product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Human/Hamster ACE-2 Antibody
catalog :
MAB933
quantity :
500 ug (also 25 ug)
price :
569 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
171606
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 59
Reference
Rau A, Schicht M, Zahn I, Ali M, Coroneo M, Paulsen F. Detection of SARS-CoV-2 binding receptors and miscellaneous targets as well as mucosal surface area of the human lacrimal drainage system. Ocul Surf. 2024;34:296-308 pubmed publisher
Alotaibi M, Al Hazani T, Alwaili M, Jalal A, Alshaya D, Safhi F, et al. SARS-CoV-2 virus associated angiotensin converting enzyme 2 expression modulation in colorectal cancer: Insights from mRNA and protein analysis COVID-19 associated (ACE2) expression in colorectal cancer. Microb Pathog. 2023;185:106389 pubmed publisher
Bouillet L, Deroux A, Benmarce M, Gu xe9 rin C, Bouvet L, Garnier O, et al. Molecular Mechanisms of Endothelialitis in SARS-CoV-2 Infection: Evidence for VE-Cadherin Cleavage by ACE2. Int J Mol Sci. 2023;24: pubmed publisher
Uppal S, Postnikova O, Villasmil R, Rogozin I, Bocharov A, Eggerman T, et al. Low-Density Lipoprotein Receptor (LDLR) Is Involved in Internalization of Lentiviral Particles Pseudotyped with SARS-CoV-2 Spike Protein in Ocular Cells. Int J Mol Sci. 2023;24: pubmed publisher
Fignani D, Pedace E, Licata G, Grieco G, Aiello E, De Luca C, et al. Angiotensin I-converting enzyme type 2 expression is increased in pancreatic islets of type 2 diabetic donors. Diabetes Metab Res Rev. 2023;39:e3696 pubmed publisher
Mitchell A, Yu C, Zhao X, Pearmain L, Shah R, Hanley K, et al. Rapid Generation of Pulmonary Organoids from Induced Pluripotent Stem Cells by Co-Culturing Endodermal and Mesodermal Progenitors for Pulmonary Disease Modelling. Biomedicines. 2023;11: pubmed publisher
Hernandez Lopez J, Hernandez Medina C, Medina Corvalan C, Rodenas M, Francisca A, Perez Garcia C, et al. Neuronal progenitors of the dentate gyrus express the SARS-CoV-2 cell receptor during migration in the developing human hippocampus. Cell Mol Life Sci. 2023;80:140 pubmed publisher
Ogawa K, Khan K, Koshiba A, Fujishita A, Horiguchi G, Teramukai S, et al. Association between tissue stress reaction and ACE2/TMPRSS2 expression in endometria of reproductive aged women before and during Covid-19 pandemic. BMC Womens Health. 2023;23:229 pubmed publisher
Liu D, Chen C, Chen D, Zhu A, Li F, Zhuang Z, et al. Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2. Proc Natl Acad Sci U S A. 2023;120:e2202820120 pubmed publisher
Jeong G, Kwon H, Ng W, Liu X, Moon H, Yoon G, et al. Ocular tropism of SARS-CoV-2 in animal models with retinal inflammation via neuronal invasion following intranasal inoculation. Nat Commun. 2022;13:7675 pubmed publisher
Deben C, Le Compte M, Siozopoulou V, Lambrechts H, Hermans C, Lau H, et al. Expression of SARS-CoV-2-Related Surface Proteins in Non-Small-Cell Lung Cancer Patients and the Influence of Standard of Care Therapy. Cancers (Basel). 2022;14: pubmed publisher
Torrens Mas M, Perell xf3 Reus C, Trias Ferrer N, Ibarg xfc en Gonz xe1 lez L, Cresp xed C, Galmes Panades A, et al. GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility. Front Cell Infect Microbiol. 2022;12:942951 pubmed publisher
Osan J, Talukdar S, Feldmann F, DeMontigny B, Jerome K, BAILEY K, et al. Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in Chronic Obstructive Pulmonary Disease. Microbiol Spectr. 2022;10:e0045922 pubmed publisher
Furstenberger M, Gallais F, Freudenberger S, Kessler R, Chenard M, Renaud Picard B. Atypical Unilateral SARS-CoV-2 Pneumonia in a Single Lung Re-Transplanted Patient: A Case Report. Transplant Proc. 2022;54:1564-1568 pubmed publisher
Richard D, Muthuirulan P, Aguiar J, Doxey A, Banerjee A, Mossman K, et al. Intronic regulation of SARS-CoV-2 receptor (ACE2) expression mediated by immune signaling and oxidative stress pathways. iScience. 2022;25:104614 pubmed publisher
Osman I, Garrec C, de Souza G, Zarubica A, Belhaouari D, Baudoin J, et al. Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19. Front Cell Infect Microbiol. 2022;12:798767 pubmed publisher
Br xe4 utigam K, Reinhard S, Galv xe1 n J, Wartenberg M, Hewer E, Sch xfc rch C. Systematic Investigation of SARS-CoV-2 Receptor Protein Distribution along Viral Entry Routes in Humans. Respiration. 2022;101:610-618 pubmed publisher
Beesley M, Davidson J, Panariello F, Shibuya S, Scaglioni D, Jones B, et al. COVID-19 and vertical transmission: assessing the expression of ACE2/TMPRSS2 in the human fetus and placenta to assess the risk of SARS-CoV-2 infection. BJOG. 2022;129:256-266 pubmed publisher
Panigrahi S, Goswami T, Ferrari B, Antonelli C, Bazdar D, Gilmore H, et al. SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis. Microbiol Spectr. 2021;9:e0073521 pubmed publisher
Fang L, Zhou L, Tamm M, Roth M. OM-85 Broncho-Vaxom®, a Bacterial Lysate, Reduces SARS-CoV-2 Binding Proteins on Human Bronchial Epithelial Cells. Biomedicines. 2021;9: pubmed publisher
Martin G, Wolf J, Lapp T, Agostini H, Schlunck G, Auw H xe4 drich C, et al. Viral S protein histochemistry reveals few potential SARS-CoV-2 entry sites in human ocular tissues. Sci Rep. 2021;11:19140 pubmed publisher
Munro M, Peng L, Wickremesekera S, Tan S. Colon adenocarcinoma-derived cells possessing stem cell function can be modulated using renin-angiotensin system inhibitors. PLoS ONE. 2021;16:e0256280 pubmed publisher
Sherman E, Emmer B. ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes. Sci Rep. 2021;11:15900 pubmed publisher
Pires de Souza G, Osman I, Le Bideau M, Baudoin J, Jaafar R, Devaux C, et al. Angiotensin II Receptor Blockers (ARBs Antihypertensive Agents) Increase Replication of SARS-CoV-2 in Vero E6 Cells. Front Cell Infect Microbiol. 2021;11:639177 pubmed publisher
Doyle M, Appleton A, Liu Q, Yao Q, Mazucanti C, Egan J. Human Type II Taste Cells Express Angiotensin-Converting Enzyme 2 and Are Infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Am J Pathol. 2021;191:1511-1519 pubmed publisher
Zheng J, MEYERHOLZ D, Wong L, Gelb M, Murakami M, Perlman S. Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D. J Clin Invest. 2021;131: pubmed publisher
Szekely L, Bozóky B, Bendek M, Ostad M, Lavignasse P, Haag L, et al. Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 death. Heliyon. 2021;7:e07134 pubmed publisher
Han M, Pandey D. ZMPSTE24 Regulates SARS-CoV-2 Spike Protein-enhanced Expression of Endothelial Plasminogen Activator Inhibitor-1. Am J Respir Cell Mol Biol. 2021;: pubmed publisher
Siljee S, Milne B, Brasch H, Bockett N, Patel J, Davis P, et al. Expression of Components of the Renin-Angiotensin System by Cancer Stem Cells in Renal Clear Cell Carcinoma. Biomolecules. 2021;11: pubmed publisher
Doyle M, Appleton A, Liu Q, Yao Q, Mazucanti C, Egan J. Human Taste Cells Express ACE2: a Portal for SARS-CoV-2 Infection. bioRxiv. 2021;: pubmed publisher
Caruso M, Distefano A, Emma R, Di Rosa M, Carota G, Rust S, et al. Role of Cigarette Smoke on Angiotensin-Converting Enzyme-2 Protein Membrane Expression in Bronchial Epithelial Cells Using an Air-Liquid Interface Model. Front Pharmacol. 2021;12:652102 pubmed publisher
Ma Y, Lu D, Bao L, Qu Y, Liu J, Qi X, et al. SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice. Animal Model Exp Med. 2021;4:2-15 pubmed publisher
Condor Capcha J, Lambert G, Dykxhoorn D, Salerno A, Hare J, Whitt M, et al. Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol. Front Cardiovasc Med. 2020;7:618651 pubmed publisher
Siljee S, Buchanan O, Brasch H, Bockett N, Patel J, Paterson E, et al. Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System. Cells. 2021;10: pubmed publisher
Riepler L, Rössler A, Falch A, Volland A, Borena W, Von Laer D, et al. Comparison of Four SARS-CoV-2 Neutralization Assays. Vaccines (Basel). 2020;9: pubmed publisher
Grajewski R, Rokohl A, Becker M, Paulsen F, Heindl L. Malignancy going viral: ACE2 and TMPRSS2 expression in conjunctival neoplastic diseases. Ann Anat. 2021;234:151661 pubmed publisher
Fignani D, Licata G, Brusco N, Nigi L, Grieco G, Marselli L, et al. SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature. Front Endocrinol (Lausanne). 2020;11:596898 pubmed publisher
Zang R, Case J, Yutuc E, Ma X, Shen S, Gomez Castro M, et al. Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Proc Natl Acad Sci U S A. 2020;117:32105-32113 pubmed publisher
Kusmartseva I, Wu W, Syed F, van der Heide V, Jorgensen M, Joseph P, et al. Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19. Cell Metab. 2020;32:1041-1051.e6 pubmed publisher
Osan J, Talukdar S, Feldmann F, Ann DeMontigny B, Jerome K, BAILEY K, et al. Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in COPD. bioRxiv. 2020;: pubmed publisher
Siljee S, Pilkington T, Brasch H, Bockett N, Patel J, Paterson E, et al. Cancer Stem Cells in Head and Neck Metastatic Malignant Melanoma Express Components of the Renin-Angiotensin System. Life (Basel). 2020;10: pubmed publisher
Katsura H, Sontake V, Tata A, Kobayashi Y, Edwards C, Heaton B, et al. Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction. Cell Stem Cell. 2020;27:890-904.e8 pubmed publisher
Lee I, Nakayama T, Wu C, Goltsev Y, Jiang S, Gall P, et al. ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs. Nat Commun. 2020;11:5453 pubmed publisher
Ortiz M, Thurman A, Pezzulo A, Leidinger M, Klesney Tait J, Karp P, et al. Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract. EBioMedicine. 2020;60:102976 pubmed publisher
Inde Z, Yapp C, Joshi G, Spetz J, Fraser C, Deskin B, et al. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity. bioRxiv. 2020;: pubmed publisher
Descamps G, Verset L, Trelcat A, Hopkins C, Lechien J, Journe F, et al. ACE2 Protein Landscape in the Head and Neck Region: The Conundrum of SARS-CoV-2 Infection. Biology (Basel). 2020;9: pubmed publisher
Hikmet F, M xe9 ar L, Edvinsson x, Micke P, Uhl xe9 n M, Lindskog C. The protein expression profile of ACE2 in human tissues. Mol Syst Biol. 2020;16:e9610 pubmed publisher
Aguiar J, Tremblay B, Mansfield M, Woody O, Lobb B, Banerjee A, et al. Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue. Eur Respir J. 2020;56: pubmed publisher
Sun J, Zhuang Z, Zheng J, Li K, Wong R, Liu D, et al. Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment. Cell. 2020;182:734-743.e5 pubmed publisher
Ortiz Bezara M, Thurman A, Pezzulo A, Leidinger M, Klesney Tait J, Karp P, et al. Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract. bioRxiv. 2020;: pubmed publisher
Lee I, Nakayama T, Wu C, Goltsev Y, Jiang S, Gall P, et al. Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers. medRxiv. 2020;: pubmed publisher
Grajewski R, Rokohl A, Becker M, Dewald F, Lehmann C, F xe4 tkenheuer G, et al. A missing link between SARS-CoV-2 and the eye?: ACE2 expression on the ocular surface. J Med Virol. 2021;93:78-79 pubmed publisher
Lange C, Wolf J, Auw Haedrich C, Schlecht A, Boneva S, Lapp T, et al. Expression of the COVID-19 receptor ACE2 in the human conjunctiva. J Med Virol. 2020;92:2081-2086 pubmed publisher
Yamaguchi M, Hirai S, Sumi T, Tanaka Y, Tada M, Nishii Y, et al. Angiotensin-converting enzyme 2 is a potential therapeutic target for EGFR-mutant lung adenocarcinoma. Biochem Biophys Res Commun. 2017;487:613-618 pubmed publisher
Heurich A, Hofmann Winkler H, Gierer S, Liepold T, Jahn O, Pohlmann S. TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. J Virol. 2014;88:1293-307 pubmed publisher
Iwata M, Silva Enciso J, Greenberg B. Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor alpha-converting enzyme. Am J Physiol Cell Physiol. 2009;297:C1318-29 pubmed publisher
Lovren F, Pan Y, Quan A, Teoh H, Wang G, Shukla P, et al. Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. Am J Physiol Heart Circ Physiol. 2008;295:H1377-84 pubmed publisher
Mizutani T, Fukushi S, Saijo M, Kurane I, Morikawa S. JNK and PI3k/Akt signaling pathways are required for establishing persistent SARS-CoV infection in Vero E6 cells. Biochim Biophys Acta. 2005;1741:4-10 pubmed
Hofmann H, Geier M, Marzi A, Krumbiegel M, Peipp M, Fey G, et al. Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor. Biochem Biophys Res Commun. 2004;319:1216-21 pubmed
product information
brand :
R&D Systems
master code :
MAB933
SKU :
MAB933
product name :
Human/Hamster ACE-2 Antibody
unit size :
500 ug (also 25 ug)
seo description :
The Human/Hamster ACE-2 Antibody from R&D Systems is a mouse monoclonal antibody to ACE-2. This antibody reacts with hamster,human,mouse,primate - chlorocebus aethiops (african green monkey). The Human/Hamster ACE-2 Antibody has been validated for the following applications: Immunocytochemistry,Western Blot,IHC/IF,Flow Cytometry,Functional Assay,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence.
target :
ACE-2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
171606
conjugate :
Unconjugated
dilution :
Western Blot 2 ug/mL, Immunohistochemistry 8-25 ug/mL
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human ACE-2, Gln18-Ser740 (predicted), Accession # Q9BYF1
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Hamster,Human,Mouse,Primate - Chlorocebus aethiops (African Green Monkey)
specificity :
Detects human ACE-2 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) ACE-1 or rhNeprilysin is observed.
gene symbol :
ACE2
top caption :
Detection of Human ACE-2 antibody by Western Blot.
accessionNumbers :
Q9BYF1
applications :
IHC/IF,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Functional Assay,Immunocytochemistry/ Immunofluorescence
USD :
569 USD
alt names :
ACE2, ACEH, ACEHangiotensin I converting enzyme 2, ACE-related carboxypeptidase, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, angiotensin-converting enzyme 2, Angiotensin-converting enzyme homolog, DKFZp434A014, EC 3.4.17, EC 3.4.17.23, Metalloprotease MPROT15
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.