This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Leptin/OB ELISA
catalog :
MOB00
quantity :
1 Kit (2 Plates) (also 1 Pack (50 Plates), 1 Pack (6 Plates))
price :
659 USD
citations: 145
Reference
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Gil C, Ost M, Kasch J, Schumann S, Heider S, Klaus S. Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice. Sci Rep. 2019;9:20120 pubmed publisher
Kawao N, Ishida M, Kaji H. Roles of leptin in the recovery of muscle and bone by reloading after mechanical unloading in high fat diet-fed obese mice. PLoS ONE. 2019;14:e0224403 pubmed publisher
Siriarchavatana P, Kruger M, Miller M, Tian H, Wolber F. The Preventive Effects of Greenshell Mussel (Perna canaliculus) on Early-Stage Metabolic Osteoarthritis in Rats with Diet-Induced Obesity. Nutrients. 2019;11: pubmed publisher
Gougoula C, Bielfeld A, Pour S, Sager M, Krüssel J, Benten W, et al. Metabolic and behavioral parameters of mice with reduced expression of Syndecan-1. PLoS ONE. 2019;14:e0219604 pubmed publisher
Tazawa R, Uchida K, Fujimaki H, Miyagi M, Inoue G, Sekiguchi H, et al. Elevated leptin levels induce inflammation through IL-6 in skeletal muscle of aged female rats. BMC Musculoskelet Disord. 2019;20:199 pubmed publisher
Deis J, Guo H, Wu Y, Liu C, Bernlohr D, Chen X. Adipose Lipocalin 2 overexpression protects against age-related decline in thermogenic function of adipose tissue and metabolic deterioration. Mol Metab. 2019;24:18-29 pubmed publisher
Żebrowska E, Maciejczyk M, Zendzian Piotrowska M, Zalewska A, Chabowski A. High Protein Diet Induces Oxidative Stress in Rat Cerebral Cortex and Hypothalamus. Int J Mol Sci. 2019;20: pubmed publisher
Pierard M, Tassin A, Conotte S, Zouaoui Boudjeltia K, Legrand A. Sustained Intermittent Hypoxemia Induces Adiponectin Oligomers Redistribution and a Tissue-Specific Modulation of Adiponectin Receptor in Mice. Front Physiol. 2019;10:68 pubmed publisher
Bodur A, Ince I, Kahraman C, Abidin I, Aydin Abidin S, Alver A. Chronically reduced BDNF levels increase oxidative stress in epididymal, but not subcutaneous, adipose tissue following high sucrose and high fat diets fed mice. Arch Biochem Biophys. 2019;: pubmed publisher
Seo C, Yoo S, Jeong S, Ha H. Quantification of the constituents of the traditional Korea medicine, Samryeongbaekchul-san, and assessment of its antiadipogenic effect. Saudi Pharm J. 2019;27:145-153 pubmed publisher
Wang G, Mohammadtursun N, Lv Y, Zhang H, Sun J, Dong J. Baicalin Exerts Anti-Airway Inflammation and Anti-Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease. Evid Based Complement Alternat Med. 2018;2018:7591348 pubmed publisher
Kain D, Simon A, Greenberg A, Ben Zvi D, Gilburd B, Schneiderman J. Cardiac leptin overexpression in the context of acute MI and reperfusion potentiates myocardial remodeling and left ventricular dysfunction. PLoS ONE. 2018;13:e0203902 pubmed publisher
Mosqueda Solís A, SANCHEZ J, Reynés B, Palou M, Portillo M, Palou A, et al. Hesperidin and capsaicin, but not the combination, prevent hepatic steatosis and other metabolic syndrome-related alterations in western diet-fed rats. Sci Rep. 2018;8:15100 pubmed publisher
Philbrick K, Branscum A, Wong C, Turner R, Iwaniec U. Leptin Increases Particle-Induced Osteolysis in Female ob/ob Mice. Sci Rep. 2018;8:14790 pubmed publisher
Tazi A, Araújo J, Mulet C, Arena E, Nigro G, Pedron T, et al. Disentangling Host-Microbiota Regulation of Lipid Secretion by Enterocytes: Insights from Commensals Lactobacillus paracasei and Escherichia coli. MBio. 2018;9: pubmed publisher
Ravussin A, Youm Y, Sander J, Ryu S, Nguyen K, Varela L, et al. Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity. Cell Rep. 2018;24:1085-1092.e6 pubmed publisher
Deodati A, Argemi J, Germani D, Puglianiello A, Alisi A, De Stefanis C, et al. The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life. PLoS ONE. 2018;13:e0198490 pubmed publisher
Mastri M, Lee C, Tracz A, Kerbel R, Dolan M, Shi Y, et al. Tumor-Independent Host Secretomes Induced By Angiogenesis and Immune-Checkpoint Inhibitors. Mol Cancer Ther. 2018;17:1602-1612 pubmed publisher
Masarwi M, Shamir R, Phillip M, Gat Yablonski G. Leptin stimulates aromatase in the growth plate: limiting catch-up growth efficiency. J Endocrinol. 2018;237:229-242 pubmed publisher
Pan F, Zhang L, Li M, Hu Y, Zeng B, Yuan H, et al. Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice. Microbiome. 2018;6:54 pubmed publisher
Cai C, Ahmad T, Valencia G, Aranda J, Xu J, Beharry K. Intermittent hypoxia suppression of growth hormone and insulin-like growth factor-I in the neonatal rat liver. Growth Horm IGF Res. 2018;41:54-63 pubmed publisher
Reimúndez A, Fernández Peña C, García G, Fernández R, Ordás P, Gallego R, et al. Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice. J Neurosci. 2018;38:3643-3656 pubmed publisher
Lee G, Park C, Cha K, Lee S, Pae M, Han S. Differential effect of dietary vitamin D supplementation on natural killer cell activity in lean and obese mice. J Nutr Biochem. 2018;55:178-184 pubmed publisher
Chartoumpekis D, Yagishita Y, Fazzari M, Palliyaguru D, Rao U, Zaravinos A, et al. Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice. JCI Insight. 2018;3: pubmed publisher
Stadion M, Schwerbel K, Graja A, Baumeier C, Rödiger M, Jonas W, et al. Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans. Diabetologia. 2018;61:1167-1179 pubmed publisher
Scabia G, Barone I, Mainardi M, Ceccarini G, Scali M, Buzzigoli E, et al. The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF. Sci Rep. 2018;8:1781 pubmed publisher
Zheng X, Niu S. Leptin-induced basal Akt phosphorylation and its implication in exercise-mediated improvement of insulin sensitivity. Biochem Biophys Res Commun. 2018;496:37-43 pubmed publisher
Rödiger M, Werno M, Wilhelmi I, Baumeier C, Hesse D, Wettschureck N, et al. Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes. Mol Metab. 2018;8:167-179 pubmed publisher
Xia B, Cai G, Yang H, Wang S, Mitchell G, Wu J. Adipose tissue deficiency of hormone-sensitive lipase causes fatty liver in mice. PLoS Genet. 2017;13:e1007110 pubmed publisher
Maurer L, Tang H, Haumesser J, Altschüler J, Kuhn A, Spranger J, et al. High-fat diet-induced obesity and insulin resistance are characterized by differential beta oscillatory signaling of the limbic cortico-basal ganglia loop. Sci Rep. 2017;7:15555 pubmed publisher
Baumeier C, Schlüter L, Saussenthaler S, Laeger T, Rödiger M, Alaze S, et al. Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease. Mol Metab. 2017;6:1254-1263 pubmed publisher
Reynés B, Klein Hazebroek M, García Ruiz E, Keijer J, Oliver P, Palou A. Specific Features of the Hypothalamic Leptin Signaling Response to Cold Exposure Are Reflected in Peripheral Blood Mononuclear Cells in Rats and Ferrets. Front Physiol. 2017;8:581 pubmed publisher
Haim Y, Bluher M, Konrad D, Goldstein N, Kloting N, Harman Boehm I, et al. ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype. Mol Metab. 2017;6:725-736 pubmed publisher
Theriau C, Connor M. Voluntary physical activity counteracts the proliferative tumor growth microenvironment created by adipose tissue via high-fat diet feeding in female rats. Physiol Rep. 2017;5: pubmed publisher
Steven S, Oelze M, Hanf A, Kröller Schön S, Kashani F, Roohani S, et al. The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats. Redox Biol. 2017;13:370-385 pubmed publisher
Lee M, Shin Y, Jung S, Kim Y. Effects of epigallocatechin-3-gallate on thermogenesis and mitochondrial biogenesis in brown adipose tissues of diet-induced obese mice. Food Nutr Res. 2017;61:1325307 pubmed publisher
Lejonklou M, Dunder L, Bladin E, Pettersson V, Rönn M, Lind L, et al. Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer 344 Rat Offspring. Environ Health Perspect. 2017;125:067018 pubmed publisher
Park C, Park S, Kim M, Kim H, Han S. Effects of mild calorie restriction on lipid metabolism and inflammation in liver and adipose tissue. Biochem Biophys Res Commun. 2017;490:636-642 pubmed publisher
Clemensson E, Clemensson L, Fabry B, Flunkert S, Riess O, Wronski R, et al. Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington disease. PLoS ONE. 2017;12:e0173232 pubmed publisher
Zwamborn R, Slieker R, Mulder P, Zoetemelk I, Verschuren L, Suchiman H, et al. Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice. Sci Rep. 2017;7:43261 pubmed publisher
Fujii N, Narita T, Okita N, Kobayashi M, Furuta Y, Chujo Y, et al. Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction. Aging Cell. 2017;16:508-517 pubmed publisher
Morabito M, Ravussin Y, Mueller B, Skowronski A, Watanabe K, Foo K, et al. Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain. PLoS ONE. 2017;12:e0168226 pubmed publisher
Lee H, Shim E, Lee M, Myung C. Traditional medicine, Sobokchukeo?Tang, modulates the inflammatory response in adipocytes and macrophages. Mol Med Rep. 2017;15:117-124 pubmed publisher
Burnett L, LeDuc C, Sulsona C, Paull D, Rausch R, Eddiry S, et al. Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome. J Clin Invest. 2017;127:293-305 pubmed publisher
Siebert A, Goren I, Pfeilschifter J, Frank S. Anti-Inflammatory Effects of Rosiglitazone in Obesity-Impaired Wound Healing Depend on Adipocyte Differentiation. PLoS ONE. 2016;11:e0168562 pubmed publisher
Song W, Choi J. Korean Curcuma longa L. induces lipolysis and regulates leptin in adipocyte cells and rats. Nutr Res Pract. 2016;10:487-493 pubmed
Chhabra K, Adams J, Jones G, Yamashita M, Schlapschy M, Skerra A, et al. Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity. Mol Metab. 2016;5:869-881 pubmed publisher
Spradley F, Palei A, Granger J. Differential body weight, blood pressure and placental inflammatory responses to normal versus high-fat diet in melanocortin-4 receptor-deficient pregnant rats. J Hypertens. 2016;34:1998-2007 pubmed publisher
Yan L, Sundaram S. Monocyte chemotactic protein-1 deficiency reduces spontaneous metastasis of Lewis lung carcinoma in mice fed a high-fat diet. Oncotarget. 2016;7:24792-9 pubmed publisher
Lee B, Koo J, Yun Jun J, Gavrilova O, Lee Y, Seo A, et al. A mouse model for a partially inactive obesity-associated human MC3R variant. Nat Commun. 2016;7:10522 pubmed publisher
Lytle K, Jump D. Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?. PLoS ONE. 2016;11:e0146942 pubmed publisher
Nimri L, Saadi J, Peri I, Yehuda Shnaidman E, Schwartz B. Mechanisms linking obesity to altered metabolism in mice colon carcinogenesis. Oncotarget. 2015;6:38195-209 pubmed publisher
Haim Y, Bluher M, Slutsky N, Goldstein N, Kloting N, Harman Boehm I, et al. Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1. Autophagy. 2015;11:2074-2088 pubmed publisher
Mendonsa A, Chalfant M, Gorden L, VanSaun M. Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells. PLoS ONE. 2015;10:e0126686 pubmed publisher
Zhou L, Jang K, Moon Y, Wagle S, Kim K, Lee K, et al. Leptin ameliorates ischemic necrosis of the femoral head in rats with obesity induced by a high-fat diet. Sci Rep. 2015;5:9397 pubmed publisher
Kountikov E, Poe J, Maclver N, Rathmell J, Tedder T. A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype. Am J Pathol. 2015;185:617-30 pubmed publisher
de Almeida M, Luquetti S, Sabarense C, do Amaral Corrêa J, Dos Reis L, Santos da Conceição E, et al. Butter naturally enriched in cis-9, trans-11 CLA prevents hyperinsulinemia and increases both serum HDL cholesterol and triacylglycerol levels in rats. Lipids Health Dis. 2014;13:200 pubmed publisher
Zhang Y, Yu L, Cai W, Fan S, Feng L, Ji G, et al. Protopanaxatriol, a novel PPARγ antagonist from Panax ginseng, alleviates steatosis in mice. Sci Rep. 2014;4:7375 pubmed publisher
Heldsinger A, Grabauskas G, Wu X, Zhou S, Lu Y, Song I, et al. Ghrelin induces leptin resistance by activation of suppressor of cytokine signaling 3 expression in male rats: implications in satiety regulation. Endocrinology. 2014;155:3956-69 pubmed publisher
Lim G, Kim H, McCabe M, Chou C, Wang S, Chen L, et al. A leptin-mediated central mechanism in analgesia-enhanced opioid reward in rats. J Neurosci. 2014;34:9779-88 pubmed publisher
Ishii M, Wang G, Racchumi G, Dyke J, Iadecola C. Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons. J Neurosci. 2014;34:9096-106 pubmed publisher
Hall M, Maready M, Hall J, Stec D. Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation. Am J Physiol Endocrinol Metab. 2014;307:E316-25 pubmed publisher
Sajan M, Ivey R, Lee M, Mastorides S, Jurczak M, Samuels V, et al. PKC? haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. Mol Endocrinol. 2014;28:1097-107 pubmed publisher
Fernandez Perez L, Santana Farre R, de Mirecki Garrido M, Garcia I, Guerra B, Mateo Díaz C, et al. Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver. PLoS ONE. 2014;9:e96305 pubmed publisher
Makki K, Taront S, Molendi Coste O, Bouchaert E, Neve B, Eury E, et al. Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice. PLoS ONE. 2014;9:e92684 pubmed publisher
Palou M, Priego T, Romero M, Szostaczuk N, Konieczna J, Cabrer C, et al. Moderate calorie restriction during gestation programs offspring for lower BAT thermogenic capacity driven by thyroid and sympathetic signaling. Int J Obes (Lond). 2015;39:339-45 pubmed publisher
Mercer A, Stuart R, Attard C, Otero Corchon V, Nillni E, Low M. Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice. Am J Physiol Endocrinol Metab. 2014;306:E904-15 pubmed publisher
Ravussin Y, Xiao C, Gavrilova O, Reitman M. Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice. PLoS ONE. 2014;9:e85876 pubmed publisher
Zhang X, Yang R, Jia Y, Cai D, Zhou B, Qu X, et al. Hypermethylation of Sp1 binding site suppresses hypothalamic POMC in neonates and may contribute to metabolic disorders in adults: impact of maternal dietary CLAs. Diabetes. 2014;63:1475-87 pubmed publisher
Rao X, Zhong J, Xu X, Jordan B, Maurya S, Braunstein Z, et al. Exercise protects against diet-induced insulin resistance through downregulation of protein kinase C? in mice. PLoS ONE. 2013;8:e81364 pubmed publisher
Vaill M, Desai B, Harris R. Blockade of the cerebral aqueduct in rats provides evidence of antagonistic leptin responses in the forebrain and hindbrain. Am J Physiol Endocrinol Metab. 2014;306:E414-23 pubmed publisher
Konieczna J, Garcia A, SANCHEZ J, Palou M, Palou A, Pico C. Oral leptin treatment in suckling rats ameliorates detrimental effects in hypothalamic structure and function caused by maternal caloric restriction during gestation. PLoS ONE. 2013;8:e81906 pubmed publisher
Saucillo D, Gerriets V, Sheng J, Rathmell J, Maciver N. Leptin metabolically licenses T cells for activation to link nutrition and immunity. J Immunol. 2014;192:136-44 pubmed publisher
Zhong J, Rao X, Braunstein Z, Taylor A, Narula V, Hazey J, et al. T-cell costimulation protects obesity-induced adipose inflammation and insulin resistance. Diabetes. 2014;63:1289-302 pubmed publisher
Battle M, Gillespie C, Quarshie A, Lanier V, Harmon T, Wilson K, et al. Obesity induced a leptin-Notch signaling axis in breast cancer. Int J Cancer. 2014;134:1605-16 pubmed publisher
Palei A, Spradley F, Granger J. Euglycemic hyperinsulinemia increases blood pressure in pregnant rats independent of placental antiangiogenic and inflammatory factors. Am J Hypertens. 2013;26:1445-51 pubmed publisher
Nakazawa M, Obata Y, Nishino T, Abe S, Nakazawa Y, Abe K, et al. Involvement of leptin in the progression of experimentally induced peritoneal fibrosis in mice. Acta Histochem Cytochem. 2013;46:75-84 pubmed publisher
Gautier E, Westerterp M, Bhagwat N, Cremers S, Shih A, Abdel Wahab O, et al. HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. J Exp Med. 2013;210:339-53 pubmed publisher
Yan J, Mei F, Cheng H, Lao D, Hu Y, Wei J, et al. Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1. Mol Cell Biol. 2013;33:918-26 pubmed publisher
Paschos G, Ibrahim S, Song W, Kunieda T, Grant G, Reyes T, et al. Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med. 2012;18:1768-77 pubmed publisher
Pini M, Castellanos K, Rhodes D, Fantuzzi G. Obesity and IL-6 interact in modulating the response to endotoxemia in mice. Cytokine. 2013;61:71-7 pubmed publisher
Bolton J, Smith S, Huff N, Gilmour M, Foster W, Auten R, et al. Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner. FASEB J. 2012;26:4743-54 pubmed publisher
Kim M, Hur H, Kwon D, Hwang J. Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice. Mol Cell Endocrinol. 2012;358:127-34 pubmed publisher
Chang M, Yeh H, Tsou Y, Wang C, Cheng H, Sung C, et al. HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration. Obesity (Silver Spring). 2012;20:1474-80 pubmed publisher
Ernst M, Haidl I, Zuniga L, Dranse H, Rourke J, Zabel B, et al. Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance. Endocrinology. 2012;153:672-82 pubmed publisher
Sackmann Sala L, Berryman D, Lubbers E, Vesel C, Troike K, List E, et al. Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice. Age (Dordr). 2012;34:1225-37 pubmed
Floryk D, Kurosaka S, Tanimoto R, Yang G, Goltsov A, Park S, et al. Castration-induced changes in mouse epididymal white adipose tissue. Mol Cell Endocrinol. 2011;345:58-67 pubmed publisher
Sackmann Sala L, Berryman D, Munn R, Lubbers E, Kopchick J. Heterogeneity among white adipose tissue depots in male C57BL/6J mice. Obesity (Silver Spring). 2012;20:101-11 pubmed publisher
Lavin D, Joesting J, Chiu G, Moon M, Meng J, Dilger R, et al. Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents. Obesity (Silver Spring). 2011;19:1586-94 pubmed publisher
Lager S, Asterholm I, Schéle E, Jansson N, Nilsson S, Jansson J, et al. Perinatal lack of maternal IL-6 promotes increased adiposity during adulthood in mice. Endocrinology. 2011;152:1336-46 pubmed publisher
Sato H, Isogai Y, Masuda S, Taketomi Y, Miki Y, Kamei D, et al. Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function. J Biol Chem. 2011;286:11632-48 pubmed publisher
Becker M, Siems W, Kluge R, Gembardt F, Schultheiss H, Schirner M, et al. New function for an old enzyme: NEP deficient mice develop late-onset obesity. PLoS ONE. 2010;5: pubmed publisher
Margoni A, Perrea D, Vlachos I, Prokopaki G, Pantopoulou A, Fotis L, et al. Serum leptin, adiponectin and tumor necrosis factor-? in hyperlipidemic rats with/without concomitant diabetes mellitus. Mol Med. 2011;17:36-40 pubmed publisher
Wankhade U, Vella K, Fox D, Good D. Deletion of Nhlh2 results in a defective torpor response and reduced Beta adrenergic receptor expression in adipose tissue. PLoS ONE. 2010;5:e12324 pubmed publisher
Li X, Shridas P, Forrest K, Bailey W, Webb N. Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models. FASEB J. 2010;24:4313-24 pubmed publisher
Valenzuela C, Castillo V, Aguirre C, Ronco A, Llanos M. The CB? receptor antagonist SR141716A reverses adult male mice overweight and metabolic alterations induced by early stress. Obesity (Silver Spring). 2011;19:29-35 pubmed publisher
Shapiro N, Khankin E, van Meurs M, Shih S, Lu S, Yano M, et al. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010;185:517-24 pubmed publisher
Scheller E, Song J, Dishowitz M, Soki F, Hankenson K, Krebsbach P. Leptin functions peripherally to regulate differentiation of mesenchymal progenitor cells. Stem Cells. 2010;28:1071-80 pubmed publisher
Liao F, Liou T, Chiu W, Shieh M, Chien Y. Differential effects of high MUFA with high or low P/S ratio (polyunsaturated to saturated fatty acids) on improving hepatic lipolytic enzymes and mediating PPAR? related with lipoprotein lipase and hormone-sensitive lipase of white adipose tissue in. Int J Obes (Lond). 2010;34:1608-17 pubmed publisher
Koh E, Kim M, Ranjan K, Kim H, Park H, Oh K, et al. eNOS plays a major role in adiponectin synthesis in adipocytes. Am J Physiol Endocrinol Metab. 2010;298:E846-53 pubmed publisher
Collison K, Maqbool Z, Inglis A, Makhoul N, Saleh S, Bakheet R, et al. Effect of dietary monosodium glutamate on HFCS-induced hepatic steatosis: expression profiles in the liver and visceral fat. Obesity (Silver Spring). 2010;18:1122-34 pubmed publisher
Kiefer F, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, et al. Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance. Diabetes. 2010;59:935-46 pubmed publisher
Palou M, Priego T, SANCHEZ J, Torrens J, Palou A, Pico C. Moderate caloric restriction in lactating rats protects offspring against obesity and insulin resistance in later life. Endocrinology. 2010;151:1030-41 pubmed publisher
Alm A, Li K, Yang D, Andersson R, Lu Y, Wang X. Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice. Cytokine. 2010;49:256-63 pubmed publisher
Collison K, Makhoul N, Inglis A, Al Johi M, Zaidi M, Maqbool Z, et al. Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory. Physiol Behav. 2010;99:334-42 pubmed publisher
Schroeder M, Zagoory Sharon O, Shbiro L, Marco A, Hyun J, Moran T, et al. Development of obesity in the Otsuka Long-Evans Tokushima Fatty rat. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1749-60 pubmed publisher
Pini M, Fantuzzi G. Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice. J Leukoc Biol. 2010;87:51-8 pubmed publisher
Barros C, Almeida S, Mori M, Valero V, Haro A, Batista E, et al. Efficient method for obtaining Lep(ob)/Lep(ob)-derived animal models using adipose tissue transplantations. Int J Obes (Lond). 2009;33:938-44 pubmed publisher
Columba Cabezas S, Iaffaldano G, Chiarotti F, Alleva E, Cirulli F. Early handling increases susceptibility to experimental autoimmune encephalomyelitis (EAE) in C57BL/6 male mice. J Neuroimmunol. 2009;212:10-6 pubmed publisher
Sherry C, Kim S, Freund G. Accelerated recovery from acute hypoxia in obese mice is due to obesity-associated up-regulation of interleukin-1 receptor antagonist. Endocrinology. 2009;150:2660-7 pubmed publisher
Lim G, Wang S, Zhang Y, Tian Y, Mao J. Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents. J Clin Invest. 2009;119:295-304 pubmed publisher
Feng D, Wang Y, Mei Y, Xu Y, Xu H, Lu Y, et al. Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury. Lab Invest. 2009;89:222-30 pubmed publisher
Collison K, Maqbool Z, Saleh S, Inglis A, Makhoul N, Bakheet R, et al. Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease. J Lipid Res. 2009;50:1521-37 pubmed publisher
Van Nas A, GuhaThakurta D, Wang S, Yehya N, Horvath S, Zhang B, et al. Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology. 2009;150:1235-49 pubmed publisher
Osei Hyiaman D, Liu J, Zhou L, Godlewski G, Harvey White J, Jeong W, et al. Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J Clin Invest. 2008;118:3160-9 pubmed publisher
Trotter Mayo R, Roberts M. Leptin acts in the periphery to protect thymocytes from glucocorticoid-mediated apoptosis in the absence of weight loss. Endocrinology. 2008;149:5209-18 pubmed publisher
Zagoory Sharon O, Schroeder M, Levine A, Moran T, Weller A. Adaptation to lactation in OLETF rats lacking CCK-1 receptors: body weight, fat tissues, leptin and oxytocin. Int J Obes (Lond). 2008;32:1211-21 pubmed publisher
Pini M, Gove M, Sennello J, van Baal J, Chan L, Fantuzzi G. Role and regulation of adipokines during zymosan-induced peritoneal inflammation in mice. Endocrinology. 2008;149:4080-5 pubmed publisher
Sipos W, Rauner M, Skalicky M, Viidik A, Hofbauer G, Schett G, et al. Running has a negative effect on bone metabolism and proinflammatory status in male aged rats. Exp Gerontol. 2008;43:578-83 pubmed publisher
Sabatakos G, Rowe G, Kveiborg M, Wu M, Neff L, Chiusaroli R, et al. Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity. J Bone Miner Res. 2008;23:584-95 pubmed publisher
Mehrabian M, Schulthess F, Nebohacova M, Castellani L, Zhou Z, Hartiala J, et al. Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia. 2008;51:978-88 pubmed publisher
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product information
brand :
R&D Systems
SKU :
MOB00
product name :
Leptin/OB ELISA
unit sizes :
1 Kit (2 Plates) (also 1 Pack (50 Plates), 1 Pack (6 Plates))
description :
The Mouse/Rat Leptin Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies mouse, rat Leptin/OB in cell culture supernates (50 ul), serum (20 ul), edta plasma (20 ul).
target :
Leptin/OB
category :
ELISAs
species :
Mouse, Rat
specificity :
Natural and recombinant mouse and rat Leptin. This assay cross-reacts 0.24% with Human Leptin.
gene symbol :
Lep
kit type :
Solid Phase Sandwich ELISA
assay length :
4.5 hours
elisaSampleTypes :
Cell Culture Supernates (50 uL), Serum (20 uL), EDTA Plasma (20 uL)
elisaSensitivity :
22 pg/mL
elisaRange :
62.50 - 4000 pg/mL
catalog number base :
MOB00
applications :
ELISA
extended description :
Product is in the process of discontinuation and has been replaced by catalog # MOB00B
USD :
659 USD
applications abr :
ELISA
product details :
The Quantikine Mouse Leptin Immunoassay is a 4.5 hour solid phase ELISA designed to measure soluble mouse leptin in cell culture supernates, serum*, and plasma. It contains recombinant mouse leptin expressed in E. coli and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse leptin accurately. Results obtained measuring natural mouse leptin showed dose-response curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse leptin. *Pregnant mouse serum from the second trimester of pregnancy through post-partum day 1 require acid/urea activation of mouse leptin.
alt names :
FLJ94114, LEP, leptin, leptin (murine obesity homolog), leptin (obesity homolog, mouse), OB, Obese protein, obese, mouse, homolog of, Obesity factor, OBOBS
storage :
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.