product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human DUX4/DUX4c Antibody
catalog :
MAB95351-100
quantity :
100 ug (also 25 ug)
price :
459 USD
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
2143C
application :
western blot, immunohistochemistry
more info or order :
R&D Systems product webpage
citations: 5
Reference
Campolungo D, Salom xe9 M, Biferali B, Tascini A, Gabellini D. DUX4-r exerts a neomorphic activity that depends on GTF2I in acute lymphoblastic leukemia. Sci Adv. 2023;9:eadi3771 pubmed publisher
Soliman H, Toso E, Darwish I, Ali S, Kyba M. Antiapoptotic Protein FAIM2 is targeted by miR-3202, and DUX4 via TRIM21, leading to cell death and defective myogenesis. Cell Death Dis. 2022;13:405 pubmed publisher
Bosnakovski D, Oyler D, Mitanoska A, Douglas M, Ener E, Shams A, et al. Persistent Fibroadipogenic Progenitor Expansion Following Transient DUX4 Expression Provokes a Profibrotic State in a Mouse Model for FSHD. Int J Mol Sci. 2022;23: pubmed publisher
Bosnakovski D, Shams A, Yuan C, da Silva M, Ener E, Baumann C, et al. Transcriptional and cytopathological hallmarks of FSHD in chronic DUX4-expressing mice. J Clin Invest. 2020;130:2465-2477 pubmed publisher
Lee J, Bosnakovski D, Toso E, Dinh T, Banerjee S, Bohl T, et al. Crystal Structure of the Double Homeodomain of DUX4 in Complex with DNA. Cell Rep. 2018;25:2955-2962.e3 pubmed publisher
product information
master code :
MAB95351
SKU :
MAB95351-100
product name :
Human DUX4/DUX4c Antibody
unit size :
100 ug (also 25 ug)
description :
The Human DUX4/DUX4c Antibody from R&D Systems is a rabbit monoclonal antibody to DUX4/DUX4c. This antibody reacts with human,mouse. The Human DUX4/DUX4c Antibody has been validated for the following applications: Western Blot,Immunohistochemistry.
target :
DUX4/DUX4c
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
2143C
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Human DUX4 synthetic peptide containing sequences within amino acids 200-300 of the human DUX4 protein, Accession # Q9UBX2
isotype :
IgG
purity :
Protein A or G purified from cell culture supernatant
species :
Human,Mouse
specificity :
Detects human DUX4/DUX4c in direct ELISAs.
top caption :
Detection of Human DUX4/DUX4c antibody by Western Blot.
accessionNumbers :
Q9UBX2
applications :
Western Blot,Immunohistochemistry
extended description :
Recombinant Monoclonal Antibody.
USD :
459 USD
product details :
Recombinant Monoclonal Antibody.
alt names :
DUX10, DUX4, DUX4L, DUX4L1, DUX4L9
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.