| Reference |
|---|
Fu W, Lai Y, Li K, Yang Y, Guo X, Gong Q, et al. Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism. Cell Res. 2025;35:117-131 pubmed publisher
|
Yulyaningsih E, Suh J, Fanok M, Chau R, Solanoy H, Takahashi R, et al. DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response. elife. 2024;12: pubmed publisher
|
Labour A, Lac M, Frassin L, Lair B, Murphy E, Maslo C, et al. GDF15 is dispensable for the insulin-sensitizing effects of chronic exercise. Cell Rep. 2024;43:114577 pubmed publisher
|
Mulcahy M, El Habbal N, Redd J, Sun H, Gregg B, Bridges D. GDF15 knockout does not substantially impact perinatal body weight or neonatal outcomes in mice. bioRxiv. 2024;: pubmed publisher
|
Lund C, Ranea Robles P, Falk S, Rausch D, Skovbjerg G, Vibe Petersen V, et al. Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R. Nat Commun. 2024;15:1192 pubmed publisher
|
Guo X, Asthana P, Zhai L, Cheng K, Gurung S, Huang J, et al. Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis. Nat Commun. 2024;15:1034 pubmed publisher
|
Jena J, Garc xed a Pe xf1 a L, Weatherford E, Marti A, Bjorkman S, Kato K, et al. GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes. elife. 2023;12: pubmed publisher
|
Kojima Y, Mishiro Sato E, Fujishita T, Satoh K, Kajino Sakamoto R, Oze I, et al. Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia. Nat Commun. 2023;14:6246 pubmed publisher
|
Tezze C, Amendolagine F, Nogara L, Baraldo M, Ciciliot S, Arcidiacono D, et al. A combination of metformin and galantamine exhibits synergistic benefits in the treatment of sarcopenia. JCI Insight. 2023;8: pubmed publisher
|
Kanta J, Deisen L, Johann K, Holm S, Lundsgaard A, Lund J, et al. Dietary medium-chain fatty acids reduce food intake via the GDF15-GFRAL axis in mice. Mol Metab. 2023;74:101760 pubmed publisher
|
Klein Hazebroek M, Laterveer R, Kutschke M, Ram x161 ak Mar x10d eta V, Barthem C, Keipert S. Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21. Sci Rep. 2023;13:10288 pubmed publisher
|
Singh A, Rourk K, Bernier A, de Lartigue G. Non-Nutritive Sweetened Beverages Impair Therapeutic Benefits of Metformin in Prediabetic Diet-Induced Obese Mice. Nutrients. 2023;15: pubmed publisher
|
Southwell N, Primiano G, Nadkarni V, Attarwala N, Beattie E, Miller D, et al. A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy. EMBO Mol Med. 2023;15:e16951 pubmed publisher
|
Kim Muller J, Song L, LaCarubba Paulhus B, Pashos E, Li X, Rinaldi A, et al. GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia. Cell Rep. 2023;42:111947 pubmed publisher
|
Zapata R, Carretero M, Reis F, Chaudry B, Ofrecio J, Zhang D, et al. Adipocytes control food intake and weight regain via Vacuolar-type H+ ATPase. Nat Commun. 2022;13:5092 pubmed publisher
|
Ni Y, Wu G, Cai J, Zhang R, Zheng Y, Liu J, et al. Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation. Int J Biol Sci. 2022;18:5168-5184 pubmed publisher
|
Queiroz A, Dantas E, Ramsamooj S, Murthy A, Ahmed M, Zunica E, et al. Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer. Nat Commun. 2022;13:4633 pubmed publisher
|
Maschalidi S, Mehrotra P, Ke xe7 eli B, De Cleene H, Lecomte K, Van der Cruyssen R, et al. Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes. Nature. 2022;606:776-784 pubmed publisher
|
McElroy G, Chakrabarty R, D Alessandro K, Hu Y, Vasan K, Tan J, et al. Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice. Sci Rep. 2022;12:5196 pubmed publisher
|
Morató L, Astori S, Zalachoras I, Rodrigues J, Ghosal S, Huang W, et al. eNAMPT actions through nucleus accumbens NAD+/SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress. Sci Adv. 2022;8:eabj9109 pubmed publisher
|
Geppert J, Walth A, Terr xf3 n Exp xf3 sito R, Kaltenecker D, Morigny P, Machado J, et al. Aging Aggravates Cachexia in Tumor-Bearing Mice. Cancers (Basel). 2021;14: pubmed publisher
|
Moritoh Y, Abe S, Akiyama H, Kobayashi A, Koyama R, Hara R, et al. The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals. Nat Commun. 2021;12:4847 pubmed publisher
|
Yang M, Darwish T, Larraufie P, Rimmington D, Cimino I, Goldspink D, et al. Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells. Sci Rep. 2021;11:2529 pubmed publisher
|
Selen E, Choi J, Wolfgang M. Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease. JCI Insight. 2021;6: pubmed publisher
|
Pereyra A, Rajan A, Ferreira C, Ellis J. Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation. Cell Rep. 2020;33:108374 pubmed publisher
|
Kim H, Kim K, Kang M, Lim S. Growth differentiation factor-15 as a biomarker for sarcopenia in aging humans and mice. Exp Gerontol. 2020;142:111115 pubmed publisher
|
Chian C, Lee Y, Lee Y, Chen Y, Wang C, Lee W, et al. Cilostazol ameliorates diabetic nephropathy by inhibiting highglucose- induced apoptosis. Korean J Physiol Pharmacol. 2020;24:403-412 pubmed publisher
|
Stolina M, Luo X, Dwyer D, Han C, Chen R, Zhang Y, et al. The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15. PLoS ONE. 2020;15:e0231234 pubmed publisher
|
Nguyen I, Brandt M, van de Wouw J, van Drie R, Wesseling M, Cramer M, et al. Both male and female obese ZSF1 rats develop cardiac dysfunction in obesity-induced heart failure with preserved ejection fraction. PLoS ONE. 2020;15:e0232399 pubmed publisher
|
Walker R, Barrandon O, Poggioli T, Dagdeviren S, Carroll S, Mills M, et al. Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice. Sci Rep. 2020;10:4561 pubmed publisher
|
Gil C, Ost M, Kasch J, Schumann S, Heider S, Klaus S. Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice. Sci Rep. 2019;9:20120 pubmed publisher
|
Flicker D, Sancak Y, Mick E, Goldberger O, Mootha V. Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics. Cell Rep. 2019;27:1364-1375.e5 pubmed publisher
|
Tran T, Yang J, Gardner J, Xiong Y. GDF15 deficiency promotes high fat diet-induced obesity in mice. PLoS ONE. 2018;13:e0201584 pubmed publisher
|
Ito T, Nakanishi Y, Yamaji N, Murakami S, Schaffer S. Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse. Biol Pharm Bull. 2018;41:435-439 pubmed publisher
|
Zhang M, Sun W, Qian J, Tang Y. Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid ?-oxidation and ketogenesis via activating XBP1 signaling in liver. Redox Biol. 2018;16:87-96 pubmed publisher
|
Jones J, Cadena S, Gong C, Wang X, Chen Z, Wang S, et al. Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15. Cell Rep. 2018;22:1522-1530 pubmed publisher
|
Coleman V, Sa Nguanmoo P, Koenig J, Schulz T, Grune T, Klaus S, et al. Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling. Sci Rep. 2018;8:2446 pubmed publisher
|
Lee J, Choi J, Selen Alpergin E, Zhao L, Hartung T, Scafidi S, et al. Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance. Cell Rep. 2017;20:655-667 pubmed publisher
|
Matsuhashi T, Sato T, Kanno S, Suzuki T, Matsuo A, Oba Y, et al. Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases. EBioMedicine. 2017;20:27-38 pubmed publisher
|
Villars F, Pietra C, Giuliano C, Lutz T, Riediger T. Oral Treatment with the Ghrelin Receptor Agonist HM01 Attenuates Cachexia in Mice Bearing Colon-26 (C26) Tumors. Int J Mol Sci. 2017;18: pubmed publisher
|
Ban N, Siegfried C, Lin J, Shui Y, Sein J, Pita Thomas W, et al. GDF15 is elevated in mice following retinal ganglion cell death and in glaucoma patients. JCI Insight. 2017;2: pubmed publisher
|
Fujimura K, Wakino S, Minakuchi H, Hasegawa K, Hosoya K, Komatsu M, et al. Ghrelin protects against renal damages induced by angiotensin-II via an antioxidative stress mechanism in mice. PLoS ONE. 2014;9:e94373 pubmed publisher
|