product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Phospho-Smad2/3 (S465/S467) Antibody
catalog :
MAB8935
quantity :
100 ug (also 25 ug)
price :
459 USD
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
1074A
reactivity :
human, mouse
application :
western blot, immunocytochemistry, chromatin immunoprecipitation
more info or order :
R&D Systems product webpage
citations: 11
Reference
Yoshida M, Kokubun T, Sato K, Tsuda S, Yokoyama Y, Himori N, et al. DPP-4 Inhibitors Attenuate Fibrosis After Glaucoma Filtering Surgery by Suppressing the TGF-β/Smad Signaling Pathway. Invest Ophthalmol Vis Sci. 2023;64:2 pubmed publisher
Passanha F, Geuens T, LaPointe V. Cadherin-11 influences differentiation in human mesenchymal stem cells by regulating the extracellular matrix via the TGFβ1 pathway. Stem Cells. 2022;: pubmed publisher
Lombardi F, Augello F, Palumbo P, Mollsi E, Giuliani M, Cimini A, et al. Soluble Fraction from Lysate of a High Concentration Multi-Strain Probiotic Formulation Inhibits TGF-β1-Induced Intestinal Fibrosis on CCD-18Co Cells. Nutrients. 2021;13: pubmed publisher
Ahuja N, Ashok C, Natua S, Pant D, Cherian A, Pandkar M, et al. Hypoxia-induced TGF-β-RBFOX2-ESRP1 axis regulates human MENA alternative splicing and promotes EMT in breast cancer. NAR Cancer. 2020;2:zcaa021 pubmed publisher
Halder L, Jo E, Hasan M, Ferreira Gomes M, Krüger T, Westermann M, et al. Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles. Nat Commun. 2020;11:2331 pubmed publisher
Vijayaraj P, Minasyan A, Durra A, Karumbayaram S, Mehrabi M, Aros C, et al. Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. Cell Rep. 2019;29:3488-3505.e9 pubmed publisher
Zhou S, da Silva S, Siegel P, Philip A. CD109 acts as a gatekeeper of the epithelial trait by suppressing epithelial to mesenchymal transition in squamous cell carcinoma cells in vitro. Sci Rep. 2019;9:16317 pubmed publisher
Tan J, Wang Y, Wang S, Wu S, Yuan Z, Zhu X. Label-free quantitative proteomics identifies transforming growth factor β1 (TGF-β1) as an inhibitor of adipogenic transformation in OP9-DL1 cells and primary thymic stromal cells. Cell Biosci. 2019;9:48 pubmed publisher
Nakai K, Karita S, Igarashi J, Tsukamoto I, Hirano K, Kubota Y. COA-Cl prevented TGF-β1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis. J Dermatol Sci. 2019;94:205-212 pubmed publisher
Wang Y, Wang X, Zhou X, Zhu Z, Yang J, Liu F. Suppressive effect mediated by human adipose-derived stem cells on T cells involves the activation of JNK. Int J Mol Med. 2019;43:177-184 pubmed publisher
Cheng T, Yue M, Aslam M, Wang X, Shekhawat G, Varani J, et al. Neuronal Protein 3.1 Deficiency Leads to Reduced Cutaneous Scar Collagen Deposition and Tensile Strength due to Impaired Transforming Growth Factor-β1 to -β3 Translation. Am J Pathol. 2017;187:292-303 pubmed publisher
product information
master code :
MAB8935
SKU :
MAB8935
product name :
Human Phospho-Smad2/3 (S465/S467) Antibody
unit size :
100 ug (also 25 ug)
description :
The Human Phospho-Smad2/3 (S465/S467) Antibody from R&D Systems is a rabbit monoclonal antibody to Smad2/3. This antibody reacts with human,mouse. The Human Phospho-Smad2/3 (S465/S467) Antibody has been validated for the following applications: ChIP (chromatin immunoprecipit,Western Blot,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry.
target :
Smad2/3
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
1074A
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Phosphopeptide containing the human Smad2 S465/S467 site, Accession # NP_005892
isotype :
IgG
purity :
Protein A or G purified from cell culture supernatant
species :
Human,Mouse
specificity :
Detects human Smad2 and Smad3 when dually phosphorylated at S465 and S467 in Western blots.
top caption :
Detection of Human Phospho-Smad2/3 (S465/S467) antibody by Western Blot.
accessionNumbers :
NP_005892
applications :
ChIP (chromatin immunoprecipit,Western Blot,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry
extended description :
Recombinant Monoclonal Antibody.
USD :
459 USD
product details :
Recombinant Monoclonal Antibody.
alt names :
hMAD-2, hSMAD2, JV18, JV18-1, JV18-1SMAD, mothers against DPP homolog 2 (Drosophila), MAD homolog 2, Mad protein homolog, Mad, mothers against decapentaplegic homolog 2, MADH2, MADH2MGC34440, MADR2, MADR2MGC22139, Mad-related protein 2, mother against DPP homolog 2, mothers against decapentaplegic homolog 2, Mothers against DPP homolog 2, Sma- and Mad-related protein 2, SMAD 2, SMAD family member 2MAD, mothers against decapentaplegic homolog 2 (Drosophila), SMAD, mothers against DPP homolog 2, Smad2, Smox
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.