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product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Mouse/Rat GDF-15 Quantikine ELISA Kit
catalog :
MGD150
quantity :
1 Kit
price :
655 USD
citations: 42
Reference
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Yulyaningsih E, Suh J, Fanok M, Chau R, Solanoy H, Takahashi R, et al. DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response. elife. 2024;12: pubmed publisher
Labour A, Lac M, Frassin L, Lair B, Murphy E, Maslo C, et al. GDF15 is dispensable for the insulin-sensitizing effects of chronic exercise. Cell Rep. 2024;43:114577 pubmed publisher
Mulcahy M, El Habbal N, Redd J, Sun H, Gregg B, Bridges D. GDF15 knockout does not substantially impact perinatal body weight or neonatal outcomes in mice. bioRxiv. 2024;: pubmed publisher
Lund C, Ranea Robles P, Falk S, Rausch D, Skovbjerg G, Vibe Petersen V, et al. Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R. Nat Commun. 2024;15:1192 pubmed publisher
Guo X, Asthana P, Zhai L, Cheng K, Gurung S, Huang J, et al. Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis. Nat Commun. 2024;15:1034 pubmed publisher
Jena J, Garc xed a Pe xf1 a L, Weatherford E, Marti A, Bjorkman S, Kato K, et al. GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes. elife. 2023;12: pubmed publisher
Kojima Y, Mishiro Sato E, Fujishita T, Satoh K, Kajino Sakamoto R, Oze I, et al. Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia. Nat Commun. 2023;14:6246 pubmed publisher
Tezze C, Amendolagine F, Nogara L, Baraldo M, Ciciliot S, Arcidiacono D, et al. A combination of metformin and galantamine exhibits synergistic benefits in the treatment of sarcopenia. JCI Insight. 2023;8: pubmed publisher
Kanta J, Deisen L, Johann K, Holm S, Lundsgaard A, Lund J, et al. Dietary medium-chain fatty acids reduce food intake via the GDF15-GFRAL axis in mice. Mol Metab. 2023;74:101760 pubmed publisher
Klein Hazebroek M, Laterveer R, Kutschke M, Ram x161 ak Mar x10d eta V, Barthem C, Keipert S. Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21. Sci Rep. 2023;13:10288 pubmed publisher
Singh A, Rourk K, Bernier A, de Lartigue G. Non-Nutritive Sweetened Beverages Impair Therapeutic Benefits of Metformin in Prediabetic Diet-Induced Obese Mice. Nutrients. 2023;15: pubmed publisher
Southwell N, Primiano G, Nadkarni V, Attarwala N, Beattie E, Miller D, et al. A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy. EMBO Mol Med. 2023;15:e16951 pubmed publisher
Kim Muller J, Song L, LaCarubba Paulhus B, Pashos E, Li X, Rinaldi A, et al. GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia. Cell Rep. 2023;42:111947 pubmed publisher
Zapata R, Carretero M, Reis F, Chaudry B, Ofrecio J, Zhang D, et al. Adipocytes control food intake and weight regain via Vacuolar-type H+ ATPase. Nat Commun. 2022;13:5092 pubmed publisher
Ni Y, Wu G, Cai J, Zhang R, Zheng Y, Liu J, et al. Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation. Int J Biol Sci. 2022;18:5168-5184 pubmed publisher
Queiroz A, Dantas E, Ramsamooj S, Murthy A, Ahmed M, Zunica E, et al. Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer. Nat Commun. 2022;13:4633 pubmed publisher
Maschalidi S, Mehrotra P, Ke xe7 eli B, De Cleene H, Lecomte K, Van der Cruyssen R, et al. Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes. Nature. 2022;606:776-784 pubmed publisher
McElroy G, Chakrabarty R, D Alessandro K, Hu Y, Vasan K, Tan J, et al. Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice. Sci Rep. 2022;12:5196 pubmed publisher
Morató L, Astori S, Zalachoras I, Rodrigues J, Ghosal S, Huang W, et al. eNAMPT actions through nucleus accumbens NAD+/SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress. Sci Adv. 2022;8:eabj9109 pubmed publisher
Geppert J, Walth A, Terr xf3 n Exp xf3 sito R, Kaltenecker D, Morigny P, Machado J, et al. Aging Aggravates Cachexia in Tumor-Bearing Mice. Cancers (Basel). 2021;14: pubmed publisher
Moritoh Y, Abe S, Akiyama H, Kobayashi A, Koyama R, Hara R, et al. The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals. Nat Commun. 2021;12:4847 pubmed publisher
Yang M, Darwish T, Larraufie P, Rimmington D, Cimino I, Goldspink D, et al. Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells. Sci Rep. 2021;11:2529 pubmed publisher
Selen E, Choi J, Wolfgang M. Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease. JCI Insight. 2021;6: pubmed publisher
Pereyra A, Rajan A, Ferreira C, Ellis J. Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation. Cell Rep. 2020;33:108374 pubmed publisher
Kim H, Kim K, Kang M, Lim S. Growth differentiation factor-15 as a biomarker for sarcopenia in aging humans and mice. Exp Gerontol. 2020;142:111115 pubmed publisher
Chian C, Lee Y, Lee Y, Chen Y, Wang C, Lee W, et al. Cilostazol ameliorates diabetic nephropathy by inhibiting highglucose- induced apoptosis. Korean J Physiol Pharmacol. 2020;24:403-412 pubmed publisher
Stolina M, Luo X, Dwyer D, Han C, Chen R, Zhang Y, et al. The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15. PLoS ONE. 2020;15:e0231234 pubmed publisher
Nguyen I, Brandt M, van de Wouw J, van Drie R, Wesseling M, Cramer M, et al. Both male and female obese ZSF1 rats develop cardiac dysfunction in obesity-induced heart failure with preserved ejection fraction. PLoS ONE. 2020;15:e0232399 pubmed publisher
Walker R, Barrandon O, Poggioli T, Dagdeviren S, Carroll S, Mills M, et al. Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice. Sci Rep. 2020;10:4561 pubmed publisher
Gil C, Ost M, Kasch J, Schumann S, Heider S, Klaus S. Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice. Sci Rep. 2019;9:20120 pubmed publisher
Flicker D, Sancak Y, Mick E, Goldberger O, Mootha V. Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics. Cell Rep. 2019;27:1364-1375.e5 pubmed publisher
Tran T, Yang J, Gardner J, Xiong Y. GDF15 deficiency promotes high fat diet-induced obesity in mice. PLoS ONE. 2018;13:e0201584 pubmed publisher
Ito T, Nakanishi Y, Yamaji N, Murakami S, Schaffer S. Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse. Biol Pharm Bull. 2018;41:435-439 pubmed publisher
Zhang M, Sun W, Qian J, Tang Y. Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid ?-oxidation and ketogenesis via activating XBP1 signaling in liver. Redox Biol. 2018;16:87-96 pubmed publisher
Jones J, Cadena S, Gong C, Wang X, Chen Z, Wang S, et al. Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15. Cell Rep. 2018;22:1522-1530 pubmed publisher
Coleman V, Sa Nguanmoo P, Koenig J, Schulz T, Grune T, Klaus S, et al. Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling. Sci Rep. 2018;8:2446 pubmed publisher
Lee J, Choi J, Selen Alpergin E, Zhao L, Hartung T, Scafidi S, et al. Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance. Cell Rep. 2017;20:655-667 pubmed publisher
Matsuhashi T, Sato T, Kanno S, Suzuki T, Matsuo A, Oba Y, et al. Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases. EBioMedicine. 2017;20:27-38 pubmed publisher
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Ban N, Siegfried C, Lin J, Shui Y, Sein J, Pita Thomas W, et al. GDF15 is elevated in mice following retinal ganglion cell death and in glaucoma patients. JCI Insight. 2017;2: pubmed publisher
Fujimura K, Wakino S, Minakuchi H, Hasegawa K, Hosoya K, Komatsu M, et al. Ghrelin protects against renal damages induced by angiotensin-II via an antioxidative stress mechanism in mice. PLoS ONE. 2014;9:e94373 pubmed publisher
product information
master code :
MGD150
SKU :
MGD150
product name :
Mouse/Rat GDF-15 Quantikine ELISA Kit
unit size :
1 Kit
description :
The Mouse/Rat GDF-15 Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies mouse, rat GDF-15 in cell culture supernates (50 ul), serum (50 ul), edta plasma (50 ul), heparin plasma (50 ul), urine (10 ul).
target :
GDF-15
category :
ELISAs
species :
Mouse, Rat
specificity :
Natural mouse and rat GDF-15, recombinant mouse mature GDF-15, precursor GDF-15, and GDF-15/BMP-2 heterodimer. It does not detect monomeric recombinant mouse GDF-15.
gene symbol :
Gdf15
kit type :
Solid Phase Sandwich ELISA
assay length :
4.5 hours
elisaSampleTypes :
Cell Culture Supernates (50 uL), Serum (50 uL), EDTA Plasma (50 uL), Heparin Plasma (50 uL), Urine (10 uL)
elisaSensitivity :
2.2 pg/mL
elisaRange :
7.80 - 500 pg/mL
top caption :
Mouse/Rat GDF-15 ELISA Standard Curve
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Mouse/Rat GDF-15 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse and rat GDF-15 in cell culture supernates, serum, plasma, and urine. It contains E. coli -expressed recombinant mouse GDF-15 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural mouse or rat GDF-15 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring mouse and rat GDF-15.
alt names :
GDF15, growth differentiation factor 15, growth/differentiation factor 15, Macrophage inhibitory cytokine 1, MIC-1, MIC-1NSAID-activated gene 1 protein, MIC1Prostate differentiation factor, NAG-1, NAG-1NSAID-regulated gene 1 protein, NSAID (nonsteroidal inflammatory drug)-activated protein 1, PDF, PDFGDF-15, PLAB, PLABNRG-1, Placental bone morphogenetic protein, Placental TGF-beta, PTGF-beta, PTGFBPTGF-beta
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.