Mouse 4-1BB/TNFRSF9/CD137 Antibody | R&D Systems MAB9371-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse 4-1BB/TNFRSF9/CD137 Antibody

catalog :

MAB9371-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

158321

reactivity :

human, mouse

application :

neutralization

more info or order :

R&D Systems product webpage

citations: 6

Reference
Dodagatta Marri E, Ma H, Liang B, Li J, Meyer D, Chen S, et al. Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy. Cell Rep. 2021;36:109309 pubmed publisher
Ho S, Xu Z, Thakur A, Fox M, Tan S, DiGiammarino E, et al. Epitope and Fc-Mediated Cross-linking, but Not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver Toxicity. Mol Cancer Ther. 2020;19:1040-1051 pubmed publisher
Lu Y, Li C, Du S, Chen X, Zeng X, Liu F, et al. 4-1BB Signaling Promotes Alveolar Macrophages-Mediated Pro-Fibrotic Responses and Crystalline Silica-Induced Pulmonary Fibrosis in Mice. Front Immunol. 2018;9:1848 pubmed publisher
Escuin Ordinas H, Elliott M, Atefi M, Lee M, Ng C, Wei L, et al. PET imaging to non-invasively study immune activation leading to antitumor responses with a 4-1BB agonistic antibody. J Immunother Cancer. 2013;1:14 pubmed publisher
Wells J, Cowled C, Farzaneh F, Noble A. Combined triggering of dendritic cell receptors results in synergistic activation and potent cytotoxic immunity. J Immunol. 2008;181:3422-31 pubmed
Wu T, Xie C, Bhaskarabhatla M, Yan M, Leone A, Chen S, et al. Excreted urinary mediators in an animal model of experimental immune nephritis with potential pathogenic significance. Arthritis Rheum. 2007;56:949-59 pubmed

product information

brand :

R&D Systems

master code :

MAB9371

SKU :

MAB9371-100

product name :

Mouse 4-1BB/TNFRSF9/CD137 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Mouse 4-1BB/TNFRSF9/CD137 Antibody from R&D Systems is a rat monoclonal antibody to 4-1BB/TNFRSF9/CD137. This antibody reacts with mouse. The Mouse 4-1BB/TNFRSF9/CD137 Antibody has been validated for the following applications: In vivo assay,Agonist Activity,Control,Neutralization.

target :

4-1BB/TNFRSF9/CD137

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

158321

conjugate :

Unconjugated

dilution :

Agonist Activity

host :

Rat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse 4-1BB, Val24-Leu187, Accession # P20334

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse

specificity :

Detects mouse 4-1BB in direct ELISAs and Western blots. In direct ELISAs, this antibody shows no cross-reactivity with recombinant mouse (rm) BAFF R, rmCD27, rmCD30, rmCD40, rmDR3, rmEDAR, rmFas, rmGITR, rmLT▀R, rmNGF R, rmOPG, rmRANK, rmTAJ, rmTNF RI, rmTNF RII, rh4-1BB, rhDR6, or rhHVEM.

gene symbol :

TNFRSF9

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

accessionNumbers :

P20334

applications :

In vivo assay,Agonist Activity,Control,Neutralization

USD :

469 USD

alt names :

41BB, 4-1BB, 4-1BB ligand receptor, CD137, CD137 antigen, CD137MGC2172, CDw137, FLJ43501, ILA, ILAhomolog of mouse 4-1BB, induced by lymphocyte activation (ILA), interleukin-activated receptor, homolog of mouse Ly63, receptor protein 4-1BB, T cell antigen ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNFRSF9, tumor necrosis factor receptor superfamily member 9, tumor necrosis factor receptor superfamily, member 9

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage