Mouse ADAM10 Ectodomain Antibody | R&D Systems MAB946-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse ADAM10 Ectodomain Antibody

catalog :

MAB946-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

139712

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - free floating section, western blot knockout validation

more info or order :

R&D Systems product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; loading ...; fig 1d immunohistochemistry - free floating section; mouse; loading ...; fig 1a	McMillan N, Kirschen G, Desai S, Xia E, Tsirka S, Aguirre A. ADAM10 facilitates rapid neural stem cell cycling and proper positioning within the subventricular zone niche via JAMC/RAP1Gap signaling. Neural Regen Res. 2022;17:2472-2483 pubmed publisher
	Murter B, Robinson S, Banerjee H, Lau L, Uche U, Szymczak Workman A, et al. Downregulation of PIK3IP1/TrIP on T cells is controlled by TCR signal strength, PKC, and metalloprotease-mediated cleavage. J Biol Chem. 2024;300:107930 pubmed publisher
	Mitsiadis T, Jimenez Rojo L, Balic A, Weber S, Saftig P, Pagella P. Adam10-dependent Notch signaling establishes dental epithelial cell boundaries required for enamel formation. iScience. 2022;25:105154 pubmed publisher
	Liu G, Abas O, Strickland A, Chen Y, Shi M. CXCR6+CD4+ T cells promote mortality during Trypanosoma brucei infection. PLoS Pathog. 2021;17:e1009968 pubmed publisher
	Boscher E, Goupil C, Petry S, Keraudren R, Loiselle A, Planel E, et al. MicroRNA-138 Overexpression Alters Aβ42 Levels and Behavior in Wildtype Mice. Front Neurosci. 2020;14:591138 pubmed publisher
	Seifert A, Düsterhöft S, Wozniak J, Koo C, Tomlinson M, Nuti E, et al. The metalloproteinase ADAM10 requires its activity to sustain surface expression. Cell Mol Life Sci. 2021;78:715-732 pubmed publisher
	Niven J, Madelon N, Page N, Caruso A, Harlé G, Lemeille S, et al. Macroautophagy in Dendritic Cells Controls the Homeostasis and Stability of Regulatory T Cells. Cell Rep. 2019;28:21-29.e6 pubmed publisher
	Seipold L, Damme M, Prox J, Rabe B, Kaspárek P, Sedlacek R, et al. Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein. Biochim Biophys Acta Mol Cell Res. 2017;1864:217-230 pubmed publisher
	Atapattu L, Saha N, Chheang C, Eissman M, Xu K, Vail M, et al. An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. J Exp Med. 2016;213:1741-57 pubmed publisher
	Altmeppen H, Prox J, Krasemann S, Puig B, Kruszewski K, Dohler F, et al. The sheddase ADAM10 is a potent modulator of prion disease. elife. 2015;4: pubmed publisher
	Accarias S, Lugo Villarino G, Foucras G, Neyrolles O, Boullier S, Tabouret G. Pyroptosis of resident macrophages differentially orchestrates inflammatory responses to Staphylococcus aureus in resistant and susceptible mice. Eur J Immunol. 2015;45:794-806 pubmed publisher
	Ridder K, Keller S, Dams M, Rupp A, Schlaudraff J, Del Turco D, et al. Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation. PLoS Biol. 2014;12:e1001874 pubmed publisher
	Padro C, Shawler T, Gormley M, Sanders V. Adrenergic regulation of IgE involves modulation of CD23 and ADAM10 expression on exosomes. J Immunol. 2013;191:5383-97 pubmed publisher
	Guy C, Vignali K, Temirov J, Bettini M, Overacre A, Smeltzer M, et al. Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat Immunol. 2013;14:262-70 pubmed publisher
	Glomski K, Monette S, Manova K, De Strooper B, Saftig P, Blobel C. Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures. Blood. 2011;118:1163-74 pubmed publisher
	Gough P, Garton K, Wille P, Rychlewski M, Dempsey P, Raines E. A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16. J Immunol. 2004;172:3678-85 pubmed

product information

master code :

MAB946

SKU :

MAB946-100

product name :

Mouse ADAM10 Ectodomain Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Mouse ADAM10 Ectodomain Antibody from R&D Systems is a rat monoclonal antibody to ADAM10. This antibody reacts with mouse,transgenic mouse. The Mouse ADAM10 Ectodomain Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry,Immunocytochemistry,CyTOF-ready.

target :

ADAM10

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

139712

conjugate :

Unconjugated

host :

Rat

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse ADAM10, Thr215-Glu673, Accession # O35598

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse,Transgenic Mouse

specificity :

Detects mouse ADAM10 in direct ELISAs and Western blots. In direct ELISAs, approximately 25% cross-reactivity with recombinant human (rh) rhADAM10 is observed and no cross-reactivity with rhADAM8, recombinant mouse (rm) ADAM9, rmADAM15, rhBACE, or rhTACE is observed.

gene symbol :

ADAM10

top caption :

Detection of Mouse ADAM10 by Western Blot

accessionNumbers :

O35598

applications :

Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry,Immunocytochemistry,CyTOF-ready

USD :

489 USD

alt names :

a disintegrin and metalloprotease domain 10, a disintegrin and metalloproteinase domain 10, AD10, ADAM 10, ADAM metallopeptidase domain 10, CD156c, CD156c antigen, CDw156, disintegrin and metalloproteinase domain-containing protein 10, EC 3.4.24, HsT18717, kuz, Kuzbanian, Kuzbanian protein homolog, MADM, MADMEC 3.4.24.81, Mammalian disintegrin-metalloprotease

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage