product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human EMMPRIN/CD147 Antibody
catalog :
MAB972-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
439 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
109403
reactivity :
human
application :
western blot, ELISA, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, proximity ligation assay
more info or order :
R&D Systems product webpage
citations: 10
Reference
Lau H, Passalacqua I, Jung J, Kwon Y, Zocco D, Park S, et al. Unraveling the surface marker signature of cell-derived vesicles via proteome analysis and nanoparticle flow cytometry. Sci Rep. 2024;14:121 pubmed publisher
Wang P, Hao X, Li X, Yan Y, Tian W, Xiao L, et al. Curcumin inhibits adverse psychological stress-induced proliferation and invasion of glioma cells via down-regulating the ERK/MAPK pathway. J Cell Mol Med. 2021;25:7190-7203 pubmed publisher
Aoki M, Koga K, Miyazaki M, Hamasaki M, Koshikawa N, Oyama M, et al. CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts. BMC Cancer. 2019;19:912 pubmed publisher
Andersen A, Samsøe Petersen J, Oernbo E, Boedtkjer E, Moreira J, Kveiborg M, et al. The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms. Int J Cancer. 2018;142:2529-2542 pubmed publisher
Marchiq I, Albrengues J, Granja S, Gaggioli C, Pouysségur J, Simon M. Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction. Oncotarget. 2015;6:24636-48 pubmed publisher
Granja S, Marchiq I, Le Floch R, Moura C, Baltazar F, Pouysségur J. Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status. Oncotarget. 2015;6:6708-21 pubmed
Agrawal S, Silva C, Wang J, Tong J, Yong V. A novel anti-EMMPRIN function-blocking antibody reduces T cell proliferation and neurotoxicity: relevance to multiple sclerosis. J Neuroinflammation. 2012;9:64 pubmed publisher
Määttä M, Tervahartiala T, Kaarniranta K, Tang Y, Yan L, Tuukkanen J, et al. Immunolocalization of EMMPRIN (CD147) in the human eye and detection of soluble form of EMMPRIN in ocular fluids. Curr Eye Res. 2006;31:917-24 pubmed
Egawa N, Koshikawa N, Tomari T, Nabeshima K, Isobe T, Seiki M. Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells. J Biol Chem. 2006;281:37576-85 pubmed
Haug C, Lenz C, Diaz F, Bachem M. Oxidized low-density lipoproteins stimulate extracellular matrix metalloproteinase Inducer (EMMPRIN) release by coronary smooth muscle cells. Arterioscler Thromb Vasc Biol. 2004;24:1823-9 pubmed
product information
master code :
MAB972
SKU :
MAB972-100
product name :
Human EMMPRIN/CD147 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human EMMPRIN/CD147 Antibody from R&D Systems is a mouse monoclonal antibody to EMMPRIN/CD147. This antibody reacts with human. The Human EMMPRIN/CD147 Antibody has been validated for the following applications: Westen Blot,ELISA Development,Proximity Ligation Assay (PLA),Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA,Knockout Validated.
target :
EMMPRIN/CD147
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
109403
conjugate :
Unconjugated
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human EMMPRIN/CD147, Ala22-His205, Accession # Q54A51
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human EMMPRIN/CD147 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse EMMPRIN is observed.
gene symbol :
BSG
Antibody validation :
Knockout/Knockdown
top caption :
Detection of Human EMMPRIN/CD147 antibody by Western Blot.
accessionNumbers :
Q54A51
applications :
Westen Blot,ELISA Development,Proximity Ligation Assay (PLA),Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA,Knockout Validated
USD :
439 USD
alt names :
5F7, basigin, basigin (Ok blood group), BSG, CD147, CD147 antigen, Collagenase stimulatory factor, EMMPRINTCSF, Extracellular matrix metalloproteinase inducer, Leukocyte activation antigen M6, M6, OK, OK blood group antigen, Tumor cell-derived collagenase stimulatory factor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.