product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse SPARC Antibody
catalog :
MAB942
quantity :
500 ug (also 25 ug)
price :
579 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
124413
reactivity :
mouse
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 9
Reference
Yu L, Zheng Y, Liu B, Kang M, Millar J, Rhee D. Secreted protein acidic and rich in cysteine (SPARC) knockout mice have greater outflow facility. PLoS ONE. 2020;15:e0241294 pubmed publisher
Melouane A, Carbonell A, Yoshioka M, Puymirat J, St Amand J. Implication of SPARC in the modulation of the extracellular matrix and mitochondrial function in muscle cells. PLoS ONE. 2018;13:e0192714 pubmed publisher
Furman J, Sompol P, Kraner S, Pleiss M, Putman E, Dunkerson J, et al. Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury. J Neurosci. 2016;36:1502-15 pubmed publisher
Hidalgo M, Plaza C, Musteanu M, Illei P, Brachmann C, Heise C, et al. SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial. Clin Cancer Res. 2015;21:4811-8 pubmed publisher
Karikoski M, Marttila Ichihara F, Elima K, Rantakari P, Hollmén M, Kelkka T, et al. Clever-1/stabilin-1 controls cancer growth and metastasis. Clin Cancer Res. 2014;20:6452-64 pubmed publisher
Alvarez R, Musteanu M, Garcia Garcia E, Lopez Casas P, Megias D, Guerra C, et al. Stromal disrupting effects of nab-paclitaxel in pancreatic cancer. Br J Cancer. 2013;109:926-33 pubmed publisher
McCurdy S, Dai Q, Zhang J, Zamilpa R, Ramirez T, Dayah T, et al. SPARC mediates early extracellular matrix remodeling following myocardial infarction. Am J Physiol Heart Circ Physiol. 2011;301:H497-505 pubmed publisher
Socha M, Manhiani M, Said N, Imig J, Motamed K. Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension. Am J Pathol. 2007;171:1104-12 pubmed
Weaver M, Sage E, Yan Q. Absence of SPARC in lens epithelial cells results in altered adhesion and extracellular matrix production in vitro. J Cell Biochem. 2006;97:423-32 pubmed
product information
master code :
MAB942
SKU :
MAB942
product name :
Mouse SPARC Antibody
unit size :
500 ug (also 25 ug)
description :
The Mouse SPARC Antibody from R&D Systems is a rat monoclonal antibody to SPARC. This antibody reacts with mouse,rat,transgenic mouse. The Mouse SPARC Antibody has been validated for the following applications: Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Intracellular Staining by Flow Cytometry,CyTOF-ready.
target :
SPARC
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
124413
conjugate :
Unconjugated
host :
Rat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse SPARC/Osteonectin, Ala18-Ile302, Accession # P07214
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Mouse,Transgenic Mouse
specificity :
Detects mouse SPARC/Osteonectin in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human SPARC is observed.
gene symbol :
SPARC
top caption :
Detection of Mouse SPARC antibody by Western Blot.
accessionNumbers :
P07214
applications :
Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Intracellular Staining by Flow Cytometry,CyTOF-ready
USD :
579 USD
alt names :
Basement-membrane protein 40, BM-40, ONcysteine-rich protein, osteonectin, Secreted protein acidic and rich in cysteine, secreted protein, acidic, cysteine-rich (osteonectin)
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.