Human Mer Antibody | R&D Systems MAB8912-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Mer Antibody

catalog :

MAB8912-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

539 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

125518

reactivity :

human

application :

western blot, ELISA, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 25

Reference
Dorion M, Casas D, Shlaifer I, Yaqubi M, Fleming P, Karpilovsky N, et al. An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders. Mol Neurodegener. 2024;19:31 pubmed publisher
Summers R, Jain J, Vasileiadi E, Smith B, Chimenti M, Yeung T, et al. Therapeutic Targeting of MERTK and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia. Cancers (Basel). 2022;14: pubmed publisher
Powell R, Peeters M, Rahbech A, Aehnlich P, Seremet T, thor Straten P. Small Molecule Inhibitors of MERTK and FLT3 Induce Cell Cycle Arrest in Human CD8+ T Cells. Vaccines (Basel). 2021;9: pubmed publisher
Zheng H, Zhao J, Li B, Zhang W, Stashko M, Minson K, et al. UNC5293, a potent, orally available and highly MERTK-selective inhibitor. Eur J Med Chem. 2021;220:113534 pubmed publisher
Rios Doria J, Favata M, Lasky K, Feldman P, Lo Y, Yang G, et al. A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity. Front Oncol. 2020;10:598477 pubmed publisher
McDaniel N, Cummings C, Iida M, Hulse J, Pearson H, Vasileiadi E, et al. MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents. Mol Cancer Ther. 2018;17:2297-2308 pubmed publisher
Sander J, Schmidt S, Cirovic B, McGovern N, Papantonopoulou O, Hardt A, et al. Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. Immunity. 2017;47:1051-1066.e12 pubmed publisher
Branchford B, Stalker T, Law L, Acevedo G, Sather S, Brzezinski C, et al. The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis. J Thromb Haemost. 2017;: pubmed publisher
Bernsmeier C, Triantafyllou E, Brenig R, Lebosse F, Singanayagam A, Patel V, et al. CD14+ CD15- HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure. Gut. 2018;67:1155-1167 pubmed publisher
Pagani I, Ghezzi S, Ulisse A, Rubio A, Turrini F, Garavaglia E, et al. Human Endometrial Stromal Cells Are Highly Permissive To Productive Infection by Zika Virus. Sci Rep. 2017;7:44286 pubmed publisher
Minson K, Smith C, DeRyckere D, Libbrecht C, Lee Sherick A, Huey M, et al. The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia. JCI Insight. 2016;1:e85630 pubmed publisher
Happonen K, Tran S, MÃ¶rgelin M, Prince R, Calzavarini S, Angelillo Scherrer A, et al. The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles. J Biol Chem. 2016;291:10586-601 pubmed publisher
Cummings C, Zhang W, Davies K, Kirkpatrick G, Zhang D, DeRyckere D, et al. Small Molecule Inhibition of MERTK Is Efficacious in Non-Small Cell Lung Cancer Models Independent of Driver Oncogene Status. Mol Cancer Ther. 2015;14:2014-22 pubmed publisher
Cummings C, Linger R, Cohen R, Sather S, Kirkpatrick G, Davies K, et al. Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer. Oncotarget. 2014;5:10434-45 pubmed
Zhang W, DeRyckere D, Hunter D, Liu J, Stashko M, Minson K, et al. UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor. J Med Chem. 2014;57:7031-41 pubmed publisher
Knubel K, Pernu B, Sufit A, Nelson S, Pierce A, Keating A. MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme. Oncotarget. 2014;5:1338-51 pubmed
Zhang W, McIver A, Stashko M, DeRyckere D, Branchford B, Hunter D, et al. Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem. 2013;56:9693-700 pubmed publisher
Zhang W, Zhang D, Stashko M, DeRyckere D, Hunter D, Kireev D, et al. Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J Med Chem. 2013;56:9683-92 pubmed publisher
Christoph S, DeRyckere D, Schlegel J, Frazer J, Batchelor L, Trakhimets A, et al. UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Mol Cancer Ther. 2013;12:2367-77 pubmed publisher
Liu J, Zhang W, Stashko M, DeRyckere D, Cummings C, Hunter D, et al. UNC1062, a new and potent Mer inhibitor. Eur J Med Chem. 2013;65:83-93 pubmed publisher
Schlegel J, Sambade M, Sather S, Moschos S, Tan A, Winges A, et al. MERTK receptor tyrosine kinase is a therapeutic target in melanoma. J Clin Invest. 2013;123:2257-67 pubmed publisher
Bauer T, Zagorska A, Jurkin J, Yasmin N, Köffel R, Richter S, et al. Identification of Axl as a downstream effector of TGF-?1 during Langerhans cell differentiation and epidermal homeostasis. J Exp Med. 2012;209:2033-47 pubmed publisher
Linger R, Cohen R, Cummings C, Sather S, Migdall Wilson J, Middleton D, et al. Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer. Oncogene. 2013;32:3420-31 pubmed publisher
Hurtado B, Munoz X, Recarte Pelz P, Garcia N, Luque A, Krupinski J, et al. Expression of the vitamin K-dependent proteins GAS6 and protein S and the TAM receptor tyrosine kinases in human atherosclerotic carotid plaques. Thromb Haemost. 2011;105:873-82 pubmed publisher
Shiozawa Y, Pedersen E, Taichman R. GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. Exp Hematol. 2010;38:132-40 pubmed publisher

product information

master code :

MAB8912

SKU :

MAB8912-100

product name :

Human Mer Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human Mer Antibody from R&D Systems is a mouse monoclonal antibody to Mer. This antibody reacts with human. The Human Mer Antibody has been validated for the following applications: Immunoprecipitation,Western Blot,Flow Cytometry,Immunohistochemistry-Paraffin,ELISA Capture (Matched Antibody Pair),CyTOF-ready,Knockout Validated.

target :

Mer

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

125518

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Mer, Met1-Ala499, Accession # AAB60430

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human Mer in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) Axl, rhDtk, or recombinant mouse Mer is observed.

gene symbol :

MERTK

Antibody validation :

Knockout/Knockdown

top caption :

Detection of Mer antibody in HepG2 Human Cell Line antibody by Flow Cytometry.

accessionNumbers :

AAB60430

applications :

Immunoprecipitation,Western Blot,Flow Cytometry,Immunohistochemistry-Paraffin,ELISA Capture (Matched Antibody Pair),CyTOF-ready,Knockout Validated

USD :

539 USD

alt names :

c-Eyk, C-mer, c-mer proto-oncogene tyrosine kinase, EC 2.7.10, EC 2.7.10.1, MER, MER receptor tyrosine kinase, MerTK, MGC133349, Receptor tyrosine kinase MerTK, RP38Proto-oncogene c-Mer, STK kinase, tyrosine-protein kinase Mer

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage