Human/Mouse BACE-1 Ectodomain Antibody | R&D Systems MAB9311 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse BACE-1 Ectodomain Antibody

catalog :

MAB9311

quantity :

100 ug (also 25 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

137626

reactivity :

human, mouse

application :

western blot, neutralization, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 8

Reference
Dey J, Roberts A, Mahari S, Gandhi S, Tripathi P. Electrochemical Detection of Alzheimer's Disease Biomarker, β-Secretase Enzyme (BACE1), With One-Step Synthesized Reduced Graphene Oxide. Front Bioeng Biotechnol. 2022;10:873811 pubmed publisher
Hampel H, Lista S, Vanmechelen E, Zetterberg H, Giorgi F, Galgani A, et al. β-Secretase1 biological markers for Alzheimer's disease: state-of-art of validation and qualification. Alzheimers Res Ther. 2020;12:130 pubmed publisher
Liu L, Ding L, Rovere M, Wolfe M, Selkoe D. A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor. J Cell Biol. 2019;218:644-663 pubmed publisher
Liebsch F, Aurousseau M, Bethge T, McGuire H, Scolari S, Herrmann A, et al. Full-length cellular ?-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization. J Biol Chem. 2017;292:13258-13270 pubmed publisher
Tanokashira D, Motoki K, Minegishi S, Hosaka A, Mamada N, Tamaoka A, et al. LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking. Eneuro. 2015;2: pubmed publisher
Motoki K, Kume H, Oda A, Tamaoka A, Hosaka A, Kametani F, et al. Neuronal ?-amyloid generation is independent of lipid raft association of ?-secretase BACE1: analysis with a palmitoylation-deficient mutant. Brain Behav. 2012;2:270-82 pubmed publisher
Gonzales A, Decourt B, Walker A, Condjella R, Nural H, Sabbagh M. Development of a specific ELISA to measure BACE1 levels in human tissues. J Neurosci Methods. 2011;202:70-6 pubmed publisher
Costantini C, Ko M, Jonas M, Puglielli L. A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1. Biochem J. 2007;407:383-95 pubmed

product information

master code :

MAB9311

SKU :

MAB9311

product name :

Human/Mouse BACE-1 Ectodomain Antibody

unit size :

100 ug (also 25 ug)

description :

The Human/Mouse BACE-1 Ectodomain Antibody from R&D Systems is a mouse monoclonal antibody to BACE-1. This antibody reacts with human,mouse,n/a. The Human/Mouse BACE-1 Ectodomain Antibody has been validated for the following applications: Immunoprecipitation,Immunocytochemistry,Western Blot,ELISA Capture,ELISA Detection,Complex Application,Neutralization.

target :

BACE-1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

137626

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human BACE-1, Thr22-Tyr460, Accession # P56817

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,N/A

specificity :

Detects human and mouse BACE-1 Ectodomain in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) BACE-2, recombinant mouse BACE-2, rhADAM8, rhADAM9, rhADAM10, rhADAM15, or rhTACE is observed.

gene symbol :

BACE1

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Neutralization of BACE-1 Activity by Human/Mouse BACE-1 Antibody.

accessionNumbers :

P56817

applications :

Complex Application,Immunoprecipitation,Western Blot,Neutralization

USD :

469 USD

alt names :

APP beta-secretase, ASP2, Aspartyl protease 2, BACE1, BACEAsp 2, beta-secretase 1, beta-secretase 1 precursor variant 1, beta-site amyloid beta A4 precursor protein-cleaving enzyme, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, beta-site APP-cleaving enzyme, beta-site APP-cleaving enzyme 1, EC 3.4.23, EC 3.4.23.46, FLJ90568, HSPC104, KIAA1149, Memapsin-2, Membrane-associated aspartic protease 2, transmembrane aspartic proteinase Asp2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage