6 ger S, von Bremen J, Ruf S. Ciliary Neurotrophic Factor (CNTF) Inhibits In Vitro Cementoblast Mineralization and Induces Autophagy, in Part by STAT3/ERK Commitment. Int J Mol Sci. 2022;23: pubmed publisher
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Zhao W, Wiedemann P, Wölfel E, Neven M, Peters S, Imhof T, et al. Decreased Trabecular Bone Mass in Col22a1-Deficient Mice. Cells. 2021;10: pubmed publisher
Liao N, Koehne T, Tuckermann J, Triviai I, Amling M, David J, et al. Osteoblast-specific inactivation of p53 results in locally increased bone formation. PLoS ONE. 2021;16:e0249894 pubmed publisher
Lee E, Na W, Kang M, Kim Y, Kim D, Oh H, et al. Hydroxycoumarin Scopoletin Inhibits Bone Loss through Enhancing Induction of Bone Turnover Markers in a Mouse Model of Type 2 Diabetes. Biomedicines. 2021;9: pubmed publisher
Li W, Wei C, Xu L, Yu B, Chen Y, Lu D, et al. Schistosome infection promotes osteoclast-mediated bone loss. PLoS Pathog. 2021;17:e1009462 pubmed publisher
Timmen M, Hidding H, G xf6 tte M, Khassawna T, Kronenberg D, Stange R. The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis. Sci Rep. 2020;10:20510 pubmed publisher
Hannappe M, Arnould L, Meloux A, Mouhat B, Bichat F, Zeller M, et al. Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients. Sci Rep. 2020;10:16718 pubmed publisher
Cawley K, Bustamante Gomez N, Guha A, MacLeod R, Xiong J, Gubrij I, et al. Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption. Cell Rep. 2020;32:108052 pubmed publisher
Tsukasaki M, Asano T, Muro R, Huynh N, Komatsu N, Okamoto K, et al. OPG Production Matters Where It Happened. Cell Rep. 2020;32:108124 pubmed publisher
Velletri T, Huang Y, Wang Y, Li Q, Hu M, Xie N, et al. Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin. Cell Death Differ. 2021;28:156-169 pubmed publisher
Sahbani K, Cardozo C, Bauman W, TAWFEEK H. Abaloparatide exhibits greater osteoanabolic response and higher cAMP stimulation and β-arrestin recruitment than teriparatide. Physiol Rep. 2019;7:e14225 pubmed publisher
Heckt T, Brylka L, Neven M, Amling M, Schinke T. Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase. PLoS ONE. 2019;14:e0219734 pubmed publisher
Kang J, Choi Y, Seo B, Jo U, Park S, Kim Y, et al. A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment. Sci Rep. 2019;9:8726 pubmed publisher
Pesaro A, Katz M, Liberman M, Pereira C, Mangueira C, de Carvalho A, et al. Circulating osteogenic proteins are associated with coronary artery calcification and increase after myocardial infarction. PLoS ONE. 2018;13:e0202738 pubmed publisher
Zimmerman S, Heard Lipsmeyer M, Dimori M, Thostenson J, Mannen E, O Brien C, et al. Loss of RANKL in osteocytes dramatically increases cancellous bone mass in the osteogenesis imperfecta mouse (oim). Bone Rep. 2018;9:61-73 pubmed publisher
Xiong J, Cawley K, Piemontese M, Fujiwara Y, Zhao H, Goellner J, et al. Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss. Nat Commun. 2018;9:2909 pubmed publisher
Lee N, Clarke I, Enriquez R, Nagy V, Penninger J, Baldock P, et al. Central RANK signalling in NPY neurons alters bone mass in male mice. Neuropeptides. 2018;68:75-83 pubmed publisher
Yang N, Baban B, Isales C, Shi X. Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss. PLoS ONE. 2017;12:e0181133 pubmed publisher
Hulley P, Bishop T, Vernet A, Schneider J, Edwards J, Athanasou N, et al. Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2. J Pathol. 2017;242:322-333 pubmed publisher
Park O, Kim J, Yang J, Yun C, Han S. Muramyl Dipeptide, a Shared Structural Motif of Peptidoglycans, Is a Novel Inducer of Bone Formation through Induction of Runx2. J Bone Miner Res. 2017;32:1455-1468 pubmed publisher
Davis H, Pacheco Costa R, Atkinson E, Brun L, Gortazar A, Harris J, et al. Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging. Aging Cell. 2017;16:551-563 pubmed publisher
Pezzotti G, McEntire B, Bock R, Boffelli M, Zhu W, Vitale E, et al. Silicon Nitride: A Synthetic Mineral for Vertebrate Biology. Sci Rep. 2016;6:31717 pubmed publisher
Iyer S, Han L, Ambrogini E, Yavropoulou M, Fowlkes J, Manolagas S, et al. Deletion of FoxO1, 3, and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes. J Bone Miner Res. 2017;32:60-69 pubmed publisher
Kassem A, Henning P, Lundberg P, Souza P, Lindholm C, Lerner U. Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-κB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts. J Biol Chem. 2015;290:20147-58 pubmed publisher
Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, et al. 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival. J Biol Chem. 2015;290:9377-86 pubmed publisher
Baek J, Kim J, Cheon Y, Park S, Ahn S, Yoon K, et al. Aconitum pseudo-laeve var. erectum inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis via the c-Fos/nuclear factor of activated T-cells, cytoplasmic 1 signaling pathway and prevents lipopolysaccharide-induced bone. Molecules. 2014;19:11628-44 pubmed publisher
Teufel S, Grötsch B, Luther J, Derer A, Schinke T, Amling M, et al. Inhibition of bone remodeling in young mice by bisphosphonate displaces the plasma cell niche into the spleen. J Immunol. 2014;193:223-33 pubmed publisher
Yoo Y, Kwag J, Kim K, Kim C. Effects of neuropeptides and mechanical loading on bone cell resorption in vitro. Int J Mol Sci. 2014;15:5874-83 pubmed publisher
Hayashida C, Ito J, Nakayachi M, Okayasu M, Ohyama Y, Hakeda Y, et al. Osteocytes produce interferon-β as a negative regulator of osteoclastogenesis. J Biol Chem. 2014;289:11545-55 pubmed publisher
Ohba T, Cole H, Cates J, Slosky D, Haro H, Ando T, et al. Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL. J Bone Miner Res. 2014;29:1431-45 pubmed publisher
Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, et al. Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5). J Bone Miner Res. 2013;28:2070-80 pubmed publisher
Gao L, Faibish D, Fredman G, Herrera B, Chiang N, Serhan C, et al. Resolvin E1 and chemokine-like receptor 1 mediate bone preservation. J Immunol. 2013;190:689-94 pubmed publisher
Buckle C, De Leenheer E, Lawson M, Yong K, Rabin N, Perry M, et al. Soluble rank ligand produced by myeloma cells causes generalised bone loss in multiple myeloma. PLoS ONE. 2012;7:e41127 pubmed publisher
Hayashi M, Nakashima T, Taniguchi M, Kodama T, Kumanogoh A, Takayanagi H. Osteoprotection by semaphorin 3A. Nature. 2012;485:69-74 pubmed publisher
Ma B, Zhang Q, Wu D, Wang Y, Hu Y, Cheng Y, et al. Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway. Acta Pharmacol Sin. 2012;33:479-89 pubmed publisher
Onal M, Galli C, Fu Q, Xiong J, Weinstein R, Manolagas S, et al. The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice. Mol Endocrinol. 2012;26:341-8 pubmed publisher
Ho T, Santora K, Chen J, Frankshun A, Bagnell C. Effects of relaxin and estrogens on bone remodeling markers, receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG), in rat adjuvant-induced arthritis. Bone. 2011;48:1346-53 pubmed publisher
Sample S, Collins R, Wilson A, Racette M, Behan M, Markel M, et al. Systemic effects of ulna loading in male rats during functional adaptation. J Bone Miner Res. 2010;25:2016-28 pubmed publisher
Neunaber C, Catala Lehnen P, Beil F, Marshall R, Kanbach V, Baranowsky A, et al. Increased trabecular bone formation in mice lacking the growth factor midkine. J Bone Miner Res. 2010;25:1724-35 pubmed publisher
Sauer A, Mrak E, Hernandez R, Zacchi E, Cavani F, Casiraghi M, et al. ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency. Blood. 2009;114:3216-26 pubmed publisher
O Connor R, Zayzafoon M, Farach Carson M, Schanen N. Mecp2 deficiency decreases bone formation and reduces bone volume in a rodent model of Rett syndrome. Bone. 2009;45:346-56 pubmed publisher
Pierroz D, Rufo A, Bianchi E, Glatt V, Capulli M, Rucci N, et al. Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice. J Bone Miner Res. 2009;24:775-84 pubmed publisher
Qiang Y, Chen Y, Stephens O, Brown N, Chen B, Epstein J, et al. Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood. 2008;112:196-207 pubmed publisher
Morony S, Tintut Y, Zhang Z, Cattley R, Van G, Dwyer D, et al. Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice. Circulation. 2008;117:411-20 pubmed publisher
Secchiero P, Corallini F, Rimondi E, Chiaruttini C, di Iasio M, Rustighi A, et al. Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells. Blood. 2008;111:1287-94 pubmed
Zhu J, Jia X, Xiao G, Kang Y, Partridge N, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. J Biol Chem. 2007;282:26656-64 pubmed
Li Y, Toraldo G, Li A, Yang X, Zhang H, Qian W, et al. B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood. 2007;109:3839-48 pubmed
Nakamichi Y, Udagawa N, Kobayashi Y, Nakamura M, Yamamoto Y, Yamashita T, et al. Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts. J Immunol. 2007;178:192-200 pubmed
Berry J, Ealba E, Pettway G, Datta N, Swanson E, Somerman M, et al. JunB as a downstream mediator of PTHrP actions in cementoblasts. J Bone Miner Res. 2006;21:246-57 pubmed
Zehnder A, Kristiansen A, Adams J, Merchant S, McKenna M. Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsule. Laryngoscope. 2005;115:172-7 pubmed
Lubberts E, van den Bersselaar L, Oppers Walgreen B, Schwarzenberger P, Coenen de Roo C, Kolls J, et al. IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance. J Immunol. 2003;170:2655-62 pubmed
image
image 1 :
R&D Systems MOP00 image 1
Mouse Osteoprotegerin/TNFRSF11B ELISA Standard Curve
product information
master code :
MOP00
SKU :
MOP00
product name :
Mouse Osteoprotegerin/TNFRSF11B Quantikine ELISA Kit
unit size :
1 Kit
description :
The Mouse Osteoprotegerin/TNFRSF11B Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies mouse Osteoprotegerin/TNFRSF11B in cell culture supernates (50 ul), serum (10 ul), edta plasma (10 ul).
target :
Osteoprotegerin/TNFRSF11B
category :
ELISAs
species :
Mouse
specificity :
Natural and recombinant mouse OPG
gene symbol :
Tnfrsf11b
kit type :
Solid Phase Sandwich ELISA
assay length :
4.5 hours
elisaSampleTypes :
Cell Culture Supernates (50 uL), Serum (10 uL), EDTA Plasma (10 uL)
elisaSensitivity :
6.9 pg/mL
elisaRange :
31.30 - 2000 pg/mL
top caption :
Mouse Osteoprotegerin/TNFRSF11B ELISA Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Mouse OPG Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse OPG in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant mouse OPG and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant mouse OPG accurately. Results obtained using natural mouse OPG showed dose response curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse OPG.
alt names :
OCIF, OCIFMGC29565, OPG, OPGtumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, Osteoprotegerin, TNFRSF11B, TR1, tumor necrosis factor receptor superfamily, member 11b
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.