Human TIMP-2 Antibody | R&D Systems MAB971 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TIMP-2 Antibody

catalog :

MAB971

quantity :

500 ug (also 25 ug)

price :

569 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

89025

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 14

Reference
Lin L, Nayak B, Osmulski P, Wang E, Wang C, Valente P, et al. PAI-1 uncouples integrin-β1 from restrain by membrane-bound β-catenin to promote collagen fibril remodeling in obesity-related neoplasms. Cell Rep. 2024;43:114527 pubmed publisher
Backe S, Votra S, Stokes M, Sebesty xe9 n E, Castelli M, Torielli L, et al. PhosY-secretome profiling combined with kinase-substrate interaction screening defines active c-Src-driven extracellular signaling. Cell Rep. 2023;42:112539 pubmed publisher
Gerwinn T, Salemi S, Schori L, Planta D, Eberli D, Horst M. Improved contractile potential in detrusor microtissues from pediatric patients with end stage lower urinary tract dysfunction. Front Cell Dev Biol. 2022;10:1007265 pubmed publisher
Wang Y, Yang Q, Cheng Y, Gao M, Kuang L, Wang C. Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/β-Catenin Pathway. Med Sci Monit. 2018;24:9110-9119 pubmed publisher
Yang Y, Li Q, Guo L. MicroRNA‑122 acts as tumor suppressor by targeting TRIM29 and blocking the activity of PI3K/AKT signaling in nasopharyngeal carcinoma in vitro. Mol Med Rep. 2018;17:8244-8252 pubmed publisher
Armento A, Ilina E, Kaoma T, Muller A, Vallar L, Niclou S, et al. Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors. Int J Oncol. 2017;51:702-714 pubmed publisher
Peters C, Michelson A, Flaumenhaft R. Granule exocytosis is required for platelet spreading: differential sorting of ?-granules expressing VAMP-7. Blood. 2012;120:199-206 pubmed publisher
Ha x142 o x144 A, Nowak Markwitz E, Donizy P, Matkowski R, Maciejczyk A, Gansukh T, et al. Enhanced immunoreactivity of TIMP-2 in the stromal compartment of tumor as a marker of favorable prognosis in ovarian cancer patients. J Histochem Cytochem. 2012;60:491-501 pubmed publisher
Yang S, Cody J, Rivera A, Waehler R, Wang M, Kimball K, et al. Conditionally replicating adenovirus expressing TIMP2 for ovarian cancer therapy. Clin Cancer Res. 2011;17:538-49 pubmed publisher
Li M, Hou X, Shao J, Tang C, Li D. The DSCs-expressed CD82 controls the invasiveness of trophoblast cells via integrinbeta1/MAPK/MAPK3/1 signaling pathway in human first-trimester pregnancy. Biol Reprod. 2010;82:968-79 pubmed publisher
Villeneuve J, Block A, Le Bousse Kerdiles M, Lepreux S, Nurden P, Ripoche J, et al. Tissue inhibitors of matrix metalloproteinases in platelets and megakaryocytes: a novel organization for these secreted proteins. Exp Hematol. 2009;37:849-56 pubmed publisher
Kong M, Gaggar A, Li Y, Winkler M, Blalock J, Clancy J. Matrix metalloproteinase activity in pediatric acute lung injury. Int J Med Sci. 2009;6:9-17 pubmed
Caruso R, Fina D, Peluso I, Fantini M, Tosti C, Del Vecchio Blanco G, et al. IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J Immunol. 2007;178:5957-65 pubmed
Monteleone G, Caruso R, Fina D, Peluso I, Gioia V, Stolfi C, et al. Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut. 2006;55:1774-80 pubmed

product information

master code :

MAB971

SKU :

MAB971

product name :

Human TIMP-2 Antibody

unit size :

500 ug (also 25 ug)

description :

The Human TIMP-2 Antibody from R&D Systems is a mouse monoclonal antibody to TIMP-2. This antibody reacts with human. The Human TIMP-2 Antibody has been validated for the following applications: Western Blot,Immunocytochemistry,Functional Assay,Cell-based ELISA,Immunoprecipitation,Immunohistochemistry.

target :

TIMP-2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

89025

conjugate :

Unconjugated

host :

Mouse

immunogen :

Chinese hamster ovary cell line CHO-derived recombinant human TIMP-2, Cys27-Pro220, Accession # P16035

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human TIMP-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human TIMP-1 or recombinant mouse TIMP-1 is observed.

gene symbol :

TIMP2

top caption :

Detection of Human TIMP-2 antibody by Western Blot.

accessionNumbers :

P16035

applications :

Western Blot,Immunocytochemistry,Functional Assay,Cell-based ELISA,Immunoprecipitation,Immunohistochemistry

USD :

569 USD

alt names :

CSC-21Ktissue inhibitor of metalloproteinase 2, metalloproteinase inhibitor 2, TIMP metallopeptidase inhibitor 2, TIMP2, TIMP-2, Tissue inhibitor of metalloproteinases 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage