product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse BACE-1 Ectodomain Antibody
catalog :
MAB931-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
459 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
137612
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 15
Reference
Sawa M, OVERK C, Becker A, Derse D, Albay R, Weldy K, et al. Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model. Alzheimers Dement. 2022;18:1203-1234 pubmed publisher
Khan M, Shin J, Kim M, Shin T, Kim J. Green Tea Seed Isolated Theasaponin E1 Ameliorates AD Promoting Neurotoxic Pathogenesis by Attenuating Aβ Peptide Levels in SweAPP N2a Cells. Molecules. 2020;25: pubmed publisher
Wang J, Wuethrich A, Sina A, Lane R, Lin L, Wang Y, et al. Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma. Sci Adv. 2020;6:eaax3223 pubmed publisher
Mendsaikhan A, Tooyama I, Bellier J, Serrano G, Sue L, Lue L, et al. Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology. Acta Neuropathol Commun. 2019;7:215 pubmed publisher
Shen Y, Wang H, Sun Q, Yao H, Keegan A, Mullan M, et al. Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment. Biol Psychiatry. 2018;83:447-455 pubmed publisher
Schnöder L, Hao W, Qin Y, Liu S, Tomic I, Liu X, et al. Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1. J Biol Chem. 2016;291:2067-79 pubmed publisher
Wang Y, Thinakaran G, Kar S. Overexpression of the IGF-II/M6P receptor in mouse fibroblast cell lines differentially alters expression profiles of genes involved in Alzheimer's disease-related pathology. PLoS ONE. 2014;9:e98057 pubmed publisher
Cheng X, He P, Lee T, Yao H, Li R, Shen Y. High activities of BACE1 in brains with mild cognitive impairment. Am J Pathol. 2014;184:141-7 pubmed publisher
He P, Li P, Hua Q, Liu Y, Staufenbiel M, Li R, et al. Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces amyloidogenic processing of amyloid precursor protein in a mouse model of Alzheimer's disease. PLoS ONE. 2013;8:e58181 pubmed publisher
He P, Cheng X, Staufenbiel M, Li R, Shen Y. Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of ?-secretase in a mouse model of Alzheimer's disease. PLoS ONE. 2013;8:e55091 pubmed publisher
Gonzales A, Decourt B, Walker A, Condjella R, Nural H, Sabbagh M. Development of a specific ELISA to measure BACE1 levels in human tissues. J Neurosci Methods. 2011;202:70-6 pubmed publisher
Wang Y, Wang X, Lu J, Li Q, Gao C, Liu X, et al. p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain. J Neurosci. 2011;31:2292-304 pubmed publisher
Murphy M, Morales J, Beckett T, Astarita G, Piomelli D, Weidner A, et al. Changes in cognition and amyloid-? processing with long term cholesterol reduction using atorvastatin in aged dogs. J Alzheimers Dis. 2010;22:135-50 pubmed publisher
Pop V, Head E, Berchtold N, Glabe C, Studzinski C, Weidner A, et al. Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiol Aging. 2012;33:108-20 pubmed publisher
Ahmed R, Holler C, Webb R, Li F, Beckett T, Murphy M. BACE1 and BACE2 enzymatic activities in Alzheimer's disease. J Neurochem. 2010;112:1045-53 pubmed publisher
product information
master code :
MAB931
SKU :
MAB931-100
product name :
Human/Mouse BACE-1 Ectodomain Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human/Mouse BACE-1 Ectodomain Antibody from R&D Systems is a mouse monoclonal antibody to BACE-1. This antibody reacts with canine,human,mouse,n/a,rat. The Human/Mouse BACE-1 Ectodomain Antibody has been validated for the following applications: Western Blot,ELISA Capture,ELISA Detection,ELISA Development,Immunoprecipitation,Immunohistochemistry,Immunohistochemistry-Frozen,Intracellular Staining by Flow Cytometry,CyTOF-ready.
target :
BACE-1
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
137612
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human BACE-1, Thr22-Tyr460, Accession # P56817
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Rat
specificity :
Detects human and mouse BACE-1 in direct ELISAs and human BACE-1 in Western blots. In Western blots, no cross-reactivity with recombinant human (rh) BACE-2, recombinant mouse (rm) BACE-2, rhADAM8, rmADAM9, rmADAM10, rhADAM15, or rhTACE is observed.
gene symbol :
BACE1
top caption :
Detection of Human BACE-1 antibody by Western Blot.
accessionNumbers :
P56817
applications :
ELISA Development,Immunoprecipitation,Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen,Intracellular Staining by Flow Cytometry,CyTOF-ready
USD :
459 USD
alt names :
APP beta-secretase, ASP2, Aspartyl protease 2, BACE1, BACEAsp 2, beta-secretase 1, beta-secretase 1 precursor variant 1, beta-site amyloid beta A4 precursor protein-cleaving enzyme, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, beta-site APP-cleaving enzyme, beta-site APP-cleaving enzyme 1, EC 3.4.23, EC 3.4.23.46, FLJ90568, HSPC104, KIAA1149, Memapsin-2, Membrane-associated aspartic protease 2, transmembrane aspartic proteinase Asp2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.