Human TACE/ADAM17 Ectodomain Antibody | R&D Systems MAB9301 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TACE/ADAM17 Ectodomain Antibody

catalog :

MAB9301

quantity :

100 ug (also 25 ug, 500 ug)

price :

359 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

111633

reactivity :

human

application :

western blot, immunoprecipitation, flow cytometry

citations: 10

Reference
Raneros A, Puras A, Rodriguez R, Colado E, Bernal T, Anguita E, et al. Increasing TIMP3 expression by hypomethylating agents diminishes soluble MICA, MICB and ULBP2 shedding in acute myeloid leukemia, facilitating NK cell-mediated immune recognition. Oncotarget. 2017;8:31959-31976 pubmed publisher
Buchanan P, Boylan K, Walcheck B, Heinze R, Geller M, Argenta P, et al. Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17. J Biol Chem. 2017;292:6339-6351 pubmed publisher
Zingoni A, Cecere F, Vulpis E, Fionda C, Molfetta R, Soriani A, et al. Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells. J Immunol. 2015;195:736-48 pubmed publisher
Jing Y, Ni Z, Wu J, Higgins L, Markowski T, Kaufman D, et al. Identification of an ADAM17 cleavage region in human CD16 (FcÎ³RIII) and the engineering of a non-cleavable version of the receptor in NK cells. PLoS ONE. 2015;10:e0121788 pubmed publisher
Garbin U, Baggio E, Stranieri C, Pasini A, Manfro S, Mozzini C, et al. Expansion of necrotic core and shedding of Mertk receptor in human carotid plaques: a role for oxidized polyunsaturated fatty acids?. Cardiovasc Res. 2013;97:125-33 pubmed publisher
Breshears L, Schlievert P, Peterson M. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). J Biol Chem. 2012;287:32578-87 pubmed
Gutierrez Lopez M, Gilsanz A, Yanez Mo M, Ovalle S, Lafuente E, Dominguez C, et al. The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9. Cell Mol Life Sci. 2011;68:3275-92 pubmed publisher
Villeneuve J, Block A, Le Bousse Kerdiles M, Lepreux S, Nurden P, Ripoche J, et al. Tissue inhibitors of matrix metalloproteinases in platelets and megakaryocytes: a novel organization for these secreted proteins. Exp Hematol. 2009;37:849-56 pubmed publisher
Hurst L, Bunning R, Couraud P, Romero I, Weksler B, Sharrack B, et al. Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment. J Neuroimmunol. 2009;210:108-12 pubmed publisher
Koenen R, Pruessmeyer J, Soehnlein O, Fraemohs L, Zernecke A, Schwarz N, et al. Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases. Blood. 2009;113:4799-809 pubmed publisher

product information

brand :

R&D Systems

master code :

MAB9301

SKU :

MAB9301-100

product name :

Human TACE/ADAM17 Ectodomain Antibody

description :

The Human TACE/ADAM17 Ectodomain Antibody from R&D Systems is a mouse monoclonal antibody to TACE/ADAM17. This antibody reacts with human. The Human TACE/ADAM17 Ectodomain Antibody has been validated for the following applications: Western Blot, Flow Cytometry, Immunoprecipitation, CyTOF-ready, Knockout Validated.

target :

TACE/ADAM17

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

111633

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

Insect ovarian cell line T. ni -derived recombinant human TACE/ADAM17, Pro18-Asn671, Accession # P78536

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects the ectodomain of human TACE/ADAM17 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with the ectodomain of recombinant human ADAM8, 9, 15 and recombinant mouse ADAM10 is observed.

gene symbol :

ADAM17

details of functionality :

ActivityAssaywCitation not found None None None None

catalog number base :

MAB9301

accessionNumbers :

P78536

applications :

Western Blot, Flow Cytometry, Immunoprecipitation, CyTOF-ready, Knockout Validated

2020 USD :

339

2021 USD :

359 USD

alt names :

ADAM 17, ADAM metallopeptidase domain 17, ADAM metallopeptidase domain 18, ADAM17, ADAM18, CD156b, CD156b antigen, CSVP, disintegrin and metalloproteinase domain-containing protein 17, EC 3.4.24.86, MGC71942, Snake venom-like protease, TACEcSVP, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha-converting enzyme, tumor necrosis factor, alpha, converting enzyme

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.