Human TIMP-1 Antibody | R&D Systems MAB970-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TIMP-1 Antibody

catalog :

MAB970-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

63515

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, dot blot

more info or order :

R&D Systems product webpage

citations: 19

Reference
Wu S, Hou T, Kau H, Tsai C. Effect of Pirfenidone on TGF-β1-Induced Myofibroblast Differentiation and Extracellular Matrix Homeostasis of Human Orbital Fibroblasts in Graves' Ophthalmopathy. Biomolecules. 2021;11: pubmed publisher
Hou T, Wu S, Kau H, Tsai C. JNK and p38 Inhibitors Prevent Transforming Growth Factor-β1-Induced Myofibroblast Transdifferentiation in Human Graves' Orbital Fibroblasts. Int J Mol Sci. 2021;22: pubmed publisher
Xiao W, Wang L, Howard J, Kolhe R, Rojiani A, Rojiani M. TIMP-1-Mediated Chemoresistance via Induction of IL-6 in NSCLC. Cancers (Basel). 2019;11: pubmed publisher
Carp xe9 n T, Sorsa T, Jouhi L, Tervahartiala T, Haglund C, Syrj xe4 nen S, et al. High levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) in the serum are associated with poor prognosis in HPV-negative squamous cell oropharyngeal cancer. Cancer Immunol Immunother. 2019;68:1263-1272 pubmed publisher
Wang X, Rojas Quintero J, Wilder J, Tesfaigzi Y, Zhang D, Owen C. Tissue Inhibitor of Metalloproteinase-1 Promotes Polymorphonuclear Neutrophil (PMN) Pericellular Proteolysis by Anchoring Matrix Metalloproteinase-8 and -9 to PMN Surfaces. J Immunol. 2019;202:3267-3281 pubmed publisher
Li Q, Chen L, Ao M, Chiu J, Zhang Z, Zhang H, et al. Serum fucosylated prostate-specific antigen (PSA) improves the differentiation of aggressive from non-aggressive prostate cancers. Theranostics. 2015;5:267-76 pubmed publisher
Estrada Gutierrez G, Cappello R, Mishra N, Romero R, Strauss J, Walsh S. Increased expression of matrix metalloproteinase-1 in systemic vessels of preeclamptic women: a critical mediator of vascular dysfunction. Am J Pathol. 2011;178:451-60 pubmed publisher
Schipper H, de Jager W, van Dijk M, Meerding J, Zelissen P, Adan R, et al. A multiplex immunoassay for human adipokine profiling. Clin Chem. 2010;56:1320-8 pubmed publisher
Li M, Hou X, Shao J, Tang C, Li D. The DSCs-expressed CD82 controls the invasiveness of trophoblast cells via integrinbeta1/MAPK/MAPK3/1 signaling pathway in human first-trimester pregnancy. Biol Reprod. 2010;82:968-79 pubmed publisher
Lucio Eterovic A, Piao Y, de Groot J. Mediators of glioblastoma resistance and invasion during antivascular endothelial growth factor therapy. Clin Cancer Res. 2009;15:4589-99 pubmed publisher
Cavallo C, Desando G, Facchini A, Grigolo B. Chondrocytes from patients with osteoarthritis express typical extracellular matrix molecules once grown onto a three-dimensional hyaluronan-based scaffold. J Biomed Mater Res A. 2010;93:86-95 pubmed publisher
Villeneuve J, Block A, Le Bousse Kerdiles M, Lepreux S, Nurden P, Ripoche J, et al. Tissue inhibitors of matrix metalloproteinases in platelets and megakaryocytes: a novel organization for these secreted proteins. Exp Hematol. 2009;37:849-56 pubmed publisher
Kong M, Gaggar A, Li Y, Winkler M, Blalock J, Clancy J. Matrix metalloproteinase activity in pediatric acute lung injury. Int J Med Sci. 2009;6:9-17 pubmed
Nicol G, Han M, Kim J, Birse C, Brand E, Nguyen A, et al. Use of an immunoaffinity-mass spectrometry-based approach for the quantification of protein biomarkers from serum samples of lung cancer patients. Mol Cell Proteomics. 2008;7:1974-82 pubmed publisher
Naveau A, Reinald N, Fournier B, Durand E, Lafont A, Coulomb B, et al. Gingival fibroblasts inhibit MMP-1 and MMP-3 activities in an ex-vivo artery model. Connect Tissue Res. 2007;48:300-8 pubmed
Caruso R, Fina D, Peluso I, Fantini M, Tosti C, Del Vecchio Blanco G, et al. IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J Immunol. 2007;178:5957-65 pubmed
Monteleone G, Caruso R, Fina D, Peluso I, Gioia V, Stolfi C, et al. Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut. 2006;55:1774-80 pubmed
Djafarzadeh R, Noessner E, Engelmann H, Schendel D, Notohamiprodjo M, von Luettichau I, et al. GPI-anchored TIMP-1 treatment renders renal cell carcinoma sensitive to FAS-meditated killing. Oncogene. 2006;25:1496-508 pubmed
Wilson M, Jiang A, Wiehr C, Wang X, Sinha A, Pei D. Limited processing of pro-matrix metalloprotease-2 (gelatinase A) overexpressed by transfection in PC-3 human prostate tumor cells: association with restricted cell surface localization of membrane-type matrix metalloproteinase-1. J Androl. 2004;25:274-85 pubmed

product information

master code :

MAB970

SKU :

MAB970-100

product name :

Human TIMP-1 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human TIMP-1 Antibody from R&D Systems is a mouse monoclonal antibody to TIMP-1. This antibody reacts with human,primate. The Human TIMP-1 Antibody has been validated for the following applications: ELISA Capture,Cell-based ELISA,Luminex Development,Western Blot,Dot Blot,Mass Spectrometry,Immunocytochemistry,Immunohistochemistry,ELISA Capture (Matched Antibody Pair),Intracellular Staining by Flow Cytometry,CyTOF-ready.

target :

TIMP-1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

63515

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human TIMP-1, Cys24-Ala207, Accession # P01033

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Primate

specificity :

Detects human TIMP-1 in ELISAs and Western blots. In ELISAs, this antibody does not cross-react with recombinant mouse TIMP-1 or recombinant human TIMP-2.

gene symbol :

TIMP1

top caption :

TIMP-1 antibody in Wi-38 Human Cell Line by Immunocytochemistry (ICC).

accessionNumbers :

P01033

applications :

Cell-based ELISA,Luminex Development,Western Blot,Dot Blot,Mass Spectrometry,ELISA Capture,Immunocytochemistry,Immunohistochemistry,ELISA Capture (Matched Antibody Pair),Intracellular Staining by Flow Cytometry,CyTOF-ready

USD :

469 USD

alt names :

CLGI, Collagenase inhibitor, collagenase inhibitor), EPATIMP-1, EPO, erythroid potentiating activity, Erythroid-potentiating activity, Fibroblast collagenase inhibitor, FLJ90373, HCI, metalloproteinase inhibitor 1, TIMP metallopeptidase inhibitor 1, TIMP1, TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, Tissue inhibitor of metalloproteinases 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage