Human MMP-14/MT1-MMP Antibody | R&D Systems MAB9181-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human MMP-14/MT1-MMP Antibody

catalog :

MAB9181-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

128527

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 11

Reference
Gerwinn T, Salemi S, Schori L, Planta D, Eberli D, Horst M. Improved contractile potential in detrusor microtissues from pediatric patients with end stage lower urinary tract dysfunction. Front Cell Dev Biol. 2022;10:1007265 pubmed publisher
Parveen S, Khamari A, Raju J, Coppolino M, Datta S. Syntaxin 7 contributes to breast cancer cell invasion by promoting invadopodia formation. J Cell Sci. 2022;135: pubmed publisher
Layton T, Williams L, Yang N, Zhang M, Lee C, Feldmann M, et al. A vasculature niche orchestrates stromal cell phenotype through PDGF signaling: Importance in human fibrotic disease. Proc Natl Acad Sci U S A. 2022;119:e2120336119 pubmed publisher
Takenaga K, Ochiya T, Endo H. Inhibition of the invasion and metastasis of mammary carcinoma cells by NBD peptide targeting S100A4 via the suppression of the Sp1/MMP‑14 axis. Int J Oncol. 2021;58:397-408 pubmed publisher
Layton T, Williams L, McCann F, Zhang M, Fritzsche M, Colin York H, et al. Cellular census of human fibrosis defines functionally distinct stromal cell types and states. Nat Commun. 2020;11:2768 pubmed publisher
Morgan R, Behbahani Nejad N, Endres J, Amin M, Lepore N, Du Y, et al. Localization, Shedding, Regulation and Function of Aminopeptidase N/CD13 on Fibroblast like Synoviocytes. PLoS ONE. 2016;11:e0162008 pubmed publisher
Kajiho H, Kajiho Y, Frittoli E, Confalonieri S, Bertalot G, Viale G, et al. RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs. EMBO Rep. 2016;17:1061-80 pubmed publisher
Kaimal R, Aljumaily R, Tressel S, Pradhan R, Covic L, Kuliopulos A, et al. Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis, and tumor growth in ovarian cancer. Cancer Res. 2013;73:2457-2467 pubmed publisher
Mierke C, Bretz N, Altevogt P. Contractile forces contribute to increased glycosylphosphatidylinositol-anchored receptor CD24-facilitated cancer cell invasion. J Biol Chem. 2011;286:34858-71 pubmed publisher
Mierke C, Frey B, Fellner M, Herrmann M, Fabry B. Integrin ?5?1 facilitates cancer cell invasion through enhanced contractile forces. J Cell Sci. 2011;124:369-83 pubmed publisher
Djafarzadeh R, Noessner E, Engelmann H, Schendel D, Notohamiprodjo M, von Luettichau I, et al. GPI-anchored TIMP-1 treatment renders renal cell carcinoma sensitive to FAS-meditated killing. Oncogene. 2006;25:1496-508 pubmed

product information

master code :

MAB9181

SKU :

MAB9181-100

product name :

Human MMP-14/MT1-MMP Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human MMP-14/MT1-MMP Antibody from R&D Systems is a mouse monoclonal antibody to MMP-14/MT1-MMP. This antibody reacts with human. The Human MMP-14/MT1-MMP Antibody has been validated for the following applications: Western Blot,Immunocytochemistry,CyTof,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Frozen,Immunoprecipitation,CyTOF-ready.

target :

MMP-14/MT1-MMP

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

128527

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human MMP-14/MT1-MMP, Tyr112-Ala541 (predicted), Accession # P50281

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human MMP-14/MT1-MMP in direct ELISAs and Western blots. Does not detect E. coli -expressed recombinant human MMP-14 catalytic domain (aa 112-284).

gene symbol :

MMP14

top caption :

Detection of MMP-14/MT1-MMP antibody in MDA-MB-231 Human Cell Line antibody by Flow Cytometry.

accessionNumbers :

P50281

applications :

Immunocytochemistry,CyTof,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Frozen,Immunoprecipitation,Western Blot,CyTOF-ready

USD :

469 USD

alt names :

EC 3.4.24, EC 3.4.24.80, matrix metallopeptidase 14 (membrane-inserted), matrix metalloproteinase 14 (membrane-inserted), matrix metalloproteinase-14, membrane type 1 metalloprotease, Membrane-type matrix metalloproteinase 1, Membrane-type-1 matrix metalloproteinase, MMP14, MMP-14, MMP-X1, MT1MMP, MT1-MMP, MT1-MMPMTMMP1, MT-MMP 1, MT-MMP1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage